Sentences with phrase «of migrating cells»

A role for actin arcs in the leading - edge advance of migrating cells.

The technique offered precise localization of dynamic microtubule plus - end hub protein EB1 dimers, and their distinct distributions at the leading edge and cell body of migrating cells, the researchers report.

Numbers of migrating cells, shown in red, are greatly reduced when the molecule FOX01 is deleted (right column).

Not only do birds flock together but so too do countless examples throughout life, from the macroscopic to the microscopic, including schools of fish, colonies of bacteria, groups of migrating cells and even some proteins.

In 3D matrices, even though the whole surface of a migrating cell is available for interacting with the ECM, it is unclear whether discrete adhesion structures actually exist.

In 2D, only the ventral surface of a migrating cell is in contact with the ECM, where cell - matrix adhesions are assembled.

Not exact matches

This makes me happy: Microglia cells migrate into tumors and supply cancer cells with a substance needed for the repair of DNA damage.

Tattoos are permanent because the ink remains walled off within the body via the body's inflammatory process, making the possibility of the ink migrating into the mother's blood plasma and then into the milk - making cells of the breast, next to impossible.»

These cells are unique to this stage of development, and will migrate to the baby's bone morrow soon after birth, transforming themselves into various types of blood - making cells.

Based on animal models, including a primate model, it is hypothesized that the cells remain unharmed in the digestive tract of the infant then enter the bloodstream, migrate to different organs, and there provide active immunity.54

A few years ago, Cornelia Halin, professor at the Institute of Pharmaceutical Sciences, and her team observed that dendritic cells migrate in a zigzag pattern within lymphatic capillaries (see ETH Life article from 09.08.2012).

A research team at the University of California, Riverside has discovered a way for chemotherapy drug paclitaxel to target migrating, or circulating, cancer cells, which are responsible for the development of tumor metastases.

One research group investigating this possibility followed the activity of fetal microchimeric cells in a mother rat after the maternal heart was injured: they discovered that the fetal cells migrated to the maternal heart and differentiated into heart cells helping to repair the damage.

Neural crest cells migrate to different parts of an embryo and give rise to several tissues including the bone and

The authors defined the gene signature of the different regions surrounding the wound to uncover the gene expression signature of the cells that actively divide and those that migrate to repair the wound.

One of the key questions in biology is to identify how tissues are repaired after trauma and understand how stem cells migrate, proliferate, and differentiate to repair tissue damage.

Cells may migrate through the placenta between the mother and the fetus, taking up residence in many organs of the body including the lung, thyroid, muscle, liver, heart, kidney and skin.

Compared with unheated mice, the animals with the faux fever had twice as many white blood cells migrating out of the blood vessels and into the lymph tissue that lines the skin and gut, which is where they need to be to attack incoming pathogens.

And in a new study, Cornell University researchers report that tumor cells take advantage of already - cleared paths to migrate unimpeded.

In experiments on zebrafish, Freiburg researchers have demonstrated that the same proteins that lead to the formation of metastases in humans also cause the cells to migrate during embryonic development.

Equipped with this receptor, the cancer cells are able to recognise and migrate towards a gradient of a substance that is secreted from the lymphatic vessels and binds to the receptor.

«The potential advantage of stem cells,» says Eugene Redmond, a professor of neurosurgery at the Yale University School of Medicine and the lead author of that study, «is that they still have the potential to migrate and position themselves in appropriate places depending on what signals are there [in the brain].»

On average, about a third of cells that left the tumor migrated as bicolored clumps of cells.

The data that the breast cancer cells spread more successfully in clumps are compelling, D'Souza - Schorey said, but no one yet knows whether cells from other types of cancer also need help to migrate.

During normal brain development in the first weeks of life, precursor cells in the SVZ in the piglets give birth to neurons that migrate primarily to the prefrontal cortex, the team reports today in Science Translational Medicine.

«Disturbances to these processes may cause neuronal stem cells to develop into different types of cells or may cause neurons to migrate to different locations in the brain, changing neuronal circuitry and potentially leading to behavioral disorders like schizophrenia.»

During the active disease stage of JIA, these cells expand, grow in number, re-circulate through inflamed areas of patients» body, and migrate to the connective tissue of patients» joints.

