Sixty percent
of the migraine patients indicated experiencing relief from headaches.
Neurologist Stasha Gominak came to a similar conclusion when she discovered a large portion
of her migraine patients had sleep problems that were caused by vitamin D deficiency.
«This may be a technique that will help a small number
of migraine patients who have responded to Botox, but it's certainly not a procedure for generally treating migraines,» says Dr. Kunkel, who was not involved in the new study.
More than 20 percent
of migraine patients report that they feel better even when they are given a placebo.
Not only does the study suggest these drugs are safe for this subset
of migraine patients, it could also have implications for the nearly 10 million migraine sufferers who experience auras — a disturbance in vision, touch, speech, thinking, or strength that usually precedes a migraine headache.
Not exact matches
Finally, in our study
of symptoms, we found
patients with higher unconventional natural gas development activity had higher odds
of nasal and sinus,
migraine headache and fatigue symptoms compared to those with lower activity.
Forward - Looking Statements This press release contains forward - looking statements, including, without limitation, statements relating to: the continued build - out
of Alder's executive team; Alder's growth and development; the role
of Alder's Chief Operating Officer; the continued development and clinical, therapeutic and commercial potential
of eptinezumab; the opportunity
of eptinezumab to transform treatment for
migraine patients; and the anticipated commercialization
of eptinezumab.
«Eptinezumab represents a meaningful opportunity to transform treatment for
migraine patients, and I look forward to working alongside Alder's talented team
of scientists, physicians and employees.»
Only about 200
patients or fewer will take Valeant's branded version
of the
migraine drug this year, amounting to less than $ 1 million in sales (about 0.01 %
of the company's annual revenue).
Coverage or not, Valeant said that less than 1 %
of patients still take Valeant's branded
migraine drug, with Perrigo (prgo), which makes a generic, outselling the branded version 250 to 1.
The majority
of these
patients experienced significant improvements with a reduced frequency and severity
of migraine attacks on the elimination diet (9)
It was concluded in a 2003 Italian study that «a significant proportion
of patients with
migraine may have celiac disease, and that a gluten free diet may lead to a improvement in the
migraine in these
patients.»
Yet in some
of these
patients, it also triggers a
migraine attack within six hours.
For
migraine patients with with no auras, the cause
of the pain is less apparent.
According to the authors, placebo effects can dramatically enhance the effectiveness
of pharmaceutical therapies, as shown in studies
of patients with irritable bowel disease and episodic
migraine.
In all, 51.1 million headache - related
patient visits occurred between 2007 and 2010 — nearly half
of them related to
migraine.
In fact, several national guidelines for doctors specifically discourage scanning the brains
of patients who complain
of headache and
migraine.
A team
of researchers led by Prof. Tobias Kurth, Head
of the Institute
of Public Health (IPH) at Charité — Universitätsmedizin Berlin, has now been able to establish the following: female
migraine patients have a higher risk
of stroke or heart attacks than women without
migraine.
The
patients underwent surgery on both sides
of the head, targeting the nerve implicated in temporal
migraine headaches: the zygomaticotemporal branch
of the trigeminal nerve (ZTBTN).
Patients with temporal - type
migraine derive similar and significant improvement from techniques that relieve pressure on (decompression) or remove a portion
of (neurectomy) the nerve responsible for triggering their headaches, reports the study by ASPS Member Surgeon Bahman Guyuron, MD, Emeritus professor
of plastic surgery at Case School
of Medicine, Cleveland, and colleagues.
«We hope that this assessment
of the efficacy
of currently available
migraine therapies helps
patients and their physicians utilize treatments that are the most appropriate for them,» said Dr. Silberstein.
Generally speaking, an approximately 50 percent reduction in
migraine days in at least half
of patients is seen as a realistic therapeutic goal.
«
Migraine patients are more likely to have signs and symptoms
of TMD, but the reverse is not true.
However, this research was the first to consider the frequency
of migraine attacks when analyzing its connection with TMD: eighty - four women in their early to mid-thirties were assessed, being that 21 were chronic
migraine patients, 32 had episodic
migraine, while 32 with no history
of migraine were included as controls — the results were published in the Journal
of Manipulative and Physiological Therapeutics.
Other
patients, in contrast, are treated with medications for
migraines even though they suffer from a different type
of headache, such as the more common tension variety.
The journal article concludes that an examination
of TMD signs and symptoms should be clinically conducted in
patients with
migraine.
Patients reported the severity
of their headaches on a visual analogue scale (VAS), ranging from 1 - 10, to quantify the degree
of debilitation experienced from the
migraine.
