Sentences with phrase «of mouse models of human diseases»

Capacity building to meet the increasing demand of the biomedical research community for systemic phenotyping, archiving and distribution of mouse models of human diseases.

During its Preparatory Phase, INFRAFRONTIER aimed at resolving the major issues required for implementing a sustainable INFRAFRONTIER Research Infrastructure for systemic phenotyping, archiving and distribution of mouse models of human diseases:

OMC is a scientific and technological platform aimed at supporting R&D activities related to the validation and use of mouse models of human disease.

Each month through partnerships with researchers around the world, the MMRRC enhances critical research with a continuously expanding catalog of mouse models of human disease.

Technical approaches of mouse model of human diseases.

Not exact matches

Gene therapy delivered to a specific part of the brain reverses symptoms of depression in a mouse model of the disease — potentially laying the groundwork for a new approach to treating severe cases of human depression in which drugs are ineffective.

These findings allowed researchers to create a chimera virus: a mouse virus with a human viral gene that can be used to test molecules that inhibit human LANA protein in an animal model of disease, treating not only human herpes virus infection but also its associated cancers.

Researchers from Instituto de Medicina Molecular (iMM) Lisboa have created a chimera virus that allows the study of molecules to treat cancers caused by human herpes virus infection in mice models of disease.

The behavioral tests used here modeled one dimension of the disease — an inability to experience pleasure from normal activities — but not others, such as stress and anxiety, and probably tap into different brain mechanisms in mice than in humans, he says.

By directly manipulating a portion of the prion protein - coding gene, Whitehead Institute researchers have created mouse models of two neurodegenerative diseases that are fatal in humans.

We demonstrated that DENV serotype 2 (DENV2)-- specific human monoclonal antibody (HMAb) 2D22 is therapeutic in a mouse model of antibody - enhanced severe dengue disease.

Even the new studies clashed somewhat: Unlike the UCSF study, the German research found no major differences between the overall microbiomes of twins with and without MS. Finally, mouse models of MS are not perfect mimics of the human disease, and mouse immune systems aren't identical to people's.

The study involved laboratory cell lines of human leukemia and mouse models of the disease.

The UT Southwestern group had previously used CRISPR - Cas9, the original gene - editing system, to correct the Duchenne defect in a mouse model of the disease and in human cells.

This was observed in human ovarian cancer cells grown in culture, and then in mouse models of the disease.

Desgrosellier said the team will follow up with mouse models containing tumor fragments from patients to better reflect the diversity of cell types present in human disease.

Most animal studies of the disease are conducted with laboratory mice that have been genetically engineered and bred to model ALS, but for this research, investigators used rats with ALS because they more accurately portray the disease's variable course in humans.

«This research project is a prime example of how mouse models can help us to better understand cancer diseases in human beings,» says Sabine Harlander.

«The mouse models don't recapitulate the human disease,» said Ravi Basavappa of the National Institutes of Health, which gave Fine one of its 12 Pioneer Awards for «unusually bold,» high - risk, and potentially high - impact research.

First, the researchers used mice that had been genetically modified to produce excess amounts of the human version of ß amyloid — a common Alzheimer's disease model.

By studying how these genes cause defects in fly and mouse models, we can improve our insights into the mechanisms related to human disease,» said corresponding author and Dr. Hugo J. Bellen, professor of neuroscience and molecular and human genetics at Baylor College of Medicine and an investigator at the Howard Hughes Medical Institute.

Mouse embryonic stem cells, reported in 1981 by Martin Evans, Matthew Kaufman, and Gail Martin, have allowed scientists to generate genetically customized strains of mice that have revolutionized studies of organismic development and immunity and have provided countless models of human disease.

In a novel animal study design that mimicked human clinical trials, researchers at University of California, San Diego School of Medicine report that long - term treatment using a small molecule drug that reduces activity of the brain's stress circuitry significantly reduces Alzheimer's disease (AD) neuropathology and prevents onset of cognitive impairment in a mouse model of the neurodegenerative condition.

She analyzes the comparative histopathology of genetically altered mice and models of human diseases, including cancer, inflammatory disorders, and microbial infections.

