In recent years, atypical protein kinase C signaling has been found in the tissue invasion and metastasis
of multiple tumors.
He and his co-investigators analyzed 66 ultrasound images of tumors (32 pictures of a single tumor and 34
of multiple tumors) inside a plastic model of a breast to determine the augmented - reality system's accuracy of measuring tumor volume.
Spread to other parts of the body (metastasis) is extremely rare but there is a syndrome
of multiple tumors called lipomatosis.
Not exact matches
Multiple myeloma causes
tumors to grow in the bone marrow, preventing the production
of normal blood cells.
In December, Pope Francis announced that Mother Teresa would be declared a saint after recognizing a second miracle attributed to her: the healing
of a Brazilian man with
multiple brain
tumors after loved ones prayed to her.
Given the results
of a a new study reported in the British medical journal, The Lancet4 that children and young adults scanned
multiple times by CT have a small increased risk
of leukemia and brain
tumors in the decade following their first scan, parents should make sure a CT scan is really necessary in treatment
of their child after head injury.
Analyzing a database
of nearly 800
multiple myeloma patient samples, they discovered that 162 patients with low ADAR1 levels in their
tumor cells survived significantly longer over a three - year period compared to 159 patients with high ADAR1 levels.
«Several major advances in recent years have been good news for
multiple myeloma patients, but those new drugs only target terminally differentiated cancer cells and thus can only reduce the bulk
of the
tumor,» said Jamieson, who is also deputy director
of the Sanford Stem Cell Clinical Center, director
of the CIRM Alpha Stem Cell Clinic at UC San Diego and director
of stem cell research at Moores Cancer Center at UC San Diego Health.
«Most cancer patients are actually at risk
of having their
tumor spread to
multiple sites,» Dr. MassaguĂ© notes.
An international team
of researchers has identified eight additional types
of cancer linked to excess weight and obesity: stomach, liver, gall bladder, pancreas, ovary, meningioma (a type
of brain
tumor), thyroid cancer and the blood cancer
multiple myeloma.
This gene is known to be highly active in
multiple myeloma and many other cancers, raising the possibility that strategies to shut it down could be effective against a variety
of tumors.
The researchers also tested a Runx2 knock - down variant
of a human
multiple myeloma cell line and found that it produced significantly less
tumor growth in immunodeficient mice than the original human
multiple myeloma cells.
In other words, regardless
of surgery timing, patients who require higher risk procedures, such as a major liver resection due to the presence
of larger or
multiple metastatic
tumors or high - risk colorectal resections, have poorer outcomes than those who underwent more minor surgery.
«Thanks to a deeper understanding
of cancer biology, we have a potential new targeted therapy for
multiple myeloma, and can better tailor treatment for kids with Wilms
tumor.
A randomized phase III trial finding that a new monoclonal antibody, elotuzumab, added to standard therapy, extended the duration
of remission for patients with relapsed
multiple myeloma by about five months Findings from two phase III studies showing that children with Wilms
tumor who have a specific chromosomal abnormality do better with a more intensive, augmented chemotherapy regimen
Multiple myeloma is a cancer
of plasma cells in the blood that causes
tumor growths in bone marrow.
Together they are being used to peer into the microenvironment
of tumors and other tissues while learning about the co-registration
of multiple lines
of imaging data.
One miRNA can target
multiple genes, but their expression is often hijacked by cancer cells and disrupts
multiple cancer - causing or
tumor - suppressing pathways,» says Shuk - Mei Ho, PhD, director
of the CCC and Jacob G. Schmidlapp Chair
of Environmental Health and professor at the University
of Cincinnati (UC) College
of Medicine.
The Cancer Vaccine Collaborative is working on treatments that target
multiple cancer antigens, which should trigger a more aggressive immune response and increase the odds
of defeating
tumors.
If metastatic cancers are most often made up
of cells with different genetic drivers, perhaps researchers should be targeting the primary
tumor with
multiple drugs to contain the cancer.
In this latest study, researchers were able to demonstrate the ability
of the nanosensor to illuminate
tumor tissue in
multiple mouse models.
The researchers then compared
tumor cells isolated from
multiple different breast cancer patients and found that cells expressing lower amounts
of Numb - 1 and -2 were more resistant to the chemotherapy agent cisplatin.
«These
tumors are genetically very complex, and we demonstrated this by showing just the sheer volume
of copy number changes, and that there are
multiple clones in a single metastases
tumor, and changes in metabolism that reflects the
tumor's ability to adapt.»
«The treatment
of multiple myeloma has improved significantly in recent years with the introduction of therapies such as proteasome inhibitors [which interfere with tumor cells» protein - disposal system] and potent immuno - modulatory agents,» said the paper's senior author and lead investigator, Paul Richardson, MD, clinical program leader and director of clinical research at Dana - Farber's Jerome Lipper Multiple Myeloma Center, and the R.J. Corman professor at Harvard Medical
multiple myeloma has improved significantly in recent years with the introduction
of therapies such as proteasome inhibitors [which interfere with
tumor cells» protein - disposal system] and potent immuno - modulatory agents,» said the paper's senior author and lead investigator, Paul Richardson, MD, clinical program leader and director
of clinical research at Dana - Farber's Jerome Lipper
Multiple Myeloma Center, and the R.J. Corman professor at Harvard Medical
Multiple Myeloma Center, and the R.J. Corman professor at Harvard Medical School.