They offer a
patient - centered therapy that has the potential to break the
migraine cycle and quickly improve
patients» quality
of life,» he added.
Diagnosis is challenging, as the characteristics
of migraines and the types
of attacks vary widely among
patients.
There are cases
of patients with severe TMD who don't present with
migraine,» said Débora Grossi, the lead researcher for the study and principal investigator for the Thematic Project.
In a linked editorial, Rebecca Burch from Harvard Medical School and Melissa Rayhill from The State University
of New York at Buffalo caution that «the magnitude
of the risk should not be over-emphasized,» as «it is small at the level
of the individual
patient, but still important at a population level because
migraine is so prevalent.»
Each
of the 33
migraine trigger factors investigated correlated with
migraine attacks, in at least some
of the
patients.»
«Further studies are needed to elucidate whether vitamin supplementation is effective in
migraine patients in general, and whether
patients with mild deficiency are more likely to benefit from supplementation,» says Suzanne Hagler, MD, a Headache Medicine fellow in the division
of Neurology at Cincinnati Children's Hospital Medical Center and lead author
of the study.
«It is important for health professionals to be monitoring for the presence
of mental health problems, including anxiety disorders, in their
patients with
migraine.
Before
migraine surgery, the
patients had «extremely poor» PSEQ scores, indicating a high level
of disability.
By the early 20th century clinicians turned their attention to the role
of the blood vessels, inspired in part by observations
of strong pulsing
of the temporal arteries in
migraine patients, as well as
patients» descriptions
of throbbing pain and the relief they got from compression
of the carotid arteries.
In the 19th century medical electricity had become all the rage, and
migraine patients were routinely jolted with a variety
of inventions, including the hydroelectric bath, which was basically an electrified tub
of water.
«Our study demonstrates the high functional disability experienced by
migraine patients, compared to those with other pain conditions,» comments ASPS Member Surgeon William Gerald Austen, Jr,
of Massachusetts General Hospital.
In the 1970s cardiac
patients who also had
migraines started telling their doctors that the beta blockers they were taking to slow rapid heartbeats also reduced the frequency
of their attacks.
Occurrence
of new - onset
migraine attacks has been reported in approximately 15 percent
of patients following transcatheter ASD closure, with the majority
of initial episodes occurring within the days to weeks following the procedure.
Josep Rodes - Cabau, M.D.,
of Laval University, Quebec City, Canada, and colleagues randomly assigned 171
patients with an indication for atrial septal defect (ASD) closure and no history
of migraine to receive dual antiplatelet therapy (aspirin + clopidogrel [the clopidogrel group], n = 84) or single antiplatelet therapy (aspirin + placebo [the placebo group], n = 87) for 3 months following transcatheter ASD closure.
«We hope this review
of medical treatments will serve as a guide for doctors and
patients on how to interpret new findings, especially regarding four treatment options that doctors have commonly used for their pregnant
patients with
migraines,» said Rebecca Erwin Wells, M.D., assistant professor
of neurology at Wake Forest Baptist and lead author
of the paper.
In a study
of 588
patients who attended an outpatient headache clinic, more frequent
migraines were experienced by participants with symptoms
of anxiety and depression.
Her eloquent account flits between philosophy, science and anecdotes from the writing classes she runs for psychiatric
patients, as well as her own experiences
of those seizures,
migraines, voices in her head and a heightened perceptual awareness.
To quantify the difference, a 2013 meta - analysis looked at placebo effects in 79 studies
of migraine prevention: sugar pills reduced headache frequency for 22 percent
of patients, fake acupuncture helped 38 percent, and sham surgery was a hit for a remarkable 58 percent.
Topamax, an epilepsy drug from Ortho - McNeil Pharmaceutical, has proven extremely effective on
migraines in clinical trials: Half
of all
patients have reported a 50 percent reduction in the frequency
of migraines, and more than a quarter have a reported 75 percent reduction.
The research team found that, in a select group
of patients, incisions through the upper eyelid resulted in equally effective release and deactivation
of the nerves involved in
migraines.
More than 90 %
of the
patients who underwent this surgery to decompress the nerves that trigger
migraines experienced relief and also got a bonus cosmetic eyelid surgery.
Dr. Oren Tessler, Assistant Professor
of Clinical Surgery at LSU Health Sciences Center New Orleans School
of Medicine, is part
of a team
of plastic and reconstructive surgeons who report a high success rate using a method to screen and select
patients for a specific surgical
migraine treatment technique.
Shannon entropy analysis
of FA histograms performed better than mean FA as a diagnostic test to differentiate between concussion
patients and controls and also performed better in determining which concussion
patients developed post-traumatic
migraines.