Sentences with phrase «of multiple antibodies»

Staining patterns are evaluated based on consistency between staining patterns of multiple antibodies against the same target and match to transcriptomics data.

Not exact matches

Earlier this month, the FDA approved two other treatments for multiple myeloma, including another kind of monoclonal antibody drug (the same class of drug that elotuzumab is in).

Breech Twins and higher order multiples Previous CS Pre-Eclampsia Placenta praevia Cervical incompetence Previous late stillbirth Previous premature birth Grand multiparty Age under 18 Age over 35 Smoking Drug use Severe mental health issue Epilepsy Type 1 diabetes Type 2 diabetes Gestational diabetes Asthma GBS positive Abnormal antibodies Transplant recipient Congenital heart disease Known foetal abnormality Immunosuppressive medication MS Physical disability Intellectual disability Hypothyroidism Hyperthyroidism Previous shoulder dystocia Previous 3rd or 4th degree tear Sickle Cell anaemia BMI under 18 or over 35 at conception Previous massive PPH APH in current pregnancy HIV / AIDS Hepatitis B or C Active TB IUGR Oligohydramnios Polyhydramnios Child previously removed from custody because of abuse Uterine abnormalities such as uterine septum or double uterus Previous uterine surgery for fibroids Chronic renal problems Hypertension Auto immune condition Previous stroke or blod clot Cancer Domestic violence or abusive home Prisoners Homeless women

(borrowed from Dr Kitty) Breech Twins and higher order multiples Previous CS Pre-Eclampsia Placenta praevia Cervical incompetence Previous late stillbirth Previous premature birth Grand multiparty Age under 18 Age over 35 Smoking Drug use Severe mental health issue Epilepsy Type 1 diabetes Type 2 diabetes Gestational diabetes Asthma GBS positive Abnormal antibodies Transplant recipient Congenital heart disease Known foetal abnormality Immunosuppressive medication MS Physical disability Intellectual disability Hypothyroidism Hyperthyroidism Previous shoulder dystocia Previous 3rd or 4th degree tear Sickle Cell anaemia BMI under 18 or over 35 at conception Previous massive PPH APH in current pregnancy HIV / AIDS Hepatitis B or C Active TB IUGR Oligohydramnios Polyhydramnios Child previously removed from custody because of abuse Uterine abnormalities such as uterine septum or double uterus Previous uterine surgery for fibroids Chronic renal problems Hypertension Auto immune condition Previous stroke or blod clot Cancer Domestic violence or abusive home Prisoners Homeless women

«In the case of multiple sclerosis, as a patient progresses through steps of the disease, their body generates novel antibodies or higher existing antibody titers against certain proteins, such as myelination proteins.

Our data demonstrate the feasibility of targeted gene disruption in multiple rat strains within 4 months time, paving the way to a humanized monoclonal antibody platform and additional human disease models.

Two of the antibodies in the MB - 003 cocktail target a related region of the Ebola virus glycoprotein, and thus are more susceptible to localized changes affecting multiple antibodies.

The most likely theory, they say, is that multiple tetanus toxoid vaccines may produce antibodies that respond to the combination of the capsular pathogen and its carrier.

Multiple myeloma is preceded by a blood disorder called monoclonal gammopathy of undetermined significance (MGUS) in which abnormal plasma cells produce many copies of an antibody protein.

The discovery of how a KwaZulu - Natal woman's body responded to her HIV infection by making potent antibodies (called broadly neutralizing antibodies, because they are able to kill multiple strains of HIV from across the world), was reported today by the CAPRISA consortium of AIDS researchers jointly with scientists from the United States.

A randomized phase III trial finding that a new monoclonal antibody, elotuzumab, added to standard therapy, extended the duration of remission for patients with relapsed multiple myeloma by about five months Findings from two phase III studies showing that children with Wilms tumor who have a specific chromosomal abnormality do better with a more intensive, augmented chemotherapy regimen

Current estimates are that only about five percent of AIDS patients can produce these potent antibodies to HIV, and only multiple years after infection.

Using multiple statistical approaches to study a long - term pediatric cohort in Nicaragua, we show that risk of severe dengue disease is highest within a narrow range of preexisting anti-DENV antibody titers.

In its first clinical trial, a breakthrough antibody therapy produced at least partial remissions in a third of patients with multiple myeloma who had exhausted multiple prior treatments, investigators at Dana - Farber Cancer Institute and other organizations report today online in the New England Journal of Medicine.

This «suggests that antibodies specific for this conserved region could provide protection against multiple toxin - mediated clostridium infections and points to a generalizable strategy for generating safe vaccine antigens for this class of toxins,» they concluded.

Brilliant Violet dye conjugated secondary antibodies from Jackson ImmunoResearch allow the addition of more colors to multiple labeling assays.

BV421 and BV480 are available conjugated to a range of secondary antibodies recommended for multiple labeling due to their minimal cross-reactivity.

«The quality of these naturally occurring human antibodies as biological drugs to treat the virus infection is remarkable, and we are doubly encouraged because they recognize multiple species of Ebola,» said immunologist James Crowe, Director of the Vanderbilt Vaccine Center.

In addition to neutralizing multiple Ebolavirus species, one of the antibodies also protected guinea pigs from a lethal challenge of virus.

The antibodies were then used to investigate whether rogue proteins existed in the brain tissue and spinal fluid of patients with multiple sclerosis.

Such vaccines, which would contain multiple AMA1 sequences in complex with RON2, might induce antibodies targeted to a range of genetically diverse malaria parasites.

