Sentences with phrase «of mouse lines»

Deletion, duplication, inversion, many configurations have been tested and validated by the generation of mouse lines carrying these mutations, and their transmission to the lineage.

Looking at 3,006 of these mouse lines they found that 67 had some degree of hearing loss.

The MMRRC is preserving and distributing a portion of these mouse lines obtained under NIH's Deltagen - Lexicon KO Mouse Line Procurement contracts with Deltagen, Inc.and Lexicon Genetics, Inc..

A comprehensive and secure set of services for the cryopreservation and recovery of mouse lines including importation, recovery, archiving, and distribution.

With such a rapid acceleration in the production of mouse lines that could be used to study a wide variety of phenomena, it's possible that we'll learn much more from our favourite mammalian model organisms in the near future.

Over 80 percent of the mouse lines assessed had a characteristic that provided a clue to what the missing gene's role might be.

The technical evaluation of projects may require the provision of additional data such as information on the genetic modification of your mutant mouse line if applicable (e.g. affected gene, MGI ID of the gene, type of mutation, ES - cell line used, genetic background (e.g. number of backcross generations), safety level, description of DNA modification, vector, remaining non-recipient DNA, donor organism), mutant phenotype (s), special housing or care requirements, current sanitary status, and intellectual property rights (who generated the mouse line, owner of the mouse line)

If a mouse mutant line was provided by selected applicants for a phenotyping project, sharing of the mouse line is also required and facilitated by the INFRAFRONTIER / EMMA repository.

Not exact matches

If you've used an Apple mouse (IDEO fashioned the company's first, in 1980), swept with a Procter & Gamble (PG) Swiffer (it collaborated on the hit), or even stood in line at an airport recently (the firm has worked with the Transportation Security Administration to make the process friendlier), you've felt the legacy of David Kelley.

With a click of your mouse you can add a new line with a new number or forward your calls.

The on - line companion directory ensures that the information remains current and gives you access to all the resources of this Directory and Yearbook with the click of your mouse.

Capsaicin additionally produced a significant deceleration of the development of prostate tumors created simply by those human cell lines grown in mouse models.

With one click of the mouse viewers can see opening lines, current lines, injury reports and team match ups.

Just Play Toys makes some fun toys for preschoolers including a great line of Minnie Mouse toys, toys from Doc McStuffins and much more!

Disney's mission statement is «To Make People Happy,» but many parents fear THE MOUSE, and think a more accurate statement might be «To Make People Wait In Lines In The Hot Sun And Spend Lots Of Money» or feel Grumpy Dwarf is an accurate representation of a parent's mood at the end of a day at The Magic KingdoOf Money» or feel Grumpy Dwarf is an accurate representation of a parent's mood at the end of a day at The Magic Kingdoof a parent's mood at the end of a day at The Magic Kingdoof a day at The Magic Kingdom.

Belly Bedaine — the Kangaroo carrying sweater Lil» Monkey Cheeks — the Mouse & Hatter carseat poncho Gentle Nest — anything from Omaiki's Lotus line Jack's Mama Creations — the tall sheepskin booties Cloth Diaper Kids — the Grovia zippered wetbag Calgary Cloth Diaper Depot — the Bummis Swimmi swim diaper Unicorn Baby — any of the Colibri snack bags Cozy Bums — the OKO Creations hemp nursing pads Carry Me Mommy — Lenny Lamb ring sling Baby Footprint — Joco glass reusable coffee cup

The kids LOVED the pop up booth at Just Play Toys which featured their great line of Minnie Mouse and Doc McStuffins toys!

The Weill Cornell researchers» process was more direct: Four transcription factors prompted adult mouse endothelial cells, which line the inside of blood vessels, to turn into HSCs.

In mice, norovirus infects rare cells in the lining of the gut called tuft cells.

One of the research lines that John, an investigator of the Howard Hughes Medical Institute (HHMI) and a professor at The Jackson Laboratory in Bar Harbor, Maine, currently has going is the development of a wireless sensor so tiny it can be implanted into the eye of a mouse.

Introducing human prostate cancer cell lines into mice, Wu and his colleagues saw a particular enzyme called MAOA activate a cascade of signals that made it easier for tumor cells to invade and grow in bone.

But mice with a working version of the gene suffered little to no damage to their gut - lining cells.

The researchers used two genetic lines of mice in the study to focus on AHR.

