Sentences with phrase «of more tumors»

Not exact matches

Immunotherapy differs from more traditional cancer treatments, such as surgery (cutting malignant cells out of the body), chemotherapy and radiation (poisoning the deadly mutants), and even the newer, more precise molecular drugs that attempt to jam the protein signals that tell tumor cells to keep dividing and conquering.

And using lower levels of Yervoy in combination with Opdivo actually prompted more tumor shrinkage, underscoring the fact that dosing is a critical and unpredictable factor for immunotherapies.

When Jedd Wolchok, a cancer doctor and immunologist leading a Yervoy trial at Memorial Sloan Kettering, examined a melanoma patient's scan 12 weeks after he'd received his course of treatment, the results were utterly disappointing — just like those of any other metastatic patient in the final throes of the disease: The tumors had gotten bigger, and there were more of them.

Yet since 1985, there have been only four FDA - approved drugs to treat the more than 120 different types of brain tumors, according to the National Brain Tumor Society.

Patients in the trial had advanced NSCLC, and their tumors tested positive for PD - L1 levels of 50 % or more.

As a cancer researcher, do you think the mechanisms of tumor growth are somehow changing to come into line with your perceptions, or is it possible that the process of our learning more about DNA mutations and cell architecture and nutrient exchange and epigenetic effects make it possible for us to inch ever closer to understanding that which is already going on under our noses?

I told her that there was a suggestion of a possible tumor and wondered if anyone could give me more details on the situation.

Surely, for a patient who can no longer assimilate food, N&H provides no benefit; similarly, some stomach cancer cases result in feeding the tumor instead of the patient; and there are those who are so fragile that almost any invasive insert causes more problems than it relieves.

To Shiney: First of all, the «knot» on the side of the head of your pastor's wife was more than likely a cyst — not a tumor.

But his sense of humor Was more like a tumor And his political judgment was nil.

According to one study, however, cysteine supplementation with whey protein actually lowered levels of glutathione in some tumors, making them more susceptible to chemotherapy.

Coapplication of capsaicin with TPA to the dorsal surface of either TRPV1 / WT or KO mice induced significantly more and larger skin tumors compared with TPA treatment alone (Table 1; Fig. 1A — C).

Topical application of capsaicin on the dorsal skin of 7,12 - dimetylbenz (a) anthracene — initiated and TPA - promoted TRPV1 wild - type (WT) and TRPV1 knockout (KO) mice induced more and larger skin tumors in TRPV1 / KO mice, suggesting a TRPV1 - independent mechanism.

The story is an allegory for the death of Pirola's own father, John, who suffered for years through searing neuropathic pain as a result of a brain stem tumor, and over several years, underwent more than 10 brain / skull - based surgeries.

The study indicated that even a small period of breastfeeding reduces the risk of these stubborn tumors, which are more common in younger women and generally have a poorer prognosis than other subtypes of breast cancer.

The introduction of infant formula to babies» diets changes the infants» gut microbiome, thus affecting the response of the infant immune system to pathogens.47 - 51 A greater amount of natural - killer cells, suggesting a more mature immune system, have been found in breastfed infants than in formula - fed infants.52 In addition, pH level in the stomach of breastfed children is better for the promotion of the protein - lipid α - lactalbumin (termed HAMLET), which induces apoptosislike death in tumor cells.51, 53

Former President Jimmy Carter said that his most recent brain scan showed no signs of cancer, more than three months after he began treatment for four melanoma tumors.

After adjusting for age, tumor location, and stage, researchers from Cleveland Clinic's Dermatology & Plastic Surgery Institute discovered that women diagnosed with malignant melanoma during their pregnancy or within one year of giving birth were 5.1 - times as likely to die, 6.9 - times as likely to experience metastasis, and 9.2 - times more likely to have a recurrence.

Triple negative patients usually have shorter survival time after diagnosis of brain metastasis, suggesting that these tumor cells adapt much more readily once they've moved to the brain.

As researchers learn more about genetic profile of various cancers, other work is charging ahead to deliver personalized vaccines targeted to a patient's own tumor cells

«This research represents a big step forward in understanding why some tumors are more aggressive than others and being able to predict rationally which neoantigens will be the most effective at stimulating an immune response,» said Dr. Balachandran, a member of the David M. Rubenstein Center for Pancreatic Cancer Research at MSK, and corresponding author of the companion study in Nature.

Even after initial purification of the sample, liquid biopsies typically contain much more nucleic acid from healthy cells than from tumors.

While more sensitive assays have enabled doctors to take smaller samples of some types of solid tumors, oncologists have long dreamed of avoiding traditional biopsies altogether.

More precise application of immuno - therapies and the development of new approaches requires knowing the detailed immune landscape of individual patients and tumors.

