Sentences with phrase «of multiple tumors»

Spread to other parts of the body (metastasis) is extremely rare but there is a syndrome of multiple tumors called lipomatosis.

He and his co-investigators analyzed 66 ultrasound images of tumors (32 pictures of a single tumor and 34 of multiple tumors) inside a plastic model of a breast to determine the augmented - reality system's accuracy of measuring tumor volume.

In recent years, atypical protein kinase C signaling has been found in the tissue invasion and metastasis of multiple tumors.

Not exact matches

Multiple myeloma causes tumors to grow in the bone marrow, preventing the production of normal blood cells.

In December, Pope Francis announced that Mother Teresa would be declared a saint after recognizing a second miracle attributed to her: the healing of a Brazilian man with multiple brain tumors after loved ones prayed to her.

Given the results of a a new study reported in the British medical journal, The Lancet4 that children and young adults scanned multiple times by CT have a small increased risk of leukemia and brain tumors in the decade following their first scan, parents should make sure a CT scan is really necessary in treatment of their child after head injury.

Analyzing a database of nearly 800 multiple myeloma patient samples, they discovered that 162 patients with low ADAR1 levels in their tumor cells survived significantly longer over a three - year period compared to 159 patients with high ADAR1 levels.

«Several major advances in recent years have been good news for multiple myeloma patients, but those new drugs only target terminally differentiated cancer cells and thus can only reduce the bulk of the tumor,» said Jamieson, who is also deputy director of the Sanford Stem Cell Clinical Center, director of the CIRM Alpha Stem Cell Clinic at UC San Diego and director of stem cell research at Moores Cancer Center at UC San Diego Health.

«Most cancer patients are actually at risk of having their tumor spread to multiple sites,» Dr. Massagué notes.

An international team of researchers has identified eight additional types of cancer linked to excess weight and obesity: stomach, liver, gall bladder, pancreas, ovary, meningioma (a type of brain tumor), thyroid cancer and the blood cancer multiple myeloma.

This gene is known to be highly active in multiple myeloma and many other cancers, raising the possibility that strategies to shut it down could be effective against a variety of tumors.

The researchers also tested a Runx2 knock - down variant of a human multiple myeloma cell line and found that it produced significantly less tumor growth in immunodeficient mice than the original human multiple myeloma cells.

In other words, regardless of surgery timing, patients who require higher risk procedures, such as a major liver resection due to the presence of larger or multiple metastatic tumors or high - risk colorectal resections, have poorer outcomes than those who underwent more minor surgery.

«Thanks to a deeper understanding of cancer biology, we have a potential new targeted therapy for multiple myeloma, and can better tailor treatment for kids with Wilms tumor.

A randomized phase III trial finding that a new monoclonal antibody, elotuzumab, added to standard therapy, extended the duration of remission for patients with relapsed multiple myeloma by about five months Findings from two phase III studies showing that children with Wilms tumor who have a specific chromosomal abnormality do better with a more intensive, augmented chemotherapy regimen

Multiple myeloma is a cancer of plasma cells in the blood that causes tumor growths in bone marrow.

Together they are being used to peer into the microenvironment of tumors and other tissues while learning about the co-registration of multiple lines of imaging data.

One miRNA can target multiple genes, but their expression is often hijacked by cancer cells and disrupts multiple cancer - causing or tumor - suppressing pathways,» says Shuk - Mei Ho, PhD, director of the CCC and Jacob G. Schmidlapp Chair of Environmental Health and professor at the University of Cincinnati (UC) College of Medicine.

The Cancer Vaccine Collaborative is working on treatments that target multiple cancer antigens, which should trigger a more aggressive immune response and increase the odds of defeating tumors.

If metastatic cancers are most often made up of cells with different genetic drivers, perhaps researchers should be targeting the primary tumor with multiple drugs to contain the cancer.

In this latest study, researchers were able to demonstrate the ability of the nanosensor to illuminate tumor tissue in multiple mouse models.

The researchers then compared tumor cells isolated from multiple different breast cancer patients and found that cells expressing lower amounts of Numb - 1 and -2 were more resistant to the chemotherapy agent cisplatin.

«These tumors are genetically very complex, and we demonstrated this by showing just the sheer volume of copy number changes, and that there are multiple clones in a single metastases tumor, and changes in metabolism that reflects the tumor's ability to adapt.»

«The treatment of multiple myeloma has improved significantly in recent years with the introduction of therapies such as proteasome inhibitors [which interfere with tumor cells» protein - disposal system] and potent immuno - modulatory agents,» said the paper's senior author and lead investigator, Paul Richardson, MD, clinical program leader and director of clinical research at Dana - Farber's Jerome Lipper Multiple Myeloma Center, and the R.J. Corman professor at Harvard Medicalmultiple myeloma has improved significantly in recent years with the introduction of therapies such as proteasome inhibitors [which interfere with tumor cells» protein - disposal system] and potent immuno - modulatory agents,» said the paper's senior author and lead investigator, Paul Richardson, MD, clinical program leader and director of clinical research at Dana - Farber's Jerome Lipper Multiple Myeloma Center, and the R.J. Corman professor at Harvard MedicalMultiple Myeloma Center, and the R.J. Corman professor at Harvard Medical School.

