Each month through partnerships with researchers around the world, the MMRRC enhances critical research with a continuously expanding catalog
of mouse models of human disease.
OMC is a scientific and technological platform aimed at supporting R&D activities related to the validation and use
of mouse models of human disease.
During its Preparatory Phase, INFRAFRONTIER aimed at resolving the major issues required for implementing a sustainable INFRAFRONTIER Research Infrastructure for systemic phenotyping, archiving and distribution
of mouse models of human diseases:
Capacity building to meet the increasing demand of the biomedical research community for systemic phenotyping, archiving and distribution
of mouse models of human diseases.
Technical approaches
of mouse model of human diseases.
Not exact matches
Gene therapy delivered to a specific part
of the brain reverses symptoms
of depression in a
mouse model of the
disease — potentially laying the groundwork for a new approach to treating severe cases
of human depression in which drugs are ineffective.
These findings allowed researchers to create a chimera virus: a
mouse virus with a
human viral gene that can be used to test molecules that inhibit
human LANA protein in an animal
model of disease, treating not only
human herpes virus infection but also its associated cancers.
Researchers from Instituto de Medicina Molecular (iMM) Lisboa have created a chimera virus that allows the study
of molecules to treat cancers caused by
human herpes virus infection in
mice models of disease.
The behavioral tests used here
modeled one dimension
of the
disease — an inability to experience pleasure from normal activities — but not others, such as stress and anxiety, and probably tap into different brain mechanisms in
mice than in
humans, he says.
By directly manipulating a portion
of the prion protein - coding gene, Whitehead Institute researchers have created
mouse models of two neurodegenerative
diseases that are fatal in
humans.
We demonstrated that DENV serotype 2 (DENV2)-- specific
human monoclonal antibody (HMAb) 2D22 is therapeutic in a
mouse model of antibody - enhanced severe dengue
disease.
Even the new studies clashed somewhat: Unlike the UCSF study, the German research found no major differences between the overall microbiomes
of twins with and without MS. Finally,
mouse models of MS are not perfect mimics
of the
human disease, and
mouse immune systems aren't identical to people's.
The study involved laboratory cell lines
of human leukemia and
mouse models of the
disease.
The UT Southwestern group had previously used CRISPR - Cas9, the original gene - editing system, to correct the Duchenne defect in a
mouse model of the
disease and in
human cells.
This was observed in
human ovarian cancer cells grown in culture, and then in
mouse models of the
disease.
Desgrosellier said the team will follow up with
mouse models containing tumor fragments from patients to better reflect the diversity
of cell types present in
human disease.
Most animal studies
of the
disease are conducted with laboratory
mice that have been genetically engineered and bred to
model ALS, but for this research, investigators used rats with ALS because they more accurately portray the
disease's variable course in
humans.
«This research project is a prime example
of how
mouse models can help us to better understand cancer
diseases in
human beings,» says Sabine Harlander.
«The
mouse models don't recapitulate the
human disease,» said Ravi Basavappa
of the National Institutes
of Health, which gave Fine one
of its 12 Pioneer Awards for «unusually bold,» high - risk, and potentially high - impact research.
First, the researchers used
mice that had been genetically modified to produce excess amounts
of the
human version
of ß amyloid — a common Alzheimer's
disease model.
By studying how these genes cause defects in fly and
mouse models, we can improve our insights into the mechanisms related to
human disease,» said corresponding author and Dr. Hugo J. Bellen, professor
of neuroscience and molecular and
human genetics at Baylor College
of Medicine and an investigator at the Howard Hughes Medical Institute.
Mouse embryonic stem cells, reported in 1981 by Martin Evans, Matthew Kaufman, and Gail Martin, have allowed scientists to generate genetically customized strains
of mice that have revolutionized studies
of organismic development and immunity and have provided countless
models of human disease.
In a novel animal study design that mimicked
human clinical trials, researchers at University
of California, San Diego School
of Medicine report that long - term treatment using a small molecule drug that reduces activity
of the brain's stress circuitry significantly reduces Alzheimer's
disease (AD) neuropathology and prevents onset
of cognitive impairment in a
mouse model of the neurodegenerative condition.
She analyzes the comparative histopathology
of genetically altered
mice and
models of human diseases, including cancer, inflammatory disorders, and microbial infections.
