Prior attempts to control ions by charging the surfaces
of microfluidic channels, however, showed that ions quickly migrated to channel walls and canceled out the voltage, shielding the rest of the liquid from further electric manipulation.
By expanding our previously developed «epidermal» electronics platform to include a complex network
of microfluidic channels and storage reservoirs, we now can perform biochemical analysis of this important biofluid,» he said.
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of microfluidic channel where electric current moves the sample onto a porous material for enrichment before isolation of P1.
Not exact matches
The basic definition
of microfluidics is «fluid flow in a
channel that has a dimension
of less than one millimeter,» according to Ben Moga, president and cofounder
of a company called Tasso Inc..
«Using a new layer - by - layer fabrication process, we created a
microfluidic environment in which TEER - measuring electrodes are integral components
of the chip architecture and are positioned as close as possible to the tissues grown in one or both
of two parallel running
channels,» said Olivier Henry, Ph.D., a Wyss Institute Staff Engineer who was the driving force behind the new Organ Chip designs.
Finding out involves passing a sample
of blood through a
microfluidic device, in whose tiny
channels cancer cells can be captured and identified.
«Faster, smaller, more informative: Device can measure the distribution
of tiny particles as they flow through a
microfluidic channel.»
Using
microfluidic design principles, Liu's group engineered vortices in their device to increase the chance that tumor cells will collide with the surface
of the flow
channel.
«Body on a chip» could improve drug evaluation: Human tissue samples linked by
microfluidic channels replicate interactions
of multiple organs..»
Malamud's
microfluidic machine uses four microscopic
channels to simultaneously scan a sample: The first looks for human antibodies to the infectious agent, the second for an antigen on the surface
of the pathogen, and the third and fourth amplify viral RNA or bacterial DNA.
A temporal array
of fluorescence images captures the migration
of a cell through a
microfluidic channel before and after division.
In an effort to overcome these limitations, a team at the Wyss Institute for Biologically Inspired Engineering led by its Founding Director, Donald Ingber, M.D., Ph.D., had previously engineered a
microfluidic «Organ - on - a-Chip» (Organ Chip) culture device in which cells from a human intestinal cell line originally isolated from a tumor were cultured in one
of two parallel running
channels, separated by a porous matrix - coated membrane from human blood vessel - derived endothelial cells in the adjacent
channel.
To study this barrier and determine why a lack
of blood flow causes it to leak, the researchers built a blood - vessel - on - a-chip model consisting
of a
channel lined with a layer
of human endothelial cells surrounded by extracellular matrix within a
microfluidic device, which allowed them to easily simulate and control the flow
of blood through a vessel and evaluate the cells» responses.
In their article, the teams describe how they used the process to etch patterns
of hollow
channels like those used to direct the flow
of liquids, such as a blood sample, in a
microfluidic device, or lab on a chip.
Sandia's SpinDx device features centrifugal
microfluidics, or «lab - on - a-disk» technology, which uses centrifugal forces to manipulate samples and reagents through
microfluidic channels implanted on disks that are
of the same size as a standard CD or DVD.
Creating organ models on a microscale has been greatly facilitated by
microfluidics, a technology developed in the 1990s that uses micropumps, valves and finely etched
channels to manipulate the movement
of fluids through a chip.
«We even succeeded in inducing much
of this differentiation process within a
channel of the
microfluidic chip, whereby applying cyclical motions that mimic the rhythmic deformations living glomeruli experience due to pressure pulses generated by each heartbeat, we achieve even greater maturation efficiencies.»
He specializes in
microfluidic technology — the flow
of fluids through
channels thinner than a human hair — to understand and control complex chemical and biological systems at critical times and locations.
FluidFM ® technology reinvents the micropipette: It unites the best features
of microfluidics and force microscopy by introducing closed microscopic
channels into force sensitive probes.
The transparent film is lined with invisible
microfluidic channels to expand designated areas
of the screen when you move the slider; the fluid is held in the case itself.