The researchers analysed the genetic composition
of myocardial cells using state - of - the - art gene sequencing technology.
Not exact matches
Researchers from the Institute for Integrated
Cell - Material Sciences (iCeMS)
of Kyoto University and the Department
of Cardiovascular Surgery
of Osaka University have developed effective and convenient Cardiac Tissue - Like Constructs (CTLCs) for repairing
myocardial infarctions.
In addition we have added Dr. Topol's March 2012 research paper published in Science Translational Medicine, «Characterization
of Circulating Endothelial
Cells in Acute
Myocardial Infarction.»
For the purpose
of additional experiments, the researchers generated
myocardial cells from embryonic stem
cells and human skin
cells, in collaboration with the lab headed by Prof Dr Jürgen Hescheler at the University
of Cologne.
Moreover, in collaboration with Prof Dr Henrik Milting at the Heart and Diabetes Center in Bad Oeynhausen, the researchers from Bochum analysed isolated
myocardial cells from explanted hearts
of patients.
Dib has developed the methods
of catheter base stem
cell transplantation to treat
myocardial infarction using 3 - dimensional guidance technology, and has edited a book on stem
cell transplantation and tissue engineering for cardiovascular repair.
Removal
of gata5 from
cells normally destined to become
myocardial cells caused profound defects in the formation
of the heart.
«Discovery
of a gene that could convert human embryonic stem
cells into
myocardial cells would be golden,» said Didier Stainier, PhD, UCSF assistant professor
of biochemistry and biophysics, the senior author
of the UCSF study and a pioneer in the study
of heart development in the transparent zebrafish embryo.
«Using different regulators, scientists have been able to induce a subset
of myocardial characteristics in various experimental models, but never the complete beating phenotype, so there is something special about gata5 that can take a
cell that's not supposed to become a heart
cell to actually become one,» said Stainier.
The finding, the first discovery
of a so - called «master» gene for
myocardial, or heart muscle,
cells in an animal model, puts researchers on track for exploring the capability
of homologous genes in mice and humans.
Mesenchymal stem
cell - like
cells derived from human placenta can improve heart function in a mouse model
of myocardial infarction
Stem
cells affect the infarcted myocardium via neovascularization, reduction
of apoptosis and paracrine effect, they are able to increase
myocardial perfusion, inhibit synthesis
of pro-inflammatory cytokines (IL6 and TNFα) and promote expression
of anti-inflammatory cytokines (IL10) minimizing the necrosis damage caused by local inflammatory reaction.
Research Paper The human somatostatin receptor type 2 as an imaging and suicide reporter gene for pluripotent stem
cell - derived therapy
of myocardial infarction Katrien Neyrinck, Natacha Breuls, Bryan Holvoet, Wouter Oosterlinck, Esther Wolfs, Hubert Vanbilloen, Olivier Gheysens, Robin Duelen, Willy Gsell, Ivo Lambrichts, Uwe Himmelreich, Catherine M. Verfaillie, Maurilio Sampaolesi, Christophe M. Deroose Theranostics 2018; 8 (10): 2799 - 2813.
Intracoronary
cell injection allows direct supply
of the
cells to the entire infarcted
myocardial region.
The mutant mice had fewer
myocardial cells and disruptions
of the muscle integrity that eventually led to prenatal death.
Transplantations
of various stem
cells or their progeny have repeatedly improved cardiac performance in animal models
of myocardial injury; however, the benefits observed in clinical trials have been generally less consistent.
Myocardial infarction (MI) or acute myocardial infarction (AMI), commonly known as a heart attack, results from the interruption of blood supply to a part of the heart, causing heart cel
Myocardial infarction (MI) or acute
myocardial infarction (AMI), commonly known as a heart attack, results from the interruption of blood supply to a part of the heart, causing heart cel
myocardial infarction (AMI), commonly known as a heart attack, results from the interruption
of blood supply to a part
of the heart, causing heart
cells to die.
Transplantation
of mesenchymal stem
cells derived from the umbilical cord could represent an effective means to treat chronic
myocardial infarction
The impact
of the fatty meal on red blood
cells and MPO were new findings, and the authors indicated that «meals enriched in fat may promote destabilization
of vulnerable plaques leading to acute
myocardial infarction,» the medical term for a heart attack.
Parvovirus can also attack the rapidly - growing
myocardial (muscle)
cells of the heart in puppies born to a bitch who is not vaccinated against the disease.