In mice with pancreatic tumors, Kalbasi and other members of the team found relatively high levels of inflammatory compounds including CCL2, the signaling molecule that activates CCR2 on monocytes and macrophages to make these cells migrate to tumors.

Although NRF2 has many benefits, loss of NRF2 regulation leads to high levels in certain cancer cells, such as some lung cancers, and it may help them migrate, Zhang says.

Further experiments revealed that injured cells initiate a wave of elevated calcium ion concentration that travels through the brain, and that the microglia only begin migrating when the wave reaches them.

In their report published in Science Immunology they describe how expression of a specific molecule — complement C5a — is required to cause the immune cells called neutrophils to adhere to joint surfaces and migrate into the joint, a process known to set off the inflammatory cascade.

The research team found that a key downstream effect of depleting the protein was that particular cells failed to migrate to the heart, where they would usually have played key roles in developing heart structures.

They might be put to use right away to track cultures of immune cells as they migrate in response to chemical stimuli.

Last year, the same researchers showed that the trigger came from cells in a structure in the embryonic brain called the floor plate, which dopamine cells brush past while migrating to their eventual home in a part of the brain called the substantia nigra.

Working with human breast cancer cells and mouse models of breast cancer, scientists identified a new protein that plays a key role in reprogramming cancer cells to migrate and invade other organs.

Others become part of the path itself, as migrating axons grab the cells and climb them like ropes.

This suggests that the combination of BMPs and retinoic acid is the critical signal that reprograms neural crest cells after they migrate — and ultimately shape the face, Richman says.

T lymphocytes, immune cells which circulate in the blood, must migrate across the walls of blood vessels in order to reach inflamed tissue.

By producing significant amounts of IL - 9, the MMC9 cells caused mastocytosis and the production of mast cells, which may migrate out of the intestines to other organs as they secrete histamines and other molecules that cause anaphylaxis.

A 2010 study in Stem Cells and Development showed that fetal cells can migrate to the brain of a mother mouse and mature into neurons, Nelson Cells and Development showed that fetal cells can migrate to the brain of a mother mouse and mature into neurons, Nelson cells can migrate to the brain of a mother mouse and mature into neurons, Nelson says.

The team of medical and engineering researchers at The Ohio State University previously determined that modifying a single gene to reduce this protein's level in breast cancer cells lowered the cells» ability to migrate away from the tumor site.

By masking JAM - C, H225 was able to prevent the cells from migrating out of the blood vessels.

Finally, says Evrony, the findings provide a proof - of - principle for a systematic way of studying how brain cells disperse and migrate during development, «something that has not been possible to do before in humans,» he says.

Understanding how cancer cells are able to metastasize — migrate from the primary tumor to distant sites in the body — and developing therapies to inhibit this process are the focus of many laboratories around the country.

«We think this could be one way cancer cells actually migrate from one place to another to induce metastasis,» says Besim Ogretmen, Ph.D., senior author for this study, director of the Developmental Cancer Therapeutics Program at the Hollings Cancer Center and professor of Biochemistry and Molecular Biology at MUSC.

In contrast to other cell - movement systems in which cells migrate along fibers or reorganize the extracellular matrix, the «hand - over-hand» pulling causes the shortening and bending of platelet - attached fibers.

The cells originate outside the central nervous system in the ectoderm of the body wall and appear to migrate to their final locations within the central nervous system by crawling along strands of connective tissue.

When Gillian Bates at Guy's Hospital, London and Stephen Davies at University College in London and their colleagues examined the brains of transgenic mice endowed with a DNA encoding 150 of these glutamine repeats, they found that the protein started out, at birth, in the cytoplasm of the animals» brain cells and then gradually migrated to cell nuclei and clumped there.

TB is known for trying to block activation of T cells by infected dendritic cells, two kinds of which are primarily involved in fighting infection: dendritic cells that migrate from the lungs to the lymph nodes, and those that already reside in the lymph nodes.

Depending on the concentration of cannabinoids and the activity of two different receptors, the islets became larger or smaller, while the alpha cells, usually located outside the islets, were able to migrate inside,» explains Dr. Katarzyna Malenczyk fom the Nencki Institute, the first author of the publication.