First author Antonio Di Meco and colleagues used a triple transgenic (3xTg)
mouse model that displays an AD - like phenotype, including cognitive decline, and Aβ and tau neuropathology characteristic
of the
disease in
humans.
The researchers used
mouse models that mimic the
disease characteristics
of pulmonary hypertension and pulmonary fibrosis in
humans to study the effect
of triciribine, which inhibits production
of a protein called Akt1.
«We think that for the first time, we have a
mouse model of anorexia that closely resembles the conditions leading up to the
disease in
humans,» said study leader Lori Zeltser, PhD, associate professor
of pathology & cell biology and a researcher in the Naomi Berrie Diabetes Center.
Although genetically modified
mice have been used widely to
model neurodegenerative
diseases, they lack the typical neurodegeneration or overt neuronal loss seen in
human brains, says corresponding author Xiao - Jiang Li, MD, PhD, distinguished professor
of human genetics at Emory University School
of Medicine.
Grima used two
mouse models of Huntington's
disease: one with a
human version
of the mutant Huntingtin protein and another with an aggressive form
of the
disease that contains only the first portion
of the
mouse Huntingtin protein.
To study the still unknown pathogenesis
of the
disease, the researchers developed a
mouse model susceptible to the full range
of infection by the
human parasite.
His symptoms may come closer to mimicking the
human disease than most
mouse models of mental illness, because the gene involved has such a powerful effect.
They also provide new information to determine when the
mouse is an appropriate
model to study
human biology and
disease, and may help to explain some
of its limitations.
Using a
model of Parkinson's
disease in which the toxin MPTP, made famous in book «The Case
of the Frozen Addicts,» induces Parkinson's - like symptoms in
humans and
mice, Dr. Smeyne showed that
mice infected with H1N1, even long after the initial infection, had more severe Parkinson's symptoms than those who had not been infected with the flu.
The new study is based on the development
of mouse models manifesting the
disease that causes megalencephaly, spasticity and ataxia in
humans.
In his Ph.D. project, Dr. Henri Leinonen investigated functional abnormalities
of the retina using
mouse models of human central nervous system
diseases.
In
humans, α - synuclein would not necessarily turn out to be equally aggressive —
mouse models of neurodegenerative
diseases do not mimic
human disease very closely — but scientists are taking the possibility seriously.
These methods were used to test different attributes
of vision in three distinct genetically engineered
mouse models of human CNS
diseases.
The new Mount Sinai study reveals how loss
of a protein called Sirtuin1 (SIRT1) affects the ability
of blood stem cells to regenerate normally, at least in
mouse models of human disease.
The finding, by researchers at the University
of Illinois at Chicago College
of Medicine, was reported July 16 at the Alzheimer's Association International Conference in Copenhagen by Mary Jo LaDu, who in 2012 developed a transgenic
mouse that is now regarded as the best animal
model of the
human disease.
But Franklin and others suspect that in their zeal to clean up, facilities may have wiped out some
of the microbial complexity that makes
mice useful
models for
human disease.
Functional changes
of the retina were found in three
mouse models of human CNS
diseases whose phenotype, age
of onset and pathological mechanism clearly differ from each other.
The phosphorylation
of eIF2alpha, which decreases protein synthesis, was previously found at elevated levels in both
humans diagnosed with Alzheimer's and in Alzheimer's
Disease (AD)
model mice.
Thank you for airing Joseph Garner's views on the futility
of trying to cure
mouse «
models»
of human diseases (29...
To determine the effect
of gastric acid suppression on the progression
of chronic liver
disease, Schnabl's team looked at
mouse models that mimic alcoholic liver
disease, NAFLD and NASH in
humans.
Prof. Jean - Christophe Marine (VIB - KU Leuven) and others developed
mouse models recapitulating some
of the key histopathological features
of the
human disease.
«If the
mouse models are indicative
of human disease, the combination therapy can increase the proportion
of patients who respond to therapy without additional adverse side effects and can improve the quality
of life for cancer patients.»
«New MRI approach detects early liver tumors in
mouse model of human disease.»
However, Dr. Kissler's group discovered that reducing levels
of the RGS1 protein did not slow the progression
of the
disease in
mouse models, suggesting that it may not offer much potential for
human treatment.
In recent years, researchers have found that both
humans with Alzheimer's
Disease and AD
model mice have relatively high levels
of eIF2alpha phosphorylation.
He studies
mouse models of cancers and
human diseases using genetically engineered
mice.