Sentences with phrase «of model deficiencies»

It's unlikely, because attribution procedures are designed to consider the possibility of model deficiencies and are tested to make sure climate models simulated internal variability well enough for attribution studies.

Not exact matches

Just as science must constantly revise its models so as to surmount the deficiencies of its abstract (usually mathematical) models of nature, so also religions are called upon continually to revise their enigmatic representations of cosmic significance in keeping with primary perceptions intuition of an ongoing cosmic adventure.

Suffice it to say that ignoring the evidence indicating evolution and invoking supernatural mechanisms to account for deficiencies in creationist models suggests the rejection of evolution is principally based in an unreasonable doubt born of a priori religious faith.

It means a real equalisation of possibilities of each citizen to live a life according to the chosen model, without deficiencies and disadvantages provoked by the privileges of others.

Golden Rice is a killer of Biodiversity, and a killer of alternatives because it extends the food and agriculture model that is depriving people of the diversity that is vital to removing nutritional deficiencies.

In multivariable models, breastfeeding without supplementation among infants and lower milk intake among toddlers were significant predictors of vitamin D deficiency.

Multiple logistic regression models, evaluating predictors of vitamin D deficiency with adjustment for other predictors, are summarized in Table 4.

Each model is different in terms of scientific, humanistic, economic and outcome efficiencies and deficiencies, as well as effect on providers and recipients of these models of care.

Emphasizing that the citizens - driven policing model was the way forward, the IGP said, «This model will address the manpower deficiency challenge in the Nigeria Police as every citizen plays the role of a police officer.»

Armed with their model, the researchers want to identify and understand deficiencies in state - of - the - art numerical weather models that prevent them from predicting weather on these subseasonal time scales.

The findings, published online in Nature the week of May 12, 2014 marks the first time a genetic model for brain DHA deficiency and its functions in the brain has been made available.

The current study showed that a deficiency of both SRC - 1 and SRC - 2 inside the fetus» lungs drastically decreased the production of SP - A and PAF, causing a one - to two - day labor delay in mouse models, comparable to a three - to four - week labor delay in women.

«In our study, we used two mutant strains of the model plant Lotus japonicus to investigate whether the host plant actively makes up for this deficiency.»

«Prior analyses have found that climate models underestimate the observed rate of tropical widening, leading to questions on possible model deficiencies, possible errors in the observations, and lack of confidence in future projections,» said Robert J. Allen, an assistant professor of climatology in UC Riverside's Department of Earth Sciences, who led the study.

«Neurons become increasingly more complex in their extensions and connections as the brain matures, and the maturational delays reported previously in animal models and human behavioral studies of iron deficiency would predict that lower iron intake would produce neurons in cortical gray matter that are structurally less complex and more immature.

Another key finding was observing the inhibitor effect on tumor models with a gene PTEN deficiency as a biomarker — of huge interest because PTEN, a tumor suppressor, is known to be defective in as many as half of all advanced solid tumor cancers.

Effect of increased concentrations of atmospheric carbon dioxide on the global threat of zinc deficiency: a modelling study.

Findings from the PAFR - KO genetic model reveal that PAFR - deficiency causes brown adipose tissue (BAT) dysfunction, which converges to induce the development of obesity, due to impaired thermogenic activity of BAT.

Bone loss in models of leptin or leptin receptor deficiency has been linked with lower osteoblast activity (9, 14), suggesting that cellular leptin resistance in obesity might reduce bone formation.

Because PD - L1 / programmed cell death (PD - 1) deficiency accelerates development of diabetes in mouse models, Nasr et al. hypothesized that a defect in the PD - L1 / PD - 1 pathway may underpin the hyperglycemia observed in the nonobese diabetic (NOD) mouse model.

BACE1 deficiency rescues memory deficits and cholinergic dysfunction in a mouse model of Alzheimer's disease.

Early gene therapy confers structural and functional rescue to cones in two models of RPE65 deficiency: rd12 and Rpe65 - / - Rho - / - mice.

DGKζ, a lipid kinase, phosphorylates the second messenger DAG, terminating DAG - mediated activation of RasGRP1 and PKC - θ, whereas Cbl - b, an E3 ubiquitin ligase, facilitates ubiquitination and subsequent degradation of the p85 subunit of PI (3) K. Previous studies have evaluated numerous aspects of T cell biology in the two models (16 — 18, 25, 38), but the signaling and functional effects of DKGζ deficiency and Cbl - b deficiency in T cells had not been directly compared.

Furthermore, SMN deficiency disrupts Stasimon expression in the neurons of the sensory - motor circuit in a mouse model of SMA.

In this study, we investigated whether physical exercise could increase progranulin levels and thus ameliorate progranulin deficiency in Grn + / − mice, a model of FTD due to GRN mutations.

