This form
of microphthalmia is inherited as an autosomal recessive trait in some breeds.
Gelatt KN, Powell NG, Huston K. Inheritance
of microphthalmia with coloboma in the Australian shepherd dog.
Not exact matches
Damage to human chromosome 9 (
of the cell's 24 pairs) where the gene that codes for E-NTPDase2 resides is known to cause eye and brain defects, such as
microphthalmia — literally, small eyes.
Molecular genesis
of cutaneous melanoma pathways; rous avian sarcoma homologue (Ras); v - raf murine sarcoma viral oncogene homologue B1 (BRAF); mitogen - activated protein kinase (MEK); extracellular signal - regulated kinase (ERK);
microphthalmia transcription factor (Mitf); phosphatidylinositol - 3 kinase (PI3K); murine v - akt oncogene homologue (Akt).
Structural eye anomalies (in particular,
microphthalmia and coloboma), cataracts, intraocular calcifications, and posterior ocular findings have been reported in infants with presumed and laboratory - confirmed prenatal ZIKV infection; however, posterior findings have been the most prevalent.21,25,28,33,35,36,41 - 43 Case series report chorioretinal atrophy, focal pigmentary mottling
of the retina, and optic nerve atrophy / anomalies.28, 34,37,41 - 43,55 Series
of 20 or more infants with presumed ZIKV - associated microcephaly report ocular findings in 24 % to 55 %.28, 33,42 In one study, testing for ZIKV IgM was performed in 24
of 40 infants (60 %) with microcephaly and the results were positive in the cerebrospinal fluid in 100 %
of those tested.42 The proportion
of infants with ocular lesions did not differ in those with and without testing.42 In that series, first trimester maternal infection and smaller head circumference significantly correlated with the presence
of abnormal ocular findings.42
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Posterior lenticonus, cataracts, and
microphthalmia were discovered in the affected dogs, most
of which were interrelated.
The entire globe
of the eye may be abnormally small (
microphthalmia).
Affected dogs present with
microphthalmia of varying...
A recessive mode
of inheritance has been suggested for congenital cataracts and
microphthalmia in the Miniature Schnauzer [112] as well as cataracts in the Entlebucher mountain dog [113], the Bichon Frise [114] and the American Cocker spaniel [115].
Examples
of the latter might include: choroidal hypoplasia in breeds not previously identified as having Collie Eye Anomaly, optic nerve colobomas,
microphthalmia, multi-focal retinopathy in breeds not yet recognized as having CMR mutations, etc..
Besides skeletal indications, there are eye disorders such as
microphthalmia (smaller eyes than they should be), lens detachments, cataracts, glaucoma, retinal defects, and nystagmus (jerking or twitching
of the eyeballs).