Researchers are finding this lack
of microbiome diversity plays a role in many chronic health and brain disorders, including depression and autoimmune diseases such as Hashimoto's hypothyroidism.
Not exact matches
And what we found is that, in patients who responded to the treatment, they actually had a much higher
diversity of bacteria in their gut
microbiomes compared to non-responders.»
A lack
of gut
microbiome diversity has been linked to type 2 diabetes, and increasing this
diversity can help keep diseases like diabetes and heart disease away.
It also provides low - FODMAP prebiotic sources in order to support the
diversity of the gut
microbiome.
Participant Characteristics and Variability and
Diversity of the Early Neonatal
Microbiome
A new Canadian study finds that the
microbiome of infants born via unplanned Cesarean had increased bacterial richness and
diversity, more similar to that
of vaginally born infants than planned Cesarean [10].
They analyzed stool samples collected from children in the urban slums
of Dhaka, Bangladesh, and determined that children with more severe infections had less
diversity in their gut
microbiome.
The investigators examined 181 bacterial genomes taken from the female urinary
microbiome, which Dr. Putonti said were representative
of that
microbiome's phylogenetic
diversity.
«This is just the first in what will likely be numerous studies into the phage
diversity of the urinary
microbiome,» said Dr. Putonti.
When on the low - fiber diet, animals showed a decrease in the
diversity of their
microbiome, with 60 percent
of the bacteria species plummeting in numbers compared with their high - fiber friends.
Jackson's work on microbial
diversity caught the attention
of Seed, who was already interested in the
microbiome in the guts
of preterm infants but who did not have a background in ecology.
The Duke study is just one
of many projects begun in the past five years that use genetic sequencing to explore how the
diversity of the
microbiome impacts our health.
As Venkateswaran and colleagues explain online today in
Microbiome, they relied on state -
of - the - art «deep - sequencing» machines, which are better able to assess
diversity and abundance
of organisms than traditional techniques.
Interestingly, the Americans lacked some
of the strains
of bacteria found in Malawians — and in gorillas and chimps — which fits with the general reduction in gut
microbiome diversity that has been observed in people in industrialized societies, perhaps because
of changes in diet and the use
of antibiotics.
Interestingly, these semi-captive animals»
microbiomes fell right in between those
of the wild and captive doucs, further supporting they hypothesis that lower plant consumption causes loss
of microbial
diversity.
In samples from HIV - infected untreated men, semen
microbiome diversity was markedly reduced, and the relative abundance
of the more common bacterial groups differed.
«Greater
diversity of bacteria in the gut
microbiome is associated with both a higher response rate to treatment and longer progression - free survival,» said study leader Jennifer Wargo, M.D., associate professor
of Surgical Oncology at MD Anderson.
The suggested focus should be in building the resilience
of society and maintaining
diversity in the «global
microbiome» — only a fraction
of which causes human or animal disease.
«Ochman and colleagues show that human evolution was accompanied by both a rapid divergence
of the
microbiome from the
microbiome of apes, and a drastic loss
of diversity of the microbial community,» says Thomas Bosch
of the Christian Albrechts University in Kiel, Germany.
«Our findings point to two potential impacts from additional research — analyzing the
diversity and composition
of the
microbiome to predict response to immunotherapy and modulating the gut
microbiome to enhance treatment,» said Wargo, senior researcher on the project and co-leader
of the Melanoma Moon Shot ™, part
of MD Anderson's Moon Shots Program ™ to reduce cancer deaths by accelerating development
of therapies from scientific discoveries.
In the handful that developed T1D during this period, the team observed a 25 % drop in community
diversity (in other words, in the number
of distinct species present in the
microbiome) one year prior to the onset
of the disease.
As Mani Subramanian, Summers's adviser, points out, 90 %
of the cells in our body are bacterial, and research into the human
microbiome, our total complement
of bacteria, has revealed that we are veritable rainforests when it comes to bacterial
diversity.
«Reduction in dietary
diversity impacts richness
of human gut microbiota: Dietary
diversity necessary for a healthy gastrointestinal
microbiome.»
Despite the importance
of our skin microbiota, we still know very little about what shapes the distribution and
diversity of the skin
microbiome.
For instance, one priority could be to increase the number and
diversity of people sampled in studies
of the human
microbiome.
Pollard, senior investigator at the Gladstone Institutes and professor
of epidemiology and biostatistics at the University
of California, San Francisco, delivered a presentation titled «Estimating Taxonomic and Functional
Diversity in Shotgun Metagenomes» during an invited session focused on statistics, the
microbiome and human health.
This has led to an explosion
of knowledge about
microbiomes, as scientists use these tools to catalog the stunning
diversity of species that inhabit the planet and study their genes.
«We determined that the uterine
microbiome is not simply a subset
of the vaginal
microbiome and that microbial
diversity increased with stage III endometriosis,» said ORNL's Melissa Cregger, lead author
of a pilot study published in Reproductive Immunology.
Through the Earth
Microbiome Project, he seeks to characterize the microbial
diversity of our planet.