The development of trispecific multivalent antibodies combine the best attributes of each into a single molecule capable of recognizing and neutralizing multiple viruses not recognized by the individual bnAbs.

The 5E5 antibody recognized multiple types of cancer cells, including leukemia, ovarian, breast, and pancreatic cancer cells, but not normal tissues.

A separate group of mice that also received CD8 T cells or antibodies specific to the virus were protected from this detrimental outcome, indicating the importance of inducing multiple arms of the immune response.

Scientists looking at the antiviral mechanisms of two previously identified human monoclonal antibodies have found they potently inhibit chikungunya virus (CHIKV) at multiple stages of infection.

Furthermore, these antibodies prevent CHIKV from both entering and exiting cells, whereas prior studies of neutralizing antibodies to CHIKV and multiple other classes of viruses have focused on the capacity to block viruses from entering a cell.

«An obstacle to creating an effective HIV vaccine is the difficulty of getting the immune system to generate antibodies against the sugar shield of multiple HIV strains,» said Lai - Xi Wang, a professor of chemistry and biochemistry at UMD.

But this week, researchers report that they've nabbed antibodies that disable multiple varieties of the virus.

More proof came when the researchers inhibited Udx1 with antibodies or drugs: the egg's membrane did not harden after fertilization, and multiple sperm entered, the team reports in this month's issue of Developmental Cell.

Unlike antibodies elicited by annual influenza vaccinations, most neutralizing antibodies induced by pandemic H1N1 infection were broadly cross-reactive against epitopes in the hemagglutinin (HA) stalk and head domain of multiple influenza strains.

They discovered that attachment is probably mediated by multiple weak interactions, which could potentially be blocked by a combination of drugs or antibodies.

We also demonstrate that multiple broadly neutralizing antibody lineages can be raised against HIV in the llama HCAb model and that, when combined as purified VHH, they provide enhanced breadth and potency of neutralization.

«As eliciting a highly diverse immune response may be favorable to providing protection against incredibly diverse HIV - 1 variants in global circulation,» the researchers conclude that their study «supports further investigations of the molecular and functional characteristics of the virus - antibody interplay in superinfected individuals, as superinfection may provide insight to the development of a diverse Nab response with multiple epitope specificities.»

Furthermore, there is very limited similarity to the human germ line V gene VH1 - 2 * 02 precursor of the VRC01 - like broadly neutralizing antibodies isolated from multiple patients.

Some of the anti-influenza antibodies generated by the technique recognized multiple strains of the virus and were able to neutralize its ability to infect cells.

A study led by St. Jude Children's Research Hospital identifies new path to a universal influenza vaccine emphasizing production of broadly specific antibodies that target multiple flu viruses

This is in contrast to the well - characterized VRC01 - like family of CD4 - binding site antibodies identified in multiple HIV - positive donors, which share both a heavy chain V gene precursor and unusual features at a DNA sequence level which could allow sequencing - based identification of other similar antibodies in distinct patients [53].

Researchers at Vanderbilt University Medical Center and the University of Texas Medical Branch in Galveston (UTMB) reported this week in the journal Cell that they have isolated human monoclonal antibodies from Ebola survivors that can neutralize multiple species of the virus.

These findings highlight the need to (a) induce multiple neutralizing antibody lineages for a protective antibody - based vaccine and (b) the potential need to use combinations of purified mAb in therapeutic or prophylactic settings.

Antibodies to the RNA Binding Protein Heterogeneous Nuclear Ribonucleoprotein A1 Colocalize to Stress Granules Resulting in Altered RNA and Protein Levels in a Model of Neurodegeneration in Multiple Sclerosis.

«Over the last 50 years, advances in antibody technology have delivered radical new treatments for a wide range of common diseases including rheumatoid arthritis, multiple sclerosis and some forms of cancer.

Dr. Polonis» lab has focused for many years on functional antibodies elicited by natural infection and by vaccination, utilizing samples from multiple natural history cohorts and vaccine studies; her lab is currently performing an extensive analysis of pseudovirus neutralizing antibodies in the large RV144 follow - on trial, RV306.

Cancers of the breast, prostate, colorectal system, liver and kidney as well as multiple myeloma, a cancer of the plasma cells that make antibodies to fight viruses and bacteria, strike earlier, deadlier and more often in some racial and ethnic groups, the National Cancer Institute has shown.

The investigators found that the immunized monkeys mounted antibody responses against diverse strains of HIV and the monkeys also mounted cellular immune responses to multiple regions of the virus.

iTeos and Adimab LLC are collaborating on the discovery, development and commercialization of multiple, antibody - based therapeutic programs, with Adimab using its antibody discovery and optimization platform to identify fully human therapeutic antibodies against targets selected by iTeos.

One theory is, because cows have multiple stomachs with lots of bacteria, they need extra-powerful antibodies to protect them from infection.

Myeloma — also referred to as multiple myeloma or plasma cell myeloma — is a cancer that originates in plasma cells, a type of white blood cell that makes antibodies.

Co-transfection of 293T cells with NL4 - 3 env plasmid yields an HIV - 1 pseudotype virus that is R5 - tropic and susceptible to neutralization by multiple antibodies.

As the number of multiple myeloma cells increases, more antibodies are made.

One secondary outcome will be immunogenicity, meaning monitoring subjects for any emergence of antibodies against the infused therapeutic antibodies themselves; additionally, «Multiple clinical and exploratory biomarkers will be assessed» in the Phase Ib trial.