Sentences with phrase «of muscle weakness in»

A typical symptom of muscle weakness in dogs is your companion displaying severe weakness after only a short period of exercise.

Not exact matches

Biceps tendinitis (painful inflammation of the biceps tendon) and shoulder instability, in which structures that surround the shoulder joint do not work to maintain the ball within its socket, can all result from fatigue and weakness of the rotator cuff and muscles surrounding the shoulder blade.

Symptoms in infants include constipation, weakness (loss of muscle tone, weak cry, and weak sucking), droopy eyelids, and poor feeding due to difficulty swallowing.

Hypotonia or «floppy infant syndrome», which may occur with or without muscle weakness and cause abnormal control of the oropharyngeal structures, resulting in weak or uncoordinated sucking

Around one sixth of people in the UK aged over 75 have vitamin B12 deficiency, which when severe can lead to significant problems in the nervous system including muscle weakness, problems with walking, tiredness, and pins and needles, as well as depression and problems with memory and other important everyday cognitive functions.

It happens due to weaknesses in the structures supporting the bladder and bladder outlet (urethra), mainly the pelvic floor muscles, which then fail to stop urine leaking out when the bladder is under stress, such as when laughing or sneezing, or because of a weakness in the sphincter muscle which normally holds the urethra closed.

The study authors» recommendation of considering an implantable defibrillator even in patients with mild cardiac muscle weakness could introduce a paradigm shift in the approach to treatment.

In their study, Stephanie Cherqui, PhD, associate professor in the UC San Diego School of Medicine Department of Pediatrics, and colleagues used a transgenic mouse model that expresses two mutant human FXN transgenes, and exhibits the resulting progressive neurological degeneration and muscle weaknesIn their study, Stephanie Cherqui, PhD, associate professor in the UC San Diego School of Medicine Department of Pediatrics, and colleagues used a transgenic mouse model that expresses two mutant human FXN transgenes, and exhibits the resulting progressive neurological degeneration and muscle weaknesin the UC San Diego School of Medicine Department of Pediatrics, and colleagues used a transgenic mouse model that expresses two mutant human FXN transgenes, and exhibits the resulting progressive neurological degeneration and muscle weakness.

Mitochondrial defects are often observed in a variety of diseases, including cancer, Alzheimer's disease, and Parkinson's disease, and are the hallmarks of a number of genetic mitochondrial disorders whose manifestations range from muscle weakness to organ failure.

Using CRISPR / Cas9, the Hamon Center team was able to correct the genetic defect in a mouse model of DMD and thus prevent the development of features of the disease, which in boys causes progressive muscle weakness and degeneration, often along with breathing and heart complications.

«We also found that increasing muscle weakness — possibly due to decreasing testosterone concentration in the blood — could explain most of this relationship,» said Benjumin Hsu, MPH, the study's principal investigator and a PhD candidate at the University of Sydney.

«For nearly 20 years, we've thought that the muscle weakness observed in patients with Duchenne muscular dystrophy is primarily due to problems in their muscle fibres, but our research shows that it is also due to intrinsic defects in the function of their muscle stem cells,» said Dr. Michael Rudnicki, senior author of the study.

In a final set of experiments, the researchers used necrostatin - 1 to treat mice with axonal damage and hind leg weakness, a telltale sign of axonal demise similar to the muscle weakness that occurs in the early stages of ALS in humanIn a final set of experiments, the researchers used necrostatin - 1 to treat mice with axonal damage and hind leg weakness, a telltale sign of axonal demise similar to the muscle weakness that occurs in the early stages of ALS in humanin the early stages of ALS in humanin humans.

Scientists led by John Kuwada, professor of molecular, cellular and developmental biology at the University of Michigan, and Hiromi Hirata of the National Institute of Genetics in Japan originally identified the gene in mutant zebrafish that exhibited severe muscle weakness.

Symptoms of the disease, which typically appear in adolescence or early adulthood, include muscle weakness and decreased muscle size, loss of sensation and deformities in the feet and legs.

«Climb stairs to lower blood pressure and strengthen leg muscles: New study demonstrates effectiveness of stair climbing in helping prevent and treat menopause and age - related vascular complications and muscle weakness.»

The study could inform new treatments for a set of conditions known as peripheral neuropathies, which are caused by damage to the cells in the PNS and can lead to extreme sensitivity to touch as well as numbness and muscle weakness.

Lou Gehrig's disease, also known as amyotrophic lateral sclerosis, or ALS, attacks muscle - controlling nerve cells — motor neurons — in the brain, brainstem and spinal cord, leading to progressive weakness and eventual paralysis of muscles throughout the body.

Sarcopenia in people has two components: loss of muscle mass and loss of function (weakness).

