The discovery doesn't prove the Zika virus is the cause of thousands of cases
of microcephaly in Brazilian babies since the spring.
The Pan American Health Organization says cases
of microcephaly in Brazil increased 20-fold last year.
The CDC said the precaution is in place «until we know more» about the dangers of sexual transmission of the mosquito - borne virus, which is linked to thousands of cases
of microcephaly in newborns in Brazil.
Since the Zika epidemic began last spring, it's believed there have been more than 5,600 suspected or confirmed cases
of microcephaly in Brazil, the World Health Organization reported Friday.
A recent increase in the prevalence
of microcephaly in newborn infants and vision - threatening findings in these infants is likely associated with the rapid spread of ZIKV.
Based on data from population - based birth defects surveillance programs for 2009 - 2013, the median prevalence
of microcephaly in the United States was approximately 7 per 10000 live births.29 There are no published estimates of the prevalence of the birth defects potentially related to Zika virus infection during pregnancy combined.
«Studies of fetuses and babies with the telltale small brains and heads
of microcephaly in Zika - affected areas have found abnormalities in the cortex, and Zika virus has been found in the fetal tissue,» says Guo - li Ming, M.D., Ph.D., a professor of neurology, neuroscience, and psychiatry and behavioral science at Johns Hopkins» Institute for Cell Engineering.
Since October, Brazil has reported more than 4,000 suspected cases
of microcephaly in areas with Zika circulation.
Although Zika causes no harm in most people it infects, its possible role in clusters
of microcephaly in babies and Guillain - Barré syndrome in adults led the World Health Organization on 1 February to declare that it is a «public health emergency of international concern.»
The WHO in February declared the Zika virus an international public health emergency due to its association in Brazil with suspected cases
of microcephaly in babies.
Brazil said on Friday the number of confirmed and suspected cases
of microcephaly in Brazil associated with the Zika virus has risen to 5,131 from 4,976 a week earlier.
It has been linked to more than 1,600 cases
of microcephaly in Brazil.
Not exact matches
One
of the reasons it's been so troubling is that it's a cause
of a serious birth defect called
microcephaly,
in which the head
of babies whose mothers have been infected with Zika during pregnancy are abnormally small.
This appears to be the first US case
of a baby born with
microcephaly, a condition
in which the brain is abnormally small, after having a Zika infection.
In April, the CDC confirmed that Zika is a cause of microcephaly, a condition in which the head is born abnormally smal
In April, the CDC confirmed that Zika is a cause
of microcephaly, a condition
in which the head is born abnormally smal
in which the head is born abnormally small.
One reason Zika is troubling is that it is a cause
of birth defects, including
microcephaly — a condition where the baby's head is abnormally small —
in babies whose mothers have had Zika.
One reason Zika is troubling is because it is a cause
of birth defects, including
microcephaly — a condition where the baby's head is abnormally small —
in babies whose mothers have had Zika.
The agency said there have been recent variations
in the number
of cases reported
in the region and, while the level
of risk is unknown, Zika virus infection during pregnancy causes severe birth defects, including
microcephaly and other severe brain abnormalities.
After taking samples and conducting brain scans, the researchers found that 41 percent
of mothers
of babies with
microcephaly tested positive for Zika infection
in blood or cerebrospinal fluid samples, compared with none
of those whose babies did not have
microcephaly.
The outbreak
of Zika, a mosquito - borne disease, was detected last year
in Brazil, where it has been linked to more than 1,700 cases
of microcephaly, a birth defect marked by small head size that can lead to severe developmental problems.
The study, published
in The Lancet Infectious Diseases journal, was requested by the Brazilian health ministry to investigate the causes
of the
microcephaly epidemic that the World Health Organization (WHO) declared an international public health emergency earlier this year.
The number
of babies born with
microcephaly in northeast Brazil, the country hardest hit by the Zika outbreak, has increased about 40-fold from baseline levels
in the last six months, according to reports from Brazil's Ministry
of Health.
The connection between Zika and
microcephaly first came to light last fall
in Brazil, which has now confirmed more than 1,800 cases
of microcephaly that it considers to be related to Zika infection
in the mothers.
The WHO says there is strong scientific consensus that Zika is a cause
of the birth defect
microcephaly, or small heads
in babies, as well as Guillain - Barre syndrome, a neurological disorder.
