Sentences with phrase «of model mice»

Compared with those of control animals, the hippocampi of the model mice had fewer gamma waves during sharp - wave ripples, but gamma waves during theta waves were unaffected.

On this week's show: Kelly Servick talks about how the microbiomes of model mice can change the outcomes of experiments, and a daily news roundup

Not exact matches

«There's no mouse model and no human model of the ideas,» she said.

Currently SQZ is developing its technology further using mouse models and human blood experiments to understand its mechanisms of action more fully.

Pharmaceutical scientists hope for a moment of chemical serendipity, despite often not fully understanding the complexity of the biological mechanisms they're targeting — or why something might fail in humans when it works so neatly in a mouse model.

He conducted his postdoctoral research at Brigham and Women's Hospital / Harvard Medical School, where he researched the role of the Wnt signaling pathway in mouse models of kidney disease, and was part of a team that discovered a stem cell subtype responsible for solid organ fibrosis.

Using a «gnotobiotic mouse model» — where mice were «colonized with a synthetic human gut microbiota composed of fully sequenced commensal bacteria» — Desai et al reported on the effects of different diets with different fibre content.

Capsaicin additionally produced a significant deceleration of the development of prostate tumors created simply by those human cell lines grown in mouse models.

A recent study assessing the oncogenic potential of capsaicin revealed that dermal application of capsaicin did not lead to the induction of preneoplastic or neoplastic skin lesions in the Tg.Ac mouse model (47).

UT Southwestern biochemists studying mouse models found that the two proteins − steroid receptor coactivators 1 and 2 (SRC - 1 and SRC - 2)-- control genes for pulmonary surfactant components that promote the initiation of labor.

«We also confirmed a role in PDAC tumor maintenance as inhibition of PRMT1 in patient - derived mouse models significantly inhibited tumor growth and extended survival,» said Giuliani.

Other rows are eyes from three different mouse models of diabetes.

All of the symptoms, including increased weight, were erased in the female mouse model.

In a University of California, San Diego School of Medicine study published July 13 in the online journal Nature Neuroscience, a research team led by Takaki Komiyama, PhD, assistant professor of neurosciences and neurobiology, reports that in mouse models, the brain significantly changed its visual cortex operation modes by implementing top - down processes during learning.

New research shows that in a mouse model of childhood absence epilepsy, brain activity is perturbed between seizures.

In 2015, Noebels and Dr. Isamu Aiba, a research fellow in neurology at Baylor, published a paper in Science Translational Medicine in which they described in a mouse model what would happen if spreading depolarization, the blackout of brain activity, occurred deep in the brainstem, which controls the heart beat and breathing.

«The successful restoration of normal function demonstrated in the mouse models suggests that if we can develop therapies to address the loss of Mecp2,» Baylor's Zoghbi says, «we may be able to reverse neurological damage in children and adults with Rett, autism and related neuropsychiatric disorders.»

«It would be interesting to model some of these diseases in mice and see if supplementing NMN provides any benefit to their behavior or memory.»

The resulting inoculation looks promising in both ferrets and mice, the most commonly used models of influenza infection.

In the new work, published June 10 in the journal Scientific Reports, Zhao, Reid and colleagues used a highly sensitive probe to measure electrical fields in the corneas of isolated eyes from three different lab mouse models with different types of diabetes: genetic, drug - induced and in mice fed a high - fat diet.

The researchers tested their drug compound, Targapremir - 210, in mouse models of triple negative breast cancer.

Jeffrey Noebels and his team at Baylor College of Medicine in Houston, Texas used two genetic mouse models of absence epilepsy and compared them to unaffected mice.

Gene therapy delivered to a specific part of the brain reverses symptoms of depression in a mouse model of the disease — potentially laying the groundwork for a new approach to treating severe cases of human depression in which drugs are ineffective.

The researchers collected samples of indoor dust from 11 homes in North Carolina and tested extracts from the samples in a mouse pre-adipocyte cell model, 3T3 - L1 cells, often used to test compounds for potential effects on the accumulation of triglycerides, a type of fat.

A new mouse model of a genetically - linked type of autism reveals more about the role of genes in the disorder and the underlying brain changes associated with autism's social and learning problems.

Speaking about the research, Dr Hawkins said: «We were really surprised that loss of PTEN caused such a dramatic increase in PI (3,4) P2 in our mouse model of prostate cancer.

