Like our lab run a ton
of microbiome data.
Comparison
of microbiome data from the alcohol model, BDL, CCl4, and an obesity model noted that there was no common liver disease microbiome, suggesting that the intestinal microbiome differs by etiology of liver disease.
Not exact matches
Even in IBD patients, who have a very messed up
microbiome (a finding
of the American Gut
data), the benefits
of antioxidant therapy is well documented (see below studies).
The contribution
of the mode
of delivery to the infant
microbiome has been evaluated.13, 15,24 However, no study has examined the effects
of delivery mode and breastfeeding following adjustment for the other, and, to our knowledge, there are few
data on the effects
of combination feeding (feeding breast milk and formula together).
If hormone surges are important for the
microbiome transmission during labor and in breast milk, as the unplanned Cesarean
data suggest, how could the natural hormone surges
of labor be mimicked for planned Cesarean?
There are so many variables to the birth process that many
of these questions could only be answered with extremely detailed
data of tens
of thousands
of mother - infant -
microbiome triads over time.
This is a highly limiting factor for research, because it complicates the annotation
of data obtained by molecular techniques, and because it has been shown that gut
microbiomes are to some extent specific to their host, and researchers have been using strains
of other origin in mouse models.
When the team looked for it in
data from the Human
Microbiome Project, a large - scale project to sequence the DNA
of all the microbes that live in and on our bodies, they found that it was present in 73 per cent
of all 466 faecal samples.
The researchers did a small study
of existing genetic
data from the human skin
microbiome and estimate that 20 percent
of the human population have S. epidermidis strains that make 6 - HAP on their skin, Gallo says.
But «one day,» Jackson says, «a genetic profile
of our
microbiome will be taken by doctors, with treatments prescribed from instant molecular
data.»
France Córdova, director
of the National Science Foundation, also addressed the forum, saying NSF's agenda over the next decade will come from «10 big ideas» including understanding the changing Artic, leveraging artificial intelligence, harnessing big
data, developing quantum enabled technology, studying the
microbiome and advancing research about gravitational waves.
«The
microbiome of a cadaver is an unknown
data set in biology,» she says.
To investigate, researchers from the Channing Division
of Network Medicine at Brigham and Women's Hospital, led by Amir Bashan, PhD, and Yang - Yu Liu, PhD, analyzed
data from large metagenomic datasets (e.g. the Human
Microbiome Project and Student
Microbiome Project) to look at the dynamics
of the gut, mouth and skin
microbiomes of healthy subjects.
When the researchers expanded their search to include all the
data from the Human
Microbiome Project, a large - scale project to sequence the DNA
of all the microbes that live in and on our bodies, they found that the same virus was present in 73 per cent
of all 466 human faecal samples.
«The
microbiome is incredibly complex and has been the subject
of intense study in the last few years, due to the development
of deep sequencing and most importantly, due to the ability to analyze this complex
data,» said Patterson.
ET: «What this
data analysis pipeline, moreover, creates is motivation to look for similar forms
of gene loss in other types
of symbioses, such as that between humans and their gut
microbiomes.
Analyzing this wealth
of data required overcoming the formidable bioinformatics challenge
of sorting and identifying millions
of genetic sequences like puzzle pieces in order to reconstruct the complex biology
of the ancient oral
microbiome.
«We are about six months away from having the
data to completely describe the bacterial
microbiome of grapevine tumors,» said Michael Savka, professor
of biological sciences in the Thomas H. Gosnell School
of Life Sciences at RIT, and organizer and contributor
of the international study.
At the beginning
of the semester, students were given the option to use their own personal information gained through a
microbiome kit, or they could use demo
data.
Michael Blaut, a microbiologist at the German Institute
of Human Nutrition in Potsdam, Germany, says the mouse
data are «believable and remarkable,» but says he has a hard time imagining a mechanism that would account for three compounds as chemically different as aspartame, saccharin, and sucralose leading to the same changes in the gut
microbiome.