Impaired
diversity of the lung
microbiome predicts progression
of idiopathic pulmonary fibrosis — Youhei Takahashi, Respiratory Research
Professor Segal's research has two major directions 1) Gene regulation — using quantitative and computational models to understand how DNA sequence variation among human individuals generates phenotypic
diversity 2)
Microbiome and Nutrition — understanding how the microbial composition
of individuals affect their physiology and health.
Low dose brain estrogen prevents menopausal syndrome while maintaining the
diversity of the gut
microbiomes in estrogen - deficient rats — Sunmin Park — American Journal
of Physiology - Endocrinology and Metabolism
Conversely, the species
diversity of the vaginal
microbiome of HPV - positive women tends to be higher with significantly less Lactobacillus spp..
The results indicate that the enormous bacterial
diversity residing in natural soils may account for the stability
of the plant -
microbiome relationship.
The study, published July 21, 2016, in Scientific Reports, also showed significant changes in the gut
microbiome after antibiotic treatment, suggesting the composition and
diversity of bacteria in the gut play an important role in regulating immune system activity that impacts progression
of Alzheimer's disease.
Human gut
microbiome ** Competitively Selected Donor Fecal Microbiota Transplantation: Butyrate Concentration and
Diversity as Measures
of Donor Quality.
Plant, root, and soil
microbiome Photoautotrophic organisms control microbial abundance,
diversity, and physiology in different types
of biological soil crusts.
For example, lower
diversity of the gut
microbiome has been associated with obesity and inflammatory bowel disease (IBD), and higher
diversity in the vagina with bacterial vaginosis.
There is high
diversity of studies, with a high abundance
of gut
microbiome studies, a few publications on fecal transplant, and some very interesting early life / pregnancy / mother - infant science.
Our understanding
of the
diversity and roles
of these
microbiomes is limited, a fact that led the White House Office
of Science and Technology Policy to launch the National
Microbiome Initiative last year.
Ken is currently involved with several research projects, including the US - based eXtreme
Microbiome Project (XMP), as well as evaluating emerging technologies that can be used to profile the
diversity of microbial communities.
In the proposed partnership between Addis Ababa University (AAU) and J. Craig Venter Institute (JCVI), the objective is to build genomics capacity at AAU and to apply newly developed skills towards understanding the relationships
of active TB disease with Mtb strain type
diversity and host components such as the human respiratory
microbiome and protein - based analysis
of immune responses in the respiratory tract.
As shown in FIG. 1A, a first method 100 for diagnosing and treating an autoimmune condition comprises: receiving an aggregate set
of samples from a population
of subjects S110; characterizing a
microbiome composition and / or functional features for each
of the aggregate set
of samples associated with the population
of subjects, thereby generating at least one
of a
microbiome composition dataset and a
microbiome functional
diversity dataset for the population
of subjects S120; receiving a supplementary dataset, associated with at least a subset
of the population
of subjects, wherein the supplementary dataset is informative
of characteristics associated with the autoimmune condition S130; and transforming the supplementary dataset and features extracted from at least one
of the
microbiome composition dataset and the
microbiome functional
diversity dataset into a characterization model
of the autoimmune condition S140.
A healthy skin
microbiome should contain a
diversity of bacteria including ammonia - oxidizing bacteria, which convert ammonia in sweat to beneficial nitrates.
Macmillan, 2014; Holler, E., et al. «Metagenomic analysis
of the stool
microbiome in patients receiving allogeneic stem cell transplantation: Loss
of diversity is associated with use
of systemic antibiotics and more pronounced in gastrointestinal graft - versus - host disease.»
Here is just one such study, which although small in sample size was able to demonstrate that a low residue diet (LRD, aka low fiber diet) resulted in a decrease in
microbiome diversity among patients with Crohn's disease, which is indicative
of gut dysbiosis..
Is it safe to say, as a general take away, that optimizing the
diversity of your
microbiome is positively correlated with optimizing your immunity and overall health?
As shown in FIG. 1A, a first method 100 for diagnosing and treating an autoimmune condition comprises: receiving an aggregate set
of samples from a population
of subjects Silo; characterizing a
microbiome composition and / or functional features for each
of the aggregate set
of samples associated with the population
of subjects, thereby generating at least one
of a
microbiome composition dataset and a
microbiome functional
diversity dataset for the population
of subjects S120; receiving a supplementary dataset, associated with at least a subset
of the population
of subjects, wherein the supplementary dataset is informative
of characteristics associated with the autoimmune condition S130; and transforming the supplementary dataset and features extracted from at least one
of the
microbiome composition dataset and the
microbiome functional
diversity dataset into a characterization model
of the autoimmune condition S140.
So, drinking the alcohol and changing the
diversity of their
microbiome in a way that was not beneficial and caused the mice to have a worse outcome when they did become sick.
Good fibers called arbinogalactans from carrots, onions, radishes & jicama help to feed the gut
microbiome and improve the
diversity of beneficial species.