Sentences with phrase «of multiple biomarkers»

The framework of allostasis and allostatic load is supported in that examination of multiple biomarkers working together in concert was of value in understanding mental health problems concurrently and longitudinally.

Joint analysis of multiple biomarkers for identifying type 2 diabetes in middle - aged and older Chinese: a cross-sectional study

The goal was to determine the ability of multiple biomarkers to identify and assess, and hopefully correlate to, the degree of heart disease in cats.

The assessment of multiple biomarkers with the use of robust and well - standardized assays, detailed diet assessment, and adjustment for principal risk factors all increased the validity of our results.

They say that the system can be constructed with more than five different aptamers, allowing detection of multiple biomarkers at once.

Hydrogel particles barcoded with unique fluorescent signatures enable detection of multiple biomarkers simultaneously.

Not exact matches

While we are unaware of any prior studies relating As biomarker concentrations to rice intake among infants, associations have been observed in pregnant women in our cohort, 19 children in the National Health and Nutrition Examination Survey, 16,18 and multiple studies of adults.11 - 15

«It can handle multiple biomarker technologies simultaneously, such as complex flow cytometry, next - generation sequencing, immunosequencing, epigenetic profiling, and other types of asssys measuring biological variation as well,» says Marshall.

«Using innovative data normalization and gene selection approaches, we combined the statistical power of multiple genomic studies and masked their variability and batch effects to identify robust early diagnostic biomarkers of pancreatic cancer,» said first author Manoj Bhasin, PhD, Co-Director of BIDMC's Genomics, Proteomics, Bioinformatics and Systems Biology Center and Assistant Professor of Medicine at HMS.

This will result in development of the first of its kind biomarker that gauges pancreatic cancer alterations from multiple genomic angles for making highly accurate diagnoses,» added Bhasin.

Our panelists will discuss how the ability to analyze multiple protein biomarkers is beginning to address some of these challenges, providing potentially important new insights into neurological disorders.

Dr. Quintana's research is focused on the regulation of the adaptive and innate immune response and the identification of biomarkers for multiple sclerosis (MS) and other immune - mediated diseases.

Additionally, M. Sykora et al. recently reported decreases in the autonomous system's measure of baroreflex sensitivity (BRS) as an independent predictor for post-stroke infections (4), and both the BRS and serum AChE activity correlated with multiple inflammatory biomarkers.

Participants who were vitamin D deficient were more likely to have high levels of these biomarkers, which are linked to cardiovascular disease and inflammatory conditions such as multiple sclerosis and rheumatoid arthritis.

«Our group, which includes more than 180 myeloma researchers worldwide, has updated the definition of multiple myeloma for diagnostic purposes to include validated biomarkers in addition to the current clinical symptoms used for diagnosis which include, elevated blood calcium levels, kidney failure, anemia and bone lesions,» said lead author S. Vincent Rajkumar, M.D. a hematologist at Mayo Clinic.

Lower blood levels of a biomarker called brain - derived neurotrophic factor (BDNF) have been associated with depression in multiple studies, mainly in non-pregnant adults.

Policymaking committees should consider giving less weight to food industry - funded studies, and include mechanistic and animal studies as well as studies appraising the effect of added sugars on multiple CHD biomarkers and disease development,» the article concludes.

UNISI provides expertise in the measurement of cell signalling proteins, such as cytokines, chemokines and inflammatory biomarkers in multiple samples (including serum, plasma and tissue culture supernatants), using a multiplex suspension array system or a flow cytometric bead assay.

In addition, results from a recently developed biomarker assay that was designed to measure levels of SMN protein in the cerebral spinal fluid (CSF), showed time - and dose - dependent increases in SMN protein levels in SMA children treated with ISIS - SMNRx from both single - and multiple - dose studies.

A recent study reported that two oxysterol species, 15HC and 15KC, were increased more than three-fold in the blood of multiple sclerosis patients, suggesting a potential use for these oxysterols as diagnostic biomarkers.

The research ideas you develop at the workshop should: • Lead to the significant advancement of our understanding of sensor technologies suitable for liquid biopsy • Consider the practical challenges of low volume liquid usually taken for analysis and the inconsistency of sample preparation across point of care sites • Prioritise biomarkers with high specificity for cancer or even for multiple cancer types, including markers specific to cancers that will become aggressive as opposed to non-lethal disease

The platform can analyze multiple biomarkers quickly and efficiently, as demonstrated by the fact that a total of 458 plasma samples were analyzed in triplicate, with 23 ELISA analyses per sample - replicate, in a single experiment.

One secondary outcome will be immunogenicity, meaning monitoring subjects for any emergence of antibodies against the infused therapeutic antibodies themselves; additionally, «Multiple clinical and exploratory biomarkers will be assessed» in the Phase Ib trial.

Dr. Katerina Akassoglou says a biomarker for multiple sclerosis could transform the diagnosis and care of MS, while also aiding in the development of new therapies and improving clinical trials.

Identifying a reliable biomarker may accelerate diagnosis of multiple sclerosis (MS) and lead to early management of the disease.

UNISI will provide expertise in the measurement of cell signalling proteins, such as cytokines, chemokines and inflammatory biomarkers in multiple samples (including serum, plasma and tissue culture supernatants), using a multiplex suspension array system or a Cytometric bead assay.

Multiple biomarkers, such as cytokines, chemokines and growth factors will be detected using one of the available multiplex system to test up to 46 murine and 53 human analysts.

The consensus conference even showed signs of being holistic, emphasizing that a comprehensive evaluation for heart disease risk should be made up of «multiple biomarkers including total and HDL cholesterol, blood pressure, body fatness, glucose tolerance, and inflammatory markers.»

First, depression has been linked to multiple biological abnormalities, including vascular pathologic changes, autonomic function changes, hypercoagulability, and hypothalamic - pituitary - adrenal axis hyperactivity.10 Evidence shows that depression in adulthood is linked to elevated risk of developing cardiovascular disease, diabetes, and dementia in later life.11 Second, inflammation contributes to atherosclerosis, insulin resistance, and neurodegeneration.12 - 14 Evidence shows that elevation in inflammation biomarkers, such as C - reactive protein (CRP), in adulthood predicts the development of cardiovascular disease, diabetes, and dementia in later life.15 - 17 Third, metabolic abnormalities such as obesity, dyslipidemia, glucose intolerance, hypertension, and cardiorespiratory fitness contribute to vascular lesions and hormonal imbalance.

The present study is informed by the theory of allostatic load to examine how multiple stress responsive biomarkers are related to mental health outcomes.