Their report, published May 10 in the journal Nature Communications, suggests that among more than a dozen different lines of mice developed around the world to mirror autism caused by mutations to the SHANK3 gene, Duke researchers are the first to create a mouse in which that gene has been completely eliminated.

About three - fourths of the stem cell lines were found to be unsuitable for research, and many if not all the lines were contaminated with mouse feeder cells.

Downstairs, the researchers maintained a colony of mice at the other end of the size spectrum: the Ames dwarf line, which Bartke had been studying since the»60s.

These effects endured not only throughout the animals» lives but were carried on to the next generation and along the same gender lines: The offspring of dual - parented pups turned in superior performances on tests of cognitive ability and social skills than mice raised by single parents.

Despite the presumed virulence of the strain — experiments with mouse lungs showed it produces 1000 times more bacteria in infected cells than do standard varieties — Valway says the number of TB cases that developed were kept in line with other typical outbreaks, which «shows that doing good contact investigations is important and preventative therapy works.»

In healthy mice, normal sperm line up at the center of a part of the testes known as the seminiferous tubule, ready for release (left, arrows).

Compared with unheated mice, the animals with the faux fever had twice as many white blood cells migrating out of the blood vessels and into the lymph tissue that lines the skin and gut, which is where they need to be to attack incoming pathogens.

The study involved laboratory cell lines of human leukemia and mouse models of the disease.

Studying mice with injuries to the lining of the stomach, the researchers blocked the animals» ability to call on stem cells for help in the stomach.

The research, conducted in cell lines and mouse models, explored enhancing the cancer - killing effects of PARP inhibitors not only in regard to AML but also triple - negative breast cancer.

The scientists then tested three new mTOR inhibitors currently under development (pp242, AZD8055 and INK128) in combination with the chemotherapies AraC, Etoposide and Cisplatin to see how they affected laboratory lines of leukemia cells and mouse models of the disease.

First she deprived juveniles of vision in one eye so that the corresponding brain cells failed to make connections; once the mice reached maturity, they were put in a water maze that required them to recognize a pattern of fine lines to find a floating platform.

In experiments conducted on human lung endothelial cells and in mice, the researchers showed that NS1 caused permeability of the endothelium, which lines the walls of blood and lymph vessels.

But when the researchers included features of the mouse paths — such as deviation from a straight line — in their training materials, computers were able to successfully pick out the liars 90 % to 95 % of the time, the researchers reported last month in PLOS ONE.

In testing on two mouse cell lines, the drug combination reduced the viability of cancer cells by about 50 percent when compared with everolimus alone, according to the findings.

Fortunately, an immunologist at Berkeley, David Raulet, had bred a line of mice incapable of expressing functional MHCI proteins.

The researchers also tested a Runx2 knock - down variant of a human multiple myeloma cell line and found that it produced significantly less tumor growth in immunodeficient mice than the original human multiple myeloma cells.

To speed the search, the team had engineered a line of mouse cells to test for G - CSF - like activity.

The increase in electricity — and thus the presumed sensitivity of the mouse to cocaine — lined up perfectly with the rate at which the mice ran around the track.

This take on Michelangelo's famous Sistine Chapel image symbolizes the link between human pain patients and the mouse model: The lab - designed SPR inhibitor (in green), shown within the active pocket of SPR itself (in gray with its atomic structure in colored lines), is the «bridge» between the two species.

Until 2009, Saitou's starting point had been cells taken from a live mouse epiblast — a cup - like collection of cells lining one end of the embryo that forms at the end of the first week of development, just before the PGCs emerge.

In a previous study, Professor Schmidt - Ott and his team discovered that it regulates the differentiation of epithelial cells — they line the cavities and surfaces of structures throughout the body — in the mouse embryo.

He has found that when a lab mouse misses its daily ration, B. theta consumes the globs of sugary mucus made every day by some cells in the intestinal lining.

In human donor cells and mouse experimental models, the researchers demonstrated that TSLP specifically targeted neutrophils — white blood cells that constitute the first line of defense against bacterial infections.

For Chen and Birsoy, the next step in this line of research is to test the effects of ATPIF1 suppression in mouse models of mitochondrial dysfunction.

Apart from patient testimonials and a few preliminary studies in tumor cell lines and in mice, critics say, there is no evidence of the safety or efficacy of the compound, popularly known as the «cancer pill» or «fosfo.»

Now, before you go imagining some chortling along the lines of one rakish Stuart Little (or was he a mouse?)