Even without injuries, falls often lead to fear of falling, avoiding leaving the house and depression, which in turn often leads to inactivity, muscle weakness, impaired balance and gait, more falls and more social isolation.

Rapsyn mutations that result in receptors not clustering or functioning properly likely contribute to a wide range of muscle weakness seen in muscular dystrophy, Mei said.

Mitochondrial function in skeletal muscle of patients with protracted critical illness and ICU - acquired weakness.

It is characterized by the wasting of skeletal muscles and caused by progressive degeneration of nerve cells in the spinal cord; the disease leads to increasing muscular weakness, atrophy and premature death due to respiratory problems.

Over-activation of the inflammatory protein nuclear factor κB (NF - κB) in the brain region leads to a number of aging - related changes in mice, from cognitive decline to muscle weakness.

«SMA is a devastating disease that leads to the loss of motor neurons resulting in muscle weakness and respiratory failure in children.

The RyR1 is of fundamental importance for the development of muscle force and a decrease in its content may be causally linked to the profound muscle weakness seen in patients with some forms of congenital myopathies linked to recessive RYR1 mutations.

In this presentation, special emphasis will be given to the role of Ca2 + handling as a key regulator of (i) muscle weakness and (ii) beneficial adaptations observed after high intensity interval training.

The screening proposed here is expected to lead to novel strategies for the treatment of centronuclear myopathies by reducing muscle weakness caused by central nuclei in diseased muscles.

But they don't know why the lack of SMN protein causes spinal neurons to die, leading to muscle weakness in patients.

The mutation causes a loss of motor neurons in the spinal cord and wasting of skeletal muscles, leading to increasing muscular weakness and loss of function.

The findings demonstrate similarities in progressive muscle weakness and a decline in motor coordination in both models of motor neuron disease with a later onset and slower progression noted with PFN1 animals.

«Surprisingly, we found that the strength of the muscle itself was the same between the DS and control mice — suggesting that factors in the nervous system may play a more dominant role in explaining muscle weakness in DS,» said Cowley.

Mitochondrial defects are often observed in a variety of diseases, including cancer, Alzheimer's disease, and Parkinson's disease, and are the hallmarks of a number of untreatable genetic mitochondrial disorders whose manifestations range from muscle weakness to organ failure.

This study shows the importance of better understanding muscle weakness in DS.

Results from this model show evidence of myopathy and muscle weakness in the absence of neuron loss, which further indicate the intrinsic role of SMN in the muscle.

This may indicate that neural activation of the muscle plays a greater role in explaining weakness in persons with DS.

The investigators analyzed the soleus muscle — a muscle in the lower leg — and looked into whether the weakness was due to a deficiency of the muscle itself, independent of its activation by the nervous system.

A typical feature includes weakness of the foot and lower leg muscles, which may result in foot drop and a high - stepped gait with frequent tripping or falling.

The degeneration of motor nerves results in muscle weakness and atrophy in the extremities (arms, legs, hands, or feet), and the degeneration of sensory nerves results in a reduced ability to feel heat, cold, and pain.

Muscle weakness is the most common and prominent feature of SMA, leaving many patients suffering from difficulty in performing many basic motor functions.

Although in rare cases, individuals may have respiratory muscle weakness, CMT is not considered a fatal disease and people with most forms of CMT have a normal life expectancy.

It causes progressive weakness in muscles of the face, arms, legs, and around the shoulders and chest.

But perhaps more importantly, doing a lot of back work will also injury - proof your body in the most effective way possible, correcting any weaknesses and muscular imbalances in the back area and strengthening the spinal column and the supporting muscles, ligaments and tendons.

While it's common to have discomfort in the area during and post-pregnancy (as your pelvis widens to prepare for birth, ligaments stretch and tug on the joint, causing pain), many women experience it because of muscle tightness or weakness.

Symptoms develop quickly and include weakness in the legs and arms, muscle weakness and pain, the U.S. National Institute of Neurological Disorders and Stroke says.

The discomfort is often due to weakness of muscles in the knee, hip and other joints, so muscle - building exercises, such as squats, could be a good line of defense.

And too much protein restriction can actually contribute to aging in the form of muscle wasting, accompanied by increasing weakness and immune deficiencies.

Since protein is needed for calcium absorption and supporting bone metabolism, a diet low in protein will not only raise your risk of muscle loss, but it can also cause bone weakness, slow bone healing and fractures, apart from the muscle loss.

People should be watching for new nerve or muscle problems, such as feeling pins and needles or having a sensation of weakness in part of the body.

Bell's palsy occurs when a nerve in the face becomes swollen or inflamed, triggering symptoms like muscle weakness, drooling, a drooping eyelid or corner of the mouth, twitching, or paralysis, which can come on quickly.