Many biomarkers are available for estimating tumor mass, but a possibly more important aspect of a tumor's pathology is how aggressive it is and how fast it is growing.

Among the advances that have already been made are linear accelerators that generate higher - energy radiation beams, and more versatile patient tables that enable radiation doses to be delivered to the tumor from a variety of angles and directions.

Recent advances in the understanding of cancer have led to more personalized therapies, such as drugs that target particular proteins and tests that analyze gene expression patterns in tumors to predict a patient's response to therapy.

Once they have consumed all the oxygen and nutrients in the original tumor site, the cancer cells travel to other parts of the body (metastasize) to find more nourishment.

Overall, 34 percent of patients showed an objective response, meaning that their tumors shrank by more than 30 percent, and did not re-grow.

«It was really surprizing to realize that oncogenic Pik3ca in basal cells induced the formation of luminal tumours, while its expression in luminal cells gave rise to heterogeneous and more aggressive tumors including basal - like tumors,» comments Alexandra Van Keymeulen, the first author of the paper.

Many more microchimeric cells are found in the blood of healthy women compared to those with breast cancer, for example, suggesting that microchimeric cells can somehow prevent tumor formation.

«However, the immense complexity of tumors and their genomic aberrations will require sophisticated computer technologies for optimal interpretation, and patients need access to more clinical trials and to targeted drugs.»

This additional information will help in the next steps of the research, which involve more detailed study of the PD - 1 at different points in its pathway and with different viral or tumor loads.

In the presence of these drugs tumors grow faster and develop more extensive networks of the blood vessels they rely on to feed their expansion — a process called angiogenesis, says Jonathan Moss, an anesthesiologist at the University of Chicago (U. of C.) Medical Center.

Working from more than a dozen X-ray images to piece together a full image of the tumor and organs of the body, Goitein had to make thousands of calculations for each patient to figure out the angle, strength and penetration of the beam.

For example, HPV - inactive tumors were 17 times more likely to contain disrupting TP53 gene mutations than HPV - active cervical cancers, rendering unnecessary the expression of the HPV E6 oncogene.

Additionally, lung cancer patients who have high levels of YAP1 in their tumors are more likely to have a poorer prognosis than patients with low levels of YAP1.

Virtual - reality technology is giving surgeons the equivalent of x-ray vision, helping them to remove tumors more effectively, to minimize surgical wounds and to avoid damaging critical tissues

The identification of the cancer cell of origin has important clinical implications, as it enables doctors to detect malignancies earlier and predict tumor behavior more accurately.

Conventional radiation with photons gave way to intensity - modulated radiation therapy, or IMRT, in which more precise beams of photons could be moved dozens or hundreds of times with varying intensities, attacking tumors in three dimensions with safer high doses.

Conventional, high - dose chemotherapy treatments can cause the fibroblast cells surrounding tumors to secrete proteins that promote the tumors» recurrence in more aggressive forms, researchers at Taipei Medical University and the National Institute of Cancer Research in Taiwan and University of California, San Francisco, have discovered.

«Just as normal cells with the same genome differentiate into many different cell types, a single tumor characterized by specific genetic mutations can contain many different types of cells — stem - like and more differentiated cells — with the difference being rooted in their epigenetic information.

Looking to target a key pathway in order to interfere with the processes that lead to tumor spread, a research team led by Irwin H. Gelman, Ph.D., of Roswell Park Cancer Institute (RPCI) has identified a new suppressor of cancer metastasis that may point the way toward development of more effective treatments for prostate cancers and other malignant solid tumors.

Their analysis of more than 4,000 individual tumor cells, the largest effort to date in brain tumors, finds three developmental categories of cancer cells — one resembling neural stem cells and two characterized by sets of genes indicting paths towards differentiation.

With that knowledge, they screened more than four dozen monoclonal antibodies — unique agents that can stop cells from growing or forming tumors and can be mass produced — before finding two that block tumor creation in both types of cancer.

«As well as finding more effective treatments for advanced melanoma, we also need to stress the importance of early diagnosis, detecting tumors before they have a chance to spread.»

We found that the inflammation unfortunately gets hijacked by tumor cells that are able to grow faster and penetrate deeper because the blood vessels in the brain are more permeable than in any other part of the body.

More light leads to a greater flow of calcium, so the researchers are able to finely tune the calcium - dependent actions of immune cells to fight against invading pathogens or tumor cells.

Our specialty is accustomed to more than its share of depressing outcomes, from lives cut short by brain tumors to minds devastated by head injury.

In past imaging studies, my colleagues and I noticed that cervical tumors that took up a lot of glucose prior to radiation treatment tended to be more resistant to radiation therapy than other tumors.