«Mining sequence
data in DOE JGI's Integrated Microbial Genomes &
Microbiomes system, which houses thousands
of metagenomes, allowed us to find evolutionary relatives
of our Klosneuvirus,» Schulz said.
Segal and Elinav believe that over time, with the further addition
of data to their study and those
of others, these recent findings may be further validated, and the connection between our
microbiome, our genetics and our health will become clearer.
We also assess performance in real 16S
data, where we reanalyze previous genetic association
data to show that relative to other widely used quantification methods Karp reveals a larger number
of microbiome quantitative trait association signals.
Actinobacterial community structure in the Polar Frontal waters
of the Southern Ocean
of the Antarctica using Geographic Information System (GIS): A novel approach to study Ocean
Microbiome — P. Sivasankar —
Data in Brief
«The
data presented at AACR provide important new models and mechanistic insights that inform our planned development efforts to evaluate the ability
of microbiome therapy to augment immune checkpoint inhibitors,» said David Cook, Ph.D., Chief Scientific Officer and Executive Vice President
of Research at Seres.
«It was the first analysis
of the gut
microbiome among a foraging population, and the
data indicated that some
of our old longstanding ideas about the differences between «good» and «bad» gut bacteria needed to be re-evaluated,» she said.
Seres Therapeutics (MCRB) Presents New Preclinical
Data Supporting the Development
of Microbiome Therapeutics for Immuno - Oncology at AACR
The complete genome sequence
data from the collected viruses will not only expand our knowledge
of the virulence factors, but provide detailed information on evolution and transmission
of RSV strains, host - pathogen interactions, and pathogen -
microbiome relationships that occur during viral infection.
The
data presented provide new insights on the potential mechanism by which Seres»
microbiome therapies could improve the outcomes
of cancer patients treated with immune checkpoint inhibitors.
Seres Therapeutics, Inc. (NASDAQ: MCRB) today announced that new preclinical
data supporting the development
of microbiome therapeutics for immuno - oncology (leveraging gut microbiota to impact tumor immunotherapy) 1 will be presented today by Sceneay et al in the late breaking poster session at the 2018 American Association for Cancer Research Annual Meeting (AACR) in Chicago.
Along with the genomic
data gleaned from the sequencing
of complete human genomes, HLI will also be generating
microbiome data for many
of these individuals through its Biome Healthcare division, under the leadership
of Karen Nelson, Ph.D..
* The Skin
Microbiome of the Neotropical Frog Craugastor fitzingeri: Inferring Potential Bacterial - Host - Pathogen Interactions From Metagenomic
Data — Eria A. Rebollar — Frontiers in Microbiology
«Other key public
microbiome data management systems such as MG - RAST, IMG and GOLD have also adapted the MIxS standards,» said Nikos Kyrpides, head
of the DOE JGI Prokaryote Super Program and GSC Board member.
To address IBD, Jansson's team has collaborated with bioinformaticians to integrate overwhelming amounts
of new genetic
data, and has published studies comparing healthy
microbiomes to those in IBD patients - all with the aim
of future diagnostics and potential new therapies, she said.
«By leveraging
data and insights across disciplines, we hope to accelerate development
of new preventive therapies for human diseases and influence policies that promote a healthy
microbiome.»
They also plan to evaluate whether colorectal tumor
microbiome composition can be assayed from stool samples, and if this
data can also be used to predict the type
of mutations present in the tumor cells.
Her main achievement, however, was the assessment
of important components
of the human
microbiome and to unreval major functional traits, which induce derivation
of data sets.
One person's
microbiome creates ten computers» worth
of information, meaning that
data analysis, not collection, has become the bottleneck in research.
Shows you how your bacterial strains and levels compare to the National Institutes
of Health's Human
Microbiome Project
data on gut bacterial strains
Even in IBD patients, who have a very messed up
microbiome (a finding
of the American Gut
data), the benefits
of antioxidant therapy is well documented (see below studies).