Next - generation sequencing (NGS), also known as high - throughput sequencing, is changing the field
of microbial genomics research.
The genomes described this month reflect the overall historical bias
of microbial genomics towards pathogenic bacteria.
Not exact matches
Wth technology addressing skin
microbial therapeutics, fertility science, chronic disease alleviation, post traumatic stress disorder treatments, and services for the biopharmaceutical and clinical research industries; the startups selected by Illumina will have access to the company's
genomics and sequencing expertise, business coaching, lab and office space and an infusion
of capital.
«I think it's important [for journals] to be discussing this, but I think it's unrealistic to think that journals can and should play the role
of the sole enforcer,» says Claire Fraser, director
of The Institute for
Genomic Research in Rockville, Maryland, which posts a range
of microbial gene sequences online.
In the current study, for example, they utilized
genomic information from hundreds
of microbial species commonly found in humans to create computer models
of nutrient and energy metabolism.
In a perspective piece published November 6 in the journal Science, Eddy Rubin, Director
of the U.S. Department
of Energy Joint Genome Institute (DOE JGI), a DOE Office
of Science User Facility, along with
Microbial Program Head Tanja Woyke, discusses why the time is right to apply
genomic technologies to discover new life on Earth.
Stories about
microbial hitchhikers, the largest dam - removal project in North America, and issues raised by the new era
of personal
genomics are among the winners
of the 2012 AAAS Kavli Science Journalism Awards.
This collection
of marine
microbial genomic, the first in the world on a global scale, will provide new clues about a reservoir
of biodiversity yet to explore, considering that it could imply the discovery
of tens
of millions
of new genes in the coming years.
Sapp explores how molecular methods have changed our understanding
of microbial genetics and
genomics and the large - scale relationships among microbes.
«The
microbial world is one
of the last frontiers
of exploration on our planet, and we're using microscopes together with
genomics to learn as much as possible about this invisible life.»
Clement Furlong, a researcher in medical and
genomic sciences at the University
of Washington notes that the «huge advantage»
of these heavy - chain - only antibodies «is that you can make them by fermentation in
microbial systems and make a lot
of antibodies inexpensively.»
A team
of scientists announced that they have sequenced the genome
of the common soil bacterium Streptomyces coelicolor — the largest
microbial genome to date — unearthing both promising and surprising
genomic features.
For example, the large - scale sequencing program has already started to sequence the genomes
of 100 microorganisms found in the human gut, and will build on this by using
genomic sequencing to characterize the complex
microbial communities found at many sites in and on the human body.
Use
of genomics to design a diagnostic assay to discriminate between Streptococcus pneumoniae and Streptococcus pseudopneumoniae — Matthew A. Croxen —
Microbial Genomics
Additional uses include precise diagnosis
of microbial infection, describing transmission patterns, understanding the
genomics of emerging drug resistance and identifying targets for new therapeutics and vaccines.
Therefore, we propose to perform metagenomics and transcriptomics analysis on vaginal samples from patients with high - and low - risk HPV phenotypes to investigate the
microbial population dynamics and
genomic diversity
of the vagina during various stages
of HPV infection compared to uninfected individuals.
«Over the last several years, single - cell
genomics has become a popular tool to complement metagenomics,» said study senior author Tanja Woyke, head
of the DOE JGI
Microbial Program.
The focus
of the Microbiome Ideas Challenge is the development
of new tools and methods that will help transition the field
of microbiome research from correlative studies — i.e.,
genomics - driven
microbial censusing efforts — to causal understanding
of microbial function.
The recent realization
of the vastness
of microbial diversity and the
genomics revolution have propelled the
microbial sciences into an exciting new era
of investigation.
«Single cell
genomics can be applied to understand the heterogeneity
of tumors, to explain how genetically identical cells may show distinct behavior, and to explore the vast, uncharacterized
microbial landscape.
The project will be the first to statistically analyze anthropological and environmental data alongside
genomics data
of the
microbial communities
of human milk and the corresponding bacteria present in the gastrointestinal tracts
of infants.
Single cell
genomics is an emerging technology enabling the exploration
of genomes
of individual
microbial cells without the need for prior cultivation.
Dr. Venter is founder and CEO
of JCVI, leaders in human,
microbial, and synthetic
genomics.
Disa will work on the
genomic exploration
of «
microbial dark matter», focusing on new archaeal lineages and viruses, using both lab - and bioionformatics - based approaches.
«More than 200
microbial species live in the digestive systems
of cows and other ruminants,» says Karen Nelson, a
microbial genomics researcher at TIGR.
Over 64
of these papers reported studies on the
genomics of microbial pathogens since 2008.
The Faculty
of Life Sciences at the University
of Vienna has gathered an exceptional number
of renowned experts over the past years with complementary research areas in
microbial ecology, functional
genomics and aquatic and terrestrial ecosystem research.
William Nierman, PhD, has studied
microbial genomics since joining the faculty
of The Institute for
Genomic Research (TIGR) in 1998.
SciLifeLab and the host universities want to support young researchers and further strengthen the research environment at SciLifeLab and are therefore now advertising eight career positions for research leaders, two at each
of the universities, in the fields
of microbial bioenergy production, applied physics, biomedical sciences, ecological
genomics, RNA biology, molecular medicine and molecular biosciences.
The Swedish Biodiversity Program aims to target biodiversity
of bacteria, viruses, archaea and eukaryotes and combinations thereof to promote large research projects aiming to uncover and understand
genomic variability in nature by use
of massively parallel sequencing and
microbial single cell analysis.
The topics will be single cell
genomics and transcriptomics
of unknown
microbial species.
JCVI continues to lead the world in
genomic science with new programs to improve understanding in the areas
of genomic medicine, infectious disease,
microbial and environmental
genomics, synthetic biology, and informatics.
Genetic and
genomic analysis
of nucleic acids from environmental samples has helped transform our perception
of the subsurface as a major reservoir
of microbial novelty.
He is Founder, Chairman and President
of the J. Craig Venter Institute (JCVI), a not - for - profit, research organization with more than 400 scientist and staff dedicated to human,
microbial, plant, synthetic and environmental
genomic research, as well as the exploration
of social and ethical issues in
genomics.
Paul's research expertise includes: cultivation
of marine bacteria,
microbial distribution and interactions with marine plants and invertebrates, sequence - based approaches to the discovery
of natural products from marine microbes, comparative
genomics,
microbial chemical ecology, molecular evolution and natural product biosynthesis.