Sentences with phrase «of microvascular»

The Diabetes Control and Complications trial has provided conclusive evidence that strict glycemic control in patients with type 1 diabetes can both delay the onset of microvascular complications and slow the rate of progression of already established complications.

Differential Association of Microvascular Attributions With Cardiovascular Disease in Patients With Long Duration of Type 1 Diabetes

Crowson, A.N. & Magro, C.M. (1996) The role of microvascular injury in the pathogenesis of cutaneous lesions of dermatomyositis.

C - reactive Protein: The Underlying Cause of Microvascular Dysfunction in Rheumatoid Arthritis (2008) in Rhematology.

Focus on «Cyclic AMP - Rap1A Signaling Activates RhoA to Induce α2C - adrenoceptor Translocation to the Cell Surface of Microvascular Smooth Muscle Cells,» is also online (http://bit.ly/LYDXFd).

The article, entitled «Cyclic AMP - Rap1A Signaling Activates RhoA to Induce a2C - Adrenoceptor Translocation to the Cell Surface of Microvascular Smooth Muscle Cells» (http://bit.ly/N8ZzKh), appears in the Articles in PresS section of the American Journal of Physiology — Cell Physiology (http://ajpcell.physiology.org/) published by the American Physiological Society.

By focusing the analysis on date of diagnosis, this study found blood glucose control had little effect on the rates of microvascular complications, with the exception of PDR in the most recently diagnosed group.

We also examined several of the cell lines for the presence of additional receptors that are generally considered characteristic of the microvascular phenotype.

One of the primary objectives of this study was to establish a protocol to facilitate the identification and selection of microvascular endothelial cells from primary organ cultures with a high degree of precision.

We capitalized on one of the innate responses of microvascular endothelial cells, i.e., the up - regulation of cell adhesion molecules in response to inflammatory agents, to generate endothelial cell lines from different organs.

Substantial vascular damage is a major pathologic feature of both subacute and chronic stroke caused by an extended period of microvascular permeability after the BSCB loses integrity.

Intensive glycaemic control of young people diagnosed with type 2 diabetes is warranted early to minimise the risk of microvascular complications.»

With regard to microvascular complications, the authors say that «a refocus towards intensive management of hyperglycaemia at diagnosis, particularly in younger people, may be warranted if the long - term risk of microvascular complications is to be minimised.

New research published in Diabetologia (the journal of the European Association for the Study of Diabetes) shows that age (or age at diagnosis) and duration of diabetes disease are linked to the risk of death and marcovascular complications (those in larger blood vessels), whereas only diabetes duration is linked to the risk of microvascular complications (in smaller blood vessels such as those in the eyes).

By contrast, only diabetes duration is independently associated with the risk of microvascular complications, and the effects of diabetes duration are greatest at younger rather than older ages.

This means younger people with diabetes are more at risk of microvascular complications since they are more likely to have diabetes for longer over their lifetimes than those diagnosed at an older age, and should be targeted for more intensive interventions to help control their blood sugar.

Not exact matches

Microvascular disease resulting from diabetes (nephropathy, neuropathy, and retinopathy) accounts for 48 % of total diabetes costs.44 We used $ 3,557 for annual microvascular direct costs and $ 893 for microvascular indirect morMicrovascular disease resulting from diabetes (nephropathy, neuropathy, and retinopathy) accounts for 48 % of total diabetes costs.44 We used $ 3,557 for annual microvascular direct costs and $ 893 for microvascular indirect mormicrovascular direct costs and $ 893 for microvascular indirect mormicrovascular indirect morbidity costs.

The researchers were able to look more closely at the microvascular dynamics around the hippocampus, which is thought to be a critical region of seizure genesis in patients.

Studies at autopsy of people who had dementia have detected many of these so - called microvascular infarcts either by themselves or along with the plaques and tangles more typical of Alzheimer's in the brains of people with dementia.

These stroke - related alterations in the cervical spinal cord indicate pervasive and long - lasting BSCB damage that would severely affect spinal cord function, wrote the researchers, adding that the widespread microvascular impairment in the gray and white matter of the cervical spinal cord aggravated motor neuron deterioration and had the potential to cause motor dysfunction.

Specifically, the study — reported online in The Journal of Infectious Diseases — shows that E. coli K1 modulates the protein peroxisome proliferator - activated receptor - gamma (PPAR - γ) and glucose transporter - 1 (GLUT - 1) levels at the blood - brain barrier in human brain microvascular endothelial cells.

«Because our investigations on the post-stroke microvascular alterations, including BSCB damage, have just begun, many questions remain,» said senior author Dr. Cesario Borlongan, professor and director of the USF Center of Excellence for Aging and Brain Repair.

To determine whether endothelial cells — the cells that line the interior surface of blood vessels — directly influence breast cancer cell growth, they then created unique organotypic models of lung and bone marrow microvascular niches, in which endothelial cells formed blood vessel - like structures in culture as they would in the original organ.