Several mouse models of DJ - 1 deficiency have been developed, but they do not have dopaminergic neuron cell death in the substantia nigra pars compacta (SNpc).

This could be because of the structural deficiency of the model, or because of errors in the data, but the (hard to characterise) uncertainty in the former is not being carried into final uncertainty estimate.

Elisabeth Larsen Mouse models for flap endonuclease (FEN1) and 8 - oxoguanine DNA glycosylase 1 (OGG1) deficiency Faculty of Medicine, University of Oslo Supervisor: Arne Klungland

SAN FRANCISCO, CA — Using animal models, scientists at the Gladstone Institutes have discovered how a protein deficiency may be linked to frontotemporal dementia (FTD)-- a form of early - onset dementia that is similar to Alzheimer's disease.

379/11: 30 A mouse model of cblC deficiency displays reduced survival, growth retardation, and combined methylmalonic acidemia and hyperhomocysteinemia.

Hypothetical model of most representative factors for conceptus survival and pathological deficiencies in SCNT - derived pregnancies during the periimplantation period.

The group has further proved that administering growth hormone alleviated the NASH conditions caused by adult growth hormone deficiency, and treatments of GH and IGF - I were effective when applied to model animals with growth hormone deficiency.

Previous experimental studies showed that diet - induced magnesium deficiency led to elevated serum concentrations of inflammatory cytokines in rodent models (30 — 33).

My next project was to set up a human experimental model of mild zinc deficiency where there was nothing abnormal except zinc intake.

Loss of skeletal muscle in models of leptin deficiency has been linked with imbalances between hypertrophic and atrophic myokines (34, 55 — 57).

The author, R. Barker Bausell, a biostatistician in the School of Nursing at the University of Maryland, has come to the conclusion that classroom instruction is hopelessly obsolete, and that the answer to the deficiencies of our educational system is the tutorial model.

Finance experts retained by the state modeled their practices after those of the Food and Drug Administration, Air Traffic Control Administration, and Veterans Administration, all of which have relied for years on professional judgment panels when faced with information deficiencies.

However, upon close analysis, one can begin to detect deficiencies in the standards - and accountability - based model and problems for its future as the primary determinant of progress in student achievement.

This powerful scientific knowledge is largely underutilized in new education models and approaches, and this deficiency is a major factor in the persistent problems of excellence and equity from cradle to career.

The new Pilot addresses every conceivable deficiency of the outgoing model while building on its inherent strengths.

Even the Taurus» looks, a long - standing deficiency on Taurus models of the past, has been improved tremendously to the point that it looks a lot more aggressive than the Malibu.

For the 2003 model year, Toyota has introduced an all - new Corolla that addresses many of the car's deficiencies.

This model allows noninvasive visualization and analysis of stifle biomechanics, simulates the intact and CRCL - deficient stifle, and was utilized to investigate anatomical characteristics and biomechanical parameters, such as ligament stiffness and tibial plateau angle to gain an understanding of their role in producing CrCL deficiency.

That «deficiency» in Figure 4 reminded me of a graph linked at Neven's site which has such a «We are here» marker superimposed on a now - outdated RealClimate graph, only that graph was for Extent not Volume & so importantly compares a measured quantity rather than a model output as is PIOMAS.

Some attribution assessments that link events to dynamically driven changes in circulation have been criticized on the grounds that small signal - to - noise ratios, modeling deficiencies, and uncertainties in the effects of climate forcings on circulation render conclusions unreliable and prone to downplaying the role of anthropogenic change.

The weakening of the Walker circulation arises in these models from processes that are fundamentally different from those of El Nià ± o — and is present in both mixed - layer and full - ocean coupled models, so is not dependent on the models» ability to represent Kelvin waves (by the way, most of the IPCC - AR4 models have sufficient oceanic resolution to represent Kelvin waves and the physics behind them is quite simple — so of all the model deficiencies to focus on this one seems a little odd).

The fact that our model does a surprisingly good job with simulating the last 400,000 years of global ice volume, with no change in model physics and only one linear change in boundary conditions, argues for the fact that, despite plausible deficiencies, we have done a surprisingly good job of simulating the pattern of fluctuations in ice volume.

When we do, no matter how good the climate model is it will not be able to overcome deficiencies in our ability to predict the things that affect climate — solar activity, ocean cycles, etc — and it will not be able to overcome deficiencies in our understanding of how things that affect climate actually work — solar activity, Earth orbital changes, etc..

Lastly, deficiencies in a match of models vs. observations (whether a forecast, or a simulation of a past climate event) may not be entirely due to problems inherent within the model, but a problem in the experimental setup, or at least a difference in what the modeler was trying to answer.

Each use of models must be judged on its merits rather than via pejorative generalizations, but I hesitate to trigger another landslide of commentary about the deficiencies of models, so I won't pursue that point further.