Given the latest outbreak
of the Zika virus this year, we know that
in some cases contraceptives are imperative to reduce incidences
of birth defects, like
microcephaly.
Mothers and families
of infants born with congenital anomalies (e.g.
microcephaly) should be supported to breastfeed their infants
in line with WHO recommendations.
Menabde said currently 34 countries had reported the Zika virus outbreak, mostly
in the Americas and Caribbean, and seven reported an increase
in cases
of microcephaly.
«The rise
of microcephaly cases and other neurological disorders
in the affected regions is extremely worrying,» he said.
But health officials suspect it may be behind a surge
in cases
of microcephaly, a condition which causes babies to develop abnormally small brains and skulls — leading to permanent disability or death.
Although one
of the most serious consequences
of the Zika virus (ZIKV)
in infants is
microcephaly, there is a broad collection
of anomalies now known as congenital Zika syndrome (CZS).
A 2006 study
of 77 pregnant women infected with West Nile virus reported that two had infants with
microcephaly, the birth defect lately associated with Zika that results
in unusually small and damaged brains.
As we report
in a collection
of stories, much remains unclear, including the relationship between Zika infection and
microcephaly and how best to combat the mosquitoes that spread the disease.
Using human fetal «mini-brains» grown
in 3 - D cultures, scientists determined that a specific protein produced by the Zika virus changes the properties
of neural stem cells
in the developing brain
of an infected fetus, potentially causing
microcephaly in newborns (Ki - Jun Yoon, abstract 103.06, see attached summary).
Among the 42 Zika - infected women
in the study, 12 were carrying fetuses with severe abnormalities, including absence or withering
of brain structures, tissue death, restricted growth and,
in one case,
microcephaly.
«We've been seeing growing evidence
of the association between Zika and congenital central nervous system malformations, not just
microcephaly, since the first cases were picked up,» says Wim Van Bortel, senior expert on vector - borne diseases at the European Centre for Disease Prevention and Control
in Solna, Sweden.
Furthermore, the defects observed are specific to an infection by ZIKV, as other neurotropical viruses
of the flavivirus family (West Nile virus, yellow fever,...) did not cause
microcephaly,
in contrast to Zika virus.
A far higher number
of babies
in Colombia have developed
microcephaly related to Zika virus infections than previously reported.
In their most impressive experiment, the scientists derived organoids from the skin cells
of a person affected by
microcephaly.
Other infections also can cause
microcephaly;
in fact, out
of 121 infants tested for other pathogens, 26 had evidence
of infection with either toxoplasmosis, herpes simplex, cytomegalovirus, and syphilis.
Two
of them also prove for the first time
in an animal model that Zika virus can cause
microcephaly in fetuses.
In contrast, the latest World Health Organization (WHO) «situation report,» with data current to 7 December, said that Colombia had only reported 60 cases
of microcephaly or central nervous system malformations potentially linked to Zika.
Now, it is being deployed to monitor the Zika as it spreads beyond Brazil, where reports last August
of fetal deaths and newborns with brain disorders including
microcephaly, a devastating condition that results
in abnormally small brains and heads, began to trickle
in.
In Brazil, thousands
of babies have been born with
microcephaly after their mothers were infected with Zika virus.
One
in 150 babies
in the U.S. is born with a congenital CMV infection, and
of those, one
in five suffers from complications, according to the CDC, which can include including hearing loss, vision loss, cerebral palsy, cognitive impairments and
microcephaly.
Some researchers wondered, though, about the extent
of Zika's role
in microcephaly in Colombia.
Earlier this year, the country's tally
of microcephaly cases seemed smaller than expected, given the reported rise
in Zika infections.
That study showed a change
in a pre-membrane protein could cause
microcephaly; the Nebraska study showed how glycosylation
of the envelope protein may contribute to the virus efficiently gaining entry into the brain.
There has been a 20-fold increase
in the number
of babies born with this condition, known as
microcephaly, since Zika first appeared
in Brazil
in May 2015.
In Brazil, the country hit hardest by the epidemic so far, there have been 6,906 suspected cases
of microcephaly as
of April 2, 2016.
An association between Zika infections during pregnancy and the birth
of babies with
microcephaly (a birth defect
in which an infant's brain does not develop properly resulting
in a smaller than normal head) was first suggested by Brazilian physicians
in August 2015, and
in November
microcephaly cases potentially associated with Zika started to be recorded; three months later WHO made its announcement.