The disease itself, with its multiple tumors, suggests the handiwork of such a gene gone awry.

To illuminate the process, the Yale team sequenced normal, primary, and metastatic tumor tissue from multiple individuals, including subjects with a range of cancer types.

Though vestibular schwannomas affecting both sides are the hallmark of neurofibromatosis type 2 (NF2), a genetic disorder causing tumors to grow at multiple sites throughout a person's life, vestibular schwannomas may also occur sporadically, and on one side only.

The resulting «map» of gene - drug interactions allowed the researchers to accurately predict the responses of multiple human cancer cell lines to different chemotherapy agents based on the cell lines» genetic profiles and also revealed new genetic factors that appear to determine the response of breast and ovarian tumor cells to common classes of chemotherapy treatment.

We've got the genetic blueprint of how to attack these tumors, but there are multiple obstacles that prevent implementation of a genomics - driven personalized medicine.»

Both Tsigelny and Kurzrock agreed that this finding is an excellent example of the power of collaboration between SDSC and the Moores Cancer Center, and that such modeling needed to be studied across tumors and with multiple different genes involved in cancer.

However, resistance almost always develops because tumors harbor multiple genomic defects capable of driving the disease after a targeted drug knocks down one driver.

In this case, the patient was able to go home the day after the successful removal of multiple brain tumors.»

That is, they contained multiple populations of cells, including the so - called JARID1B cells, which their research suggested was responsible for allowing tumors to survive drug therapy.

HM - SNS allows researchers to sequence the genomes of single tumor cells and study multiple cells simultaneously, both lowering the cost and boosting data analysis for such studies.

«Having these personalized laboratory models, which we can make in a matter of weeks, will let us test multiple different drugs on the tumor and help us bring precision medicine to individuals with bladder cancer.»

Researchers from Uppsala University, Sweden, and the Broad Institute, USA, have identified both similarities and differences between a single tumor type in multiple dogs breeds; a finding they believe parallels the situation in the cancer of human patients.

Moreover, approximately 30 % of follicular lymphoma patients lose also a portion of chromosome 6, affecting multiple genes involved in suppressing the emergence of a tumor.

BETs have been fast - tracked into clinical trials and have shown impressive slowing of tumor growth in multiple cancer types.

A proteomic analysis of the tumors also identified multiple protein targets that have the potential to respond to drugs.

However, about 10 percent of them are common across multiple cancers, suggesting that a relatively small number of therapies targeting these core dependencies might each hold promise for combatting several tumors.

«The current study investigated the impact of dietary sugar on mammary gland tumor development in multiple mouse models, along with mechanisms that may be involved,» said co-author Lorenzo Cohen, Ph.D., professor of Palliative, Rehabilitation, and Integrative Medicine.

«Our results are the first to provide insight into ways of targeting multiple brain metastatic deposits with stem - cell - loaded oncolytic viruses that specifically kill dividing tumor cells.»

It is generally believed that a series of mutations in multiple genes are needed for cancer cells to become metastatic; however, recent cancer stem cell theory, which still remains as a hypothesis, predicts that metastatic tumor cells are, by definition, cancer stem cells and that these cells may exist in tumor mass even at an early stage.

After first verifying that stem cells injected to the brain would travel to multiple metastatic sites and not to tumor - free areas in their model, the team injected stem cells loaded with oHSV into the carotid artery of metastasis - bearing mice..

The Ludwig Center at the University of Chicago --- under the direction of Ralph Weichselbaum, MD, the Daniel K. Ludwig Professor and Chair of the Department of Radiation and Cellular Oncology, and Geoffrey Greene, PhD, the Daniel K. Ludwig Professor in the Ben May Cancer Research Institute at the University of Chicago — will focus on metastasis, the process by which cancer cells migrate from a primary tumor to multiple distant sites.

Bradner and Mitsiades had reported in Cell in 2011 that the inhibitor blocks the Myc cancer gene and thereby slows the growth of multiple myeloma tumors in mice.

We use multiple mouse models combined with in vitro approaches to address the pleiotropic functions of these cytokines which affect both the epithelial cancer cells and the inflammatory infiltrate within tumors.

Cas9 - expressing mice can dramatically accelerate our understanding of pathological processes that involve multiple genes or mutations, like tumor development.

Career Goals: I plan to pursue a career in scientific research focused in NKT cells which assist in prevention of autoimmune diseases such as diabetes, multiple sclerosis and tumors.

Drew Pardoll, Glenn Dranoff, Elizabeth Jaffee, Hyam Levitsky, and colleagues conduct preclinical studies showing that a vaccine composed of tumor cells irradiated and genetically modified to produce immune system growth factor GM - CSF (granulocyte - macrophage colony - stimulating factor)-- which would become known as the therapeutic cancer vaccine GVAX — could induce potent, specific, and long - lasting anti-tumor immunity in multiple mouse tumor models.