† Myocardial Infarction (MI, Acute Myocardial Infarction, AMI, Non-ST Segment Elevation Myocardial Infarction, STEMI, Heart Attack): An acute interruption of vascular perfusion of any portion
of the myocardium (muscles of the heart) due to either an occlusion of a coronary artery or to vascular spasm causing damage to the myocardium.
There are two clinical forms of parvo virus in dogs, gastroenteritis and myocarditis (inflammation
of the myocardium which is the middle layer of the heart wall).
One long - term effect of Lyme disease is mycocarditis, an inflammation
of the myocardium of the heart.
Tachycardia can also increase the oxygen demand
of the myocardium, inducing arrhythmias.
Thickening
of the myocardium per se does not cause turbulent blood flow, hence many cats with HCM do not have a heart murmur.
Intra-myocardial injection of the cells with a thin needle is performed manually at defined target areas
of myocardium.
«MRI is a unique tool for studying heart tissue that enables us to explore in exquisite detail heart function, necrosis, the state of the microcirculation, and many other parameters that are critical in determining the post-infarction status
of the myocardium,» says Dr. Fuster.
Not exact matches
In pre-clinical experiments, hESC - derived cardiomyocytes engraft in damaged
myocardium and appear to behave like native cells; hESC - derived islet cells engraft, produce the hormones
of the endocrine pancreas, and appear to do so under homeostatic control; etc. \ n \ nThere is no evidence
of teratomas from differentiated hESC - derived cells and minimal, if any, immune rejection.
Formation
of Human
Myocardium in the Rat Heart from Human Embryonic Stem Cells.
Increased local delivery
of antagomir therapeutics to the rodent
myocardium using ultrasound and microbubbles.
Although medical and surgical treatments available today for the ischemic heart disease patients diminish the risk
of acute myocardial infarction and reduce to some extent the incidence
of recurrent heart attack, one
of the unsolved challenges is to affect
myocardium remodeling occurring during ischemic heart failure.
Stem cells affect the infarcted
myocardium via neovascularization, reduction
of apoptosis and paracrine effect, they are able to increase myocardial perfusion, inhibit synthesis
of pro-inflammatory cytokines (IL6 and TNFα) and promote expression
of anti-inflammatory cytokines (IL10) minimizing the necrosis damage caused by local inflammatory reaction.
In humans, LVNC is morphologically characterized by a severely thickened two - layered
myocardium consisting
of a thin compacted epicardial layer and a thick noncompacted endocardial layer.
Aoki et al. «In Vivo Transfer Efficiency
of Antisense Oligonucleotides Into the
Myocardium Using HVJ - Liposome Method», Biochemical and Biophysical Research Communications, 231: 540 - 545, 1997.
The resulting ischemia (restriction in blood supply) and ensuing oxygen shortage, if left untreated for a sufficient period
of time, can cause damage or death (infarction)
of heart muscle tissue (
myocardium).
Subjects were participants in the Women's Ischemia Syndrome Evaluation (WISE) who had reported chest pain and were thus suspected to suffer from myocardial ischemia (defined as pathological loss
of or reduction in blood flow — ischemia — to a part
of the muscular tissue
of the heart —
myocardium).
More interestingly, the effects on infarction size, survival rates and cardiac function can be observed even if the dietary intervention is induced after the ischemic event, by increasing the expression
of angiogenic factors and increased vascularization
of the damaged
myocardium, proposing a novel non-pharmacological therapy for subjects with chronic heart failure (43).
The release
of catecholamines in response to a painful stimulus results in tachycardia, hypertension, and an increase in oxygen consumption by the
myocardium.
Other potential treatments after careful consideration
of side - effects and that are recommended under the supervision
of a cardiologist include medications such as carvedilol and metoprolol or injections
of myoblasts (viable cells) into the
myocardium (heart muscle).
«We store aliquots
of cells for each individual patient and will evaluate the efficacy
of the adult stem cell transplantation into the dilated, failing
myocardium of DCM dogs.»
Cardiomyopathy is a disease where the actual heart muscle (
myocardium) becomes weak and unable to contract with sufficient force (decreased contractility leading to a decreased stroke volume) to provide adequate perfusion (reduced cardiac output) for the cells
of the body.
Looking a little closer at the anatomy
of the heart, it is a 4 - chambered organ primarily made
of specialized cardiac muscle known as
myocardium.
The Merck Veterinary Manual states that, «The cause [
of dilated cardiomyopathy in dogs] is still unknown although viral infection and resultant autoimmune reaction against the damaged
myocardium are suspect....