A second mouse model, induced by overexpression of IL - 17 in skin, also shows bone loss, and suggests that the deregulation of the protein is sufficient to cause this effect.

Using the mouse as an experimental model, LMU neurobiologist PD Dr. Conny Kopp - Scheinpflug and her research group have now demonstrated that the activity of nerve cells in the auditory system has a direct effect on myelinization — higher levels of activity correlate with the formation of thicker myelin sheaths.

«The mouse is a particularly suitable model in which to study the development of the auditory system, because newborn mice are deaf and only begin to perceive acoustic signals at 12 days after birth.

For researchers using mouse models to study a variety of cancers, including lymphoma, melanoma, breast, and prostate cancers as well as autoimmune and infectious diseases, the panel facilitates a highly sensitive and high - throughput investigation of biomarkers associated with disease progression.

Using a mouse model that expresses an altered form of the normal human prion protein, researchers at University of California, San Diego School of Medicine have determined why the human proteins aren't corrupted when exposed to the elk prions.

Examining the safety of respiratory and intravenous inoculation of Bdellovibrio bacteriovorus and Micavibrio aeruginosavorus in a mouse model.

These findings allowed researchers to create a chimera virus: a mouse virus with a human viral gene that can be used to test molecules that inhibit human LANA protein in an animal model of disease, treating not only human herpes virus infection but also its associated cancers.

«Indeed, in a second tumor model of metastatic breast cancer, we demonstrated that mice treated with the EphA2 - targeting paclitaxel conjugate presented nearly no lung metastases, while a large numbers of lesions were observed in both untreated mice and in mice treated with just paclitaxel.»

Led by graduate student Patrick O'Hern, the team at Brown and the University of Cologne in Germany uncovered a complex cause - and - effect sequence in both C. elegans worm and mouse models of SMA.

Using a flexible mouse model, her team set out to determine whether anything could be done to restore memory «after a significant number of neurons are lost in the brain.»

Researchers from Instituto de Medicina Molecular (iMM) Lisboa have created a chimera virus that allows the study of molecules to treat cancers caused by human herpes virus infection in mice models of disease.

PDX models are created by implanting cancerous tissue from a human primary tumor directly into immunodeficient mouse or rat models, enabling acceleration of oncology research or drug discovery and development programs.

Recent collaborative work between UCR and Cedars - Sinai Medical Center in Los Angeles demonstrated that in animal models of human breast cancer, mice treated with 123B9 that was conjugated with paclitaxel had significantly fewer circulating cancer cells in the blood compared to mice that were not treated or even treated with paclitaxel alone.

The behavioral tests used here modeled one dimension of the disease — an inability to experience pleasure from normal activities — but not others, such as stress and anxiety, and probably tap into different brain mechanisms in mice than in humans, he says.

Scientists at Duke Health who developed the new model also discovered that targeting a brain receptor in mice with this type of autism could ease repetitive behaviors and improve learning in some animals.

Burd and her colleagues used a mouse model to study what happens to the brains of those offspring as they age into adulthood to see if the effects persisted.

«Our research is the first to study Zika infection in a mouse model that transmits the virus in a way similar to humans,» explains Alysson R. Muotri, Ph.D., professor and director of the Stem Cell Program at UC San Diego and co-senior author of the study.

Prof. Marine and his team generated a refined mouse model that faithfully reproduces the early stages of melanoma development in humans.

Researchers have used CRISPR to treat an adult mouse model of Duchenne muscular dystrophy.

So far, gene therapy attempts have only resulted in partial improvements of hearing in mouse models of specific human deafness forms that did not include severe anomalies in hair cell structure.

To study this question, the researchers focused on the grey mouse lemur, a small primate whose lifespan (around twelves years) makes it a very good model for the study of aging.

That, he says, suggests that the widely used mouse model of cystic fibrosis «might not be appropriate.»

Gandhi's research team is the first to develop a mouse model with depleted levels of a protein called augmenter of liver regeneration (ALR), which is essential for the survival of liver cells called hepatocytes.

CSIRO senior scientist and co-author of the paper Dr Eva Plaganyi said the research was enabled through a complex ecosystem model nicknamed «MICE», an acronym for Model of Intermediate Complexity for Ecosystem Assessmmodel nicknamed «MICE», an acronym for Model of Intermediate Complexity for Ecosystem AssessmModel of Intermediate Complexity for Ecosystem Assessments.