First author Antonio Di Meco and colleagues used a triple transgenic (3xTg) mouse model that displays an AD - like phenotype, including cognitive decline, and Aβ and tau neuropathology characteristic of the disease in humans.

The researchers used mouse models that mimic the disease characteristics of pulmonary hypertension and pulmonary fibrosis in humans to study the effect of triciribine, which inhibits production of a protein called Akt1.

«We think that for the first time, we have a mouse model of anorexia that closely resembles the conditions leading up to the disease in humans,» said study leader Lori Zeltser, PhD, associate professor of pathology & cell biology and a researcher in the Naomi Berrie Diabetes Center.

Although genetically modified mice have been used widely to model neurodegenerative diseases, they lack the typical neurodegeneration or overt neuronal loss seen in human brains, says corresponding author Xiao - Jiang Li, MD, PhD, distinguished professor of human genetics at Emory University School of Medicine.

Grima used two mouse models of Huntington's disease: one with a human version of the mutant Huntingtin protein and another with an aggressive form of the disease that contains only the first portion of the mouse Huntingtin protein.

To study the still unknown pathogenesis of the disease, the researchers developed a mouse model susceptible to the full range of infection by the human parasite.

His symptoms may come closer to mimicking the human disease than most mouse models of mental illness, because the gene involved has such a powerful effect.

They also provide new information to determine when the mouse is an appropriate model to study human biology and disease, and may help to explain some of its limitations.

Using a model of Parkinson's disease in which the toxin MPTP, made famous in book «The Case of the Frozen Addicts,» induces Parkinson's - like symptoms in humans and mice, Dr. Smeyne showed that mice infected with H1N1, even long after the initial infection, had more severe Parkinson's symptoms than those who had not been infected with the flu.

The new study is based on the development of mouse models manifesting the disease that causes megalencephaly, spasticity and ataxia in humans.

In his Ph.D. project, Dr. Henri Leinonen investigated functional abnormalities of the retina using mouse models of human central nervous system diseases.

In humans, α - synuclein would not necessarily turn out to be equally aggressive — mouse models of neurodegenerative diseases do not mimic human disease very closely — but scientists are taking the possibility seriously.

These methods were used to test different attributes of vision in three distinct genetically engineered mouse models of human CNS diseases.

The new Mount Sinai study reveals how loss of a protein called Sirtuin1 (SIRT1) affects the ability of blood stem cells to regenerate normally, at least in mouse models of human disease.

The finding, by researchers at the University of Illinois at Chicago College of Medicine, was reported July 16 at the Alzheimer's Association International Conference in Copenhagen by Mary Jo LaDu, who in 2012 developed a transgenic mouse that is now regarded as the best animal model of the human disease.

But Franklin and others suspect that in their zeal to clean up, facilities may have wiped out some of the microbial complexity that makes mice useful models for human disease.

Functional changes of the retina were found in three mouse models of human CNS diseases whose phenotype, age of onset and pathological mechanism clearly differ from each other.

The phosphorylation of eIF2alpha, which decreases protein synthesis, was previously found at elevated levels in both humans diagnosed with Alzheimer's and in Alzheimer's Disease (AD) model mice.

Thank you for airing Joseph Garner's views on the futility of trying to cure mouse «models» of human diseases (29...

To determine the effect of gastric acid suppression on the progression of chronic liver disease, Schnabl's team looked at mouse models that mimic alcoholic liver disease, NAFLD and NASH in humans.

Prof. Jean - Christophe Marine (VIB - KU Leuven) and others developed mouse models recapitulating some of the key histopathological features of the human disease.

«If the mouse models are indicative of human disease, the combination therapy can increase the proportion of patients who respond to therapy without additional adverse side effects and can improve the quality of life for cancer patients.»

«New MRI approach detects early liver tumors in mouse model of human disease.»

However, Dr. Kissler's group discovered that reducing levels of the RGS1 protein did not slow the progression of the disease in mouse models, suggesting that it may not offer much potential for human treatment.

In recent years, researchers have found that both humans with Alzheimer's Disease and AD model mice have relatively high levels of eIF2alpha phosphorylation.

He studies mouse models of cancers and human diseases using genetically engineered mice.