The disease itself, with its
multiple tumors, suggests the handiwork
of such a gene gone awry.
To illuminate the process, the Yale team sequenced normal, primary, and metastatic
tumor tissue from
multiple individuals, including subjects with a range
of cancer types.
Though vestibular schwannomas affecting both sides are the hallmark
of neurofibromatosis type 2 (NF2), a genetic disorder causing
tumors to grow at
multiple sites throughout a person's life, vestibular schwannomas may also occur sporadically, and on one side only.
The resulting «map»
of gene - drug interactions allowed the researchers to accurately predict the responses
of multiple human cancer cell lines to different chemotherapy agents based on the cell lines» genetic profiles and also revealed new genetic factors that appear to determine the response
of breast and ovarian
tumor cells to common classes
of chemotherapy treatment.
We've got the genetic blueprint
of how to attack these
tumors, but there are
multiple obstacles that prevent implementation
of a genomics - driven personalized medicine.»
Both Tsigelny and Kurzrock agreed that this finding is an excellent example
of the power
of collaboration between SDSC and the Moores Cancer Center, and that such modeling needed to be studied across
tumors and with
multiple different genes involved in cancer.
However, resistance almost always develops because
tumors harbor
multiple genomic defects capable
of driving the disease after a targeted drug knocks down one driver.
In this case, the patient was able to go home the day after the successful removal
of multiple brain
tumors.»
That is, they contained
multiple populations
of cells, including the so - called JARID1B cells, which their research suggested was responsible for allowing
tumors to survive drug therapy.
HM - SNS allows researchers to sequence the genomes
of single
tumor cells and study
multiple cells simultaneously, both lowering the cost and boosting data analysis for such studies.
«Having these personalized laboratory models, which we can make in a matter
of weeks, will let us test
multiple different drugs on the
tumor and help us bring precision medicine to individuals with bladder cancer.»
Researchers from Uppsala University, Sweden, and the Broad Institute, USA, have identified both similarities and differences between a single
tumor type in
multiple dogs breeds; a finding they believe parallels the situation in the cancer
of human patients.
Moreover, approximately 30 %
of follicular lymphoma patients lose also a portion
of chromosome 6, affecting
multiple genes involved in suppressing the emergence
of a
tumor.
BETs have been fast - tracked into clinical trials and have shown impressive slowing
of tumor growth in
multiple cancer types.
A proteomic analysis
of the
tumors also identified
multiple protein targets that have the potential to respond to drugs.
However, about 10 percent
of them are common across
multiple cancers, suggesting that a relatively small number
of therapies targeting these core dependencies might each hold promise for combatting several
tumors.
«The current study investigated the impact
of dietary sugar on mammary gland
tumor development in
multiple mouse models, along with mechanisms that may be involved,» said co-author Lorenzo Cohen, Ph.D., professor
of Palliative, Rehabilitation, and Integrative Medicine.
«Our results are the first to provide insight into ways
of targeting
multiple brain metastatic deposits with stem - cell - loaded oncolytic viruses that specifically kill dividing
tumor cells.»
It is generally believed that a series
of mutations in
multiple genes are needed for cancer cells to become metastatic; however, recent cancer stem cell theory, which still remains as a hypothesis, predicts that metastatic
tumor cells are, by definition, cancer stem cells and that these cells may exist in
tumor mass even at an early stage.
After first verifying that stem cells injected to the brain would travel to
multiple metastatic sites and not to
tumor - free areas in their model, the team injected stem cells loaded with oHSV into the carotid artery
of metastasis - bearing mice..
The Ludwig Center at the University
of Chicago --- under the direction
of Ralph Weichselbaum, MD, the Daniel K. Ludwig Professor and Chair
of the Department
of Radiation and Cellular Oncology, and Geoffrey Greene, PhD, the Daniel K. Ludwig Professor in the Ben May Cancer Research Institute at the University
of Chicago — will focus on metastasis, the process by which cancer cells migrate from a primary
tumor to
multiple distant sites.
Bradner and Mitsiades had reported in Cell in 2011 that the inhibitor blocks the Myc cancer gene and thereby slows the growth
of multiple myeloma
tumors in mice.
We use
multiple mouse models combined with in vitro approaches to address the pleiotropic functions
of these cytokines which affect both the epithelial cancer cells and the inflammatory infiltrate within
tumors.
Cas9 - expressing mice can dramatically accelerate our understanding
of pathological processes that involve
multiple genes or mutations, like
tumor development.
Career Goals: I plan to pursue a career in scientific research focused in NKT cells which assist in prevention
of autoimmune diseases such as diabetes,
multiple sclerosis and
tumors.
Drew Pardoll, Glenn Dranoff, Elizabeth Jaffee, Hyam Levitsky, and colleagues conduct preclinical studies showing that a vaccine composed
of tumor cells irradiated and genetically modified to produce immune system growth factor GM - CSF (granulocyte - macrophage colony - stimulating factor)-- which would become known as the therapeutic cancer vaccine GVAX — could induce potent, specific, and long - lasting anti-
tumor immunity in
multiple mouse
tumor models.