«Our view is that strandings are likely caused by a complex combination
of multiple environmental factors, so we want to include the widest possible range of possible parameters in the follow - up study.»
Not exact matches
Post-partum depression poses substantial adverse consequences for mothers and their infants via
multiple direct biological (i.e., medication exposure, maternal genetic
factors) and
environmental (i.e., life with a depressed mother) mechanisms.8, 9 From the earliest newborn period, infants are very sensitive to the emotional states
of their mothers and other caregivers.10, 11 Maternal mood and behaviour appear to compromise infant social, emotional and cognitive functioning.11 - 15 As children grow, the impact
of maternal mental illness appears as cognitive compromise, insecure attachment and behavioural difficulties during the preschool and school periods.6,16 - 19
What has become clear from their research is that there is no single genetic pathway to controlling HIV; there likely are
multiple routes, each with their own combination
of genetic and
environmental factors.
Multiple research projects have shown that about half
of the variation in people's body mass index can be attributed to genetic
factors, while the rest is due to
environmental factors, including diet and exercise.
Dysevolution is what Lieberman calls «the deleterious feedback loop that occurs over
multiple generations when we don't treat the causes
of a mismatch disease but instead pass on whatever
environmental factors cause the disease, keeping the disease prevalent and sometimes making it worse.»
Although prior twin studies had hinted that nonheritable
factors contribute to some autoimmune disorders, such as
multiple sclerosis, the recent analysis was one
of the first to quantify genetic and
environmental effects on the general immune system.
And even if such a demand existed, there was no evidence that genetic counseling could help patients with psychiatric disorders, which — like most
of the more common diseases — are caused by a complex interplay
of multiple genes and variants as well as
environmental factors.
Hereditary predisposition to cancer is sometimes due to a single high - risk genetic change, like a mutation in the BRCA1 or BRCA2 genes for breast cancer, but most
of the time, the disease is the result
of multiple gene variants that add up,
environmental risk
factors, and a big element
of chance.
One difficulty in studying the genetics
of common mental illnesses is that they are generally caused by
environmental factors in combination with
multiple gene variants, any one
of which usually could not by itself cause disease.
«Yes, there is a set
of diseases that occur more frequently in blacks, but they're complex diseases, involving
multiple environmental factors and
multiple genes too.
«Crohn's disease is a complex disorder with
multiple genes and
environmental factors involved, which disproportionally affects individuals
of Ashkenazi Jewish ancestry,» explained lead researcher Inga Peter, Professor
of Genetics and Genomic Sciences at the Icahn School
of Medicine at Mount Sinai in New York City.
There are likely
multiple factors contributing to these deaths: other toxins in this species
of mushroom, the genetics
of the victims, contaminated food and other
environmental factors.
But he agrees that the field needs to examine how
multiple environmental factors interact and what that means for the future
of phytoplankton.
Multiple risk
factors have been associated with the development
of gastric intestinal metaplasia interplay, including Helicobacter pylori infection and associated genomics, host genetic
factors,
environmental milieu, rheumatologic disorders, diet, and intestinal microbiota.
Phenotypic complexity: integrated responses
of life history characters to
multiple environmental factors.
GENIC has completed (or has ongoing) a series
of studies to examine the interaction between
environmental risk
factors and susceptibility genes for non-Hodgkin lymphoma, melanoma, and
multiple myeloma, as well as breast, ovarian, and prostate cancers.
Common complex diseases are caused by
multiple genetic and
environmental factors, many
of which remain unknown.
Common complex disorders, such as coronary artery disease, develop as a result
of multiple genetic and
environmental factors.
It is believed that T1D results from complex interactions between
multiple genes,
environmental factors and the immune system, and the autoimmune aspects may begin many years before the clinical manifestation
of T1D.
This more dynamic approach allowed the researchers to evaluate the simultaneous effects
of multiple factors —
environmental, individual, genetic and structural — on network dynamics.
Odds ratios (OR) and 95 % confidence intervals (CI) were estimated with consideration
of multiple established reproductive and
environmental risk
factors for breast cancer.
They reflect an overall impact
of multiple causative
factors similar to those
of other developing countries where rice is not a major staple.8 Various deficiencies including zinc, vitamin C and D, folate, riboflavin, selenium and calcium occur in the context
of poverty,
environmental degradation, lack
of public health systems and sanitation, lack
of proper education and social disparity.
The diagnosis
of delayed reaction may be difficult because when the child returns home,
multiple environmental factors (infections, dietary
factors, emotional, casual contacts, sports - related physical activity) may impinge diagnostic interpretation.
Organizations such as The
Environmental Working Group and Institute for Responsible Technology are leading the way with research that shows the serious health impacts on the body from the impact
of genetically modified (GM) foods There are now
multiple animal studies that link GMO's with damage to the GUT, with immune disregulation, inflammation, and an increase in allergies or
factors that trigger autoimmune disease.
There are
multiple environmental factors such as caloric intake, level
of exercise, and weather that can affect the severity
of clinical signs and phenotypic expression (radiographic changes).
While it is true that canine hip dysplasia can be genetic in origin, it should be noted that
multiple environmental factors can play a role in the expression
of this particular trait.
«Many other important impacts
of climate change are difficult to quantify for a given change in global average temperature, in part because temperature is not the only driver
of change for some impacts;
multiple environmental and other human
factors come into play.»
(B) Changes in NPP in recent decades that resulted from
multiple environmental factors including climate, leaf area index (LAI), fraction
of photosynthetically active radiation (fPAR), and CO2, and the relative contribution rate (%)
of each
factor during the study period.
The success
of new cities depends on
multiple factors - geographical, economic, political, social, and now technological and
environmental - that planners must consider.
«Whereas if it relies on
multiple environmental conditions — like sunlight intensity, wind speed, precipitation — all
of these
factors could create a more stable power source with a higher power output.»
Associations between each
of the baseline residential -
environmental factors and five year survival were examined by
multiple logistic regression analysis.
In addition, a host
of environmental factors, such as chaotic living conditions, may interfere with the developing attachment relationship, particularly when intervening with families from high - risk populations who face
multiple personal and
environmental challenges.
Longitudinal research assessing
multiple domains
of risk
factor (personal, relational,
environmental) across the lifespan
of partners and their relationships is both needed and strongly encouraged.
However, in natural experiments,
multiple environmental factors tend to change simultaneously (e.g. mortality, morbidity, resource scarcity and distribution
of kin), making it difficult to isolate causal relationships, or describe the underlying psychological mechanisms.
Additionally, investigating interactions
of multiple genes and
environmental factors may provide further insight into the underlying neurobiological mechanisms.
Considering the complexity
of mental illnesses etiology, which involves
multiple interacting genetic,
environmental and biological
factors; large effect sizes are unlikely to be detected; therefore the magnitude
of the associations described in this community - based study are noteworthy and possibly indicative
of clinical relevance.
Within these trajectories, certain subgroups
of children are more at risk due to exposure to
multiple, cumulative, and prolonged
environmental or genetic risk
factors, such as poor attachment, maternal depression, and poverty.