«The combination
of microbubbles chipping away outside and inside the clot is like poking holes in the clot and turning it into Swiss cheese allowing blood to reach the heart muscle,» says Porter.
«Using the theory
of microbubbles and how their surface vibrates under ultrasound, we were able to come up with our solution that addresses these three challenges.»
Not exact matches
Serving as the acoustic indicator
of drug delivery dosage, the
microbubble emission signal y (t) is used to find the expected controller output u (f) which is fed back to help control ultrasound transducer transmission.
The shipping industry is already experimenting with
microbubbles, applied to the underside
of ship hulls, to reduce friction and improve fuel efficiency.
If this type
of therapy proves safe in humans, a syringe full
of oxygen
microbubbles could help avert brain damage and death for the victims
of cardiac arrest, asthma attacks, strokes, and injuries to the lungs, airway, or face.
By placing sensors on the outside
of the brain that act like secondary microphones, the research team could listen to ultrasound echoes bouncing off the
microbubbles to determine how stable the bubbles were.
Just 1 / 100th the size
of a human hair,
microbubbles sneak into very small canals within the complex clot and their oscillation from ultrasound causes a breakup
of the clot from the inside as well.
The treatment consists
of injected
microbubbles which are detected by diagnostic ultrasound when they reach the heart.
Recanalization rates improved from 36 % for half dose tPA alone to 83 % with the addition
of ultrasound /
microbubbles.
The ultrasound penetrates through the chest tissue to hit and activate the intravenously infused
microbubbles at the site
of the blockage.
Over all, the combination
of ultrasound /
microbubbles and a low dose
of tPA resulted in the most significant preservation
of healthy heart tissue and the smallest infarct size.
An ultrasound - stimulated
microbubble burrows through a fibrin clot (green) allowing penetration
of the surrounding fluid into the clot (yellow).
By binding to the protein SFRP2, the
microbubble contrast agent greatly improves the resolution and tumor - detecting ability
of scans produced by ultrasound.
The careful choice
of the pig model as well as use
of readily available
microbubbles and ultrasound was instrumental in studies moving to clinical trials.
Proposals include floating grains or
microbubbles that would reduce the absorption
of the Sun's rays.
Transient permeabilization
of cell membranes by ultrasound - exposed
microbubbles is related to formation
of hydrogen peroxide.
Low - intensity ultrasound - exposed
microbubbles provoke local hyperpolarization
of the cell membrane via activation
of BKCa channels.
Injecting breast cancer with oxygen - filled
microbubbles makes tumors three - times more sensitive to radiation therapy and improves survival in animal models
of the disease.
Increased local delivery
of antagomir therapeutics to the rodent myocardium using ultrasound and
microbubbles.
Akadeum's groundbreaking
microbubble technology — which allows for fast, easy removal
of target cells from biological...
I had been interviewed for a BBC documentary on my work to use
microbubbles to improve cancer treatment, and that's when I got a call from my collaborator Ray Averre
of Avrox Technologies to ask if it would be possible to make a sports drink using tiny bubbles
of oxygen.
Danielle Benoit (right), associate professor
of biomedical engineering, and Lisa A. DeLouise, associate professor
of dermatology, use «
microbubbles» to regenerate salivary gland cells.
Lapotko D, Lukianova E, Оraevsky A. Selective laser nano - thermolysis
of human leukemia cells with
microbubbles generated around clusters
of gold nanoparticles.
There are two ultrasound techniques that can help identify vulnerable plaques, but both depend on the use
of contrast agents called «
microbubbles.»
When
microbubbles are injected into an artery, they follow the flow
of the blood.
One hose at the bottom
of the tub pulls water into the machine, where it is charged and bubbled, and another hose delivers
microbubbles to the pet.
However, more recent research modelling the impacts
of using
microbubbles to address global warming found that the technique would not affect ocean primary productivity, a measure
of the activity
of primary producers.
In theory, this would involve using a fleet
of sea vessels to churn up millions
of tiny
microbubbles on the ocean surface.
On top
of this, creating enough
microbubbles at the ocean's surface to have an overall cooling effect on the planet could require large amounts
of energy, according to research co-authored by Evans.
(Brennen, 1995) In gas - free water, the pressure due to interfacial curvature rapidly drives micron - sized bubbles into solution, but in air - saturated water (22 mg l - 1 at STP), but in the presence
of film - forming impurities, either present naturally or intentionally added,
microbubbles may last for tens to hundreds
of seconds.
31), including pressure - driven continuous gas - phase flow through dry or water - saturated fractures and density - driven buoyancy
of gas
microbubbles in aquifers and water - filled fractures (31).