The researchers» latest study, «Microvascular oxygen pressures in muscles comprised of different fiber types: Impact of dietary nitrate supplementation,» was published in the Journal of Nitric Oxide, Biology and Chemistry.

The epithelium's maturation into a villus intestinal epithelium with long finger - like extensions was helped along by co-culturing human intestinal microvascular endothelial cells on the opposite side of the shared matrix - coated porous membrane in the «vascular» channel where they assembled a surrogate blood vessel with a hollow lumen through which feeding medium was flowed.

To overcome these limitations, we used two - color flow cytometry to identify and select microvascular endothelial cells from primary cultures obtained from different organs of mice whose tissues harbor a temperature - sensitive SV40 large T antigen (H - 2Kb - tsA58 mice; ImmortoMice).

This latter observation adds to the expanding body of evidence indicating that brain microvascular endothelial cells lack receptors for chemically modified LDL (27, 28).

Tissue - specific microvascular endothelial cell lines from H - 2K (b)- tsA58 mice for studies of angiogenesis and metastasis

A, comparison of E-selectin expression in control colon (top left panel) to TNF - α - stimulated expression in colon (center panel) and ovarian (right panel) microvascular endothelial cells.

Normal red blood cells are about 8 microns in size, but can circulate in the microvascular system with a diameter of 1 to 2 microns because they are flexible, deformable and durable.

The selection strategy targeted cell populations expressing the inducible endothelial cell adhesion molecules, E-selectin and VCAM - 1, and proved successful in generating microvascular endothelial cell lines from a number of different organs.

Dr. King and colleagues set out to evaluate the relationship between aortic arch pulse wave velocity and subsequent cerebral microvascular disease, independent of other cardiovascular risk factors, among 1,270 participants in the multiethnic Dallas Heart Study.

The institute's physicians are experts in services such as adult reconstructive surgery, hand, upper extremity and microvascular surgery, shoulder and elbow surgery, arthroscopic surgery, pediatric orthopedics, treatment for spinal conditions, sports medicine, complete management of simple and complex fractures, incomplete bone healing, bone deformities and bone infections, and bone and soft tissue tumors.

Hyperosmolarity attenuates TNF - α — mediated proinflammatory activation of human pulmonary microvascular endothelial cells.

Specific inhibition of AQP1 water channels in human pulmonary microvascular endothelial cells by small interfering RNAs.

Researchers are building a database of DNA sequence, functional and epigenomic information, and clinical data from studies on type 2 diabetes and its macro - and microvascular complications, and creating analytic tools to analyze these data.

Rab1 GTPase promotes expression of β - adrenergic receptors in rat pulmonary microvascular endothelial cells.

Increased MAPK activation and impaired insulin signaling in subcutaneous microvascular endothelial cells in type 2 diabetes: the role of endothelin - 1

He is an expert on microvascular anatomy and patterns of angiogenesis and the effects of antiangiogenic agents in blood vessels in different organ and tissue systems.

University of Utah Define novel genes for diabetic microvascular complications

From these cell based and clinical studies, we have developed important mechanistic ideas such as activation of protein kinase C, the role of vascular endothelial growth factor (VEGF) and selective insulin resistance as some of the basic mechanisms for the pathogenesis of diabetic microvascular and cardiovascular diseases which are now widely studied by multiple laboratories.

Physicians of the Lifespan Orthopedics Institute provide diagnostic, medical and surgical treatment for musculoskeletal injuries and disorders, from simple fractures to microvascular surgery.

Clinical research has shown that MSCs can offer lasting benefit or at least some relief to patients with RA as well as addressing microvascular complications by carrying out the important jobs of:

Doctors can detect coronary microvascular syndrome if they perform a special type of angiogram, says Dr. Bairey Merz, who is working to develop new noninvasive tests for the syndrome.

Next Page: Get the right diagnosis [pagebreak] Get the right diagnosis Shortly after suffering her second heart attack on the ice, Toshawa Andrews, a figure skater from Los Angeles was finally diagnosed with a type of CAD called coronary microvascular dysfunction.

Finally, she was referred to the University of Floridas Division of Cardiovascular Medicine, which happened to be conducting the WISE study — and she was diagnosed with coronary microvascular syndrome.

A liver biopsy specimen is also taken at the time of surgery to rule out presence of other disease processes such as microvascular dysplasia.

This combination of a special diet and liver supplements will help his liver remain healthy and prevent any worsening of hepatic microvascular dysplasia, which is a common consequence to PSS.

The benefits of courses provided by the University of Illinois Microsurgery Research and Training Laboratory are the development of basic and advanced surgical techniques and techniques in microvascular and microsurgery, and to enhance clinical and research outcomes and animal care by ensuring best practices in many companion animal and laboratory animal surgical procedures.

Portosystemic Vascular Anomalies (PSVA or «liver shunts») and Hepatoportal Microvascular Dysplasia (MVD) are two common forms of liver disease.