The study also casts doubt on researchers» plans to employ special killer bacteria to combat infections, says microbiologist Herbert Schweizer at Colorado State University in Fort Collins, such as the use
of microcin - secreting E. coli to treat Salmonella infections in chickens.
Not exact matches
She added that
microcins are essential for the therapeutic activity
of E. coli Nissle, and her next step is to purify
microcins and test whether they can be given as targeted antibiotics.
In their study, the researchers show that a probiotic strain
of E. coli called Nissle 1917 utilizes
microcins to inhibit the pathogen salmonella and an invasive form
of E. coli (isolated from patients with inflammatory bowel disease).
In contrast, we show that in an inflamed intestine,
microcins help a probiotic strain limit the growth
of some harmful bacteria.»
In the journal Nature, Manuela Raffatellu, associate professor
of microbiology & molecular genetics, and colleagues provide the first evidence that small protein molecules called
microcins, produced by beneficial gut microbes, play a critical part in blocking certain illness - causing bacteria in inflamed intestines.
The explanation, the team figured, could be that the
microcin turned on the so - called multiple antibiotic resistance system, a pump that some bacteria use to get rid
of almost anything harmful.
A team led by microbiologist Steve Carlson at the U.S. Department
of Agriculture's Agricultural Research Service lab in Ames, Iowa, was interested in harnessing
microcins as antibiotics but wondered whether bacteria would eventually learn how to evade these too.
For that purpose, we used aggregates
of the Tau protein, implicated in Alzheimer's disease, as well as the bacterial amyloid protein
microcin (Mcc).
Probiotics possess a powerful arsenal
of their own and can produce various antimicrobials such as bacteriocins and
microcins.