«This study suggests that laboratory studies
of microbial metabolite processing can help understand the role of these microbes in carbon cycling in the environment.
Not exact matches
Ultimately, this may enable the prediction
of nutrient cycling in terrestrial
microbial ecosystems, and perhaps even manipulation by adding specific
metabolites.
In the end, the identification
of microbial species or
metabolites that are altered in Parkinson's disease may serve as disease biomarkers or even drug targets, and interventions that correct
microbial imbalances may provide safe and effective treatments to slow or halt the progression
of often debilitating motor symptoms.
By contrast, mice raised in the germ - free cages showed worse motor symptoms when they either were treated with
microbial metabolites called short - chain fatty acids or received fecal transplants
of gut microbes from patients with Parkinson's disease.
«What we're really trying to define is what is the connection between the diversity
of metabolites and
microbial diversity?
Microbial metabolites, short - chain fatty acids, restrain tissue bacterial load, chronic inflammation, and associated cancer in the colon
of mice.Kim M. European Journal
of Immunology
In a study recently published in Frontiers in Microbiology, PNNL scientists Young - Mo Kim, Jim Fredrickson, and Tom Metz demonstrated the effect that sunlight or the absence thereof over a 24 - hour period - the diel cycle - has on the production
of chemicals used as
metabolites in the
microbial mats
of Mushroom Springs in Yellowstone National Park.
This indicates to Brodie that as they establish the
microbial community within the rhizosphere, plants could be exuding
metabolites like phenolic acids to help them control the types
of microbes thriving around their roots.
The focus
of this position will be to examine mechanistic links between gut
microbial metabolites and liver disease progression using a highly translational approach.
2) Understanding the roles
of gut
microbial metabolites in animal models
of NAFLD and ALD progression.
3) Identifying targets for the development
of new pharmacologic therapies including drugging
microbial enzymes that generate disease - causing
metabolites.
Chapter 4, by Demain and Sergio Sanchez, deals with
microbial synthesis
of primary
metabolites.
--
Microbial metabolism
of dietary components to bioactive
metabolites: opportunities for new therapeutic interventions, April 2016.