Barbareschi M, Pecciarini L, Cangi MG, Macri E, Rizzo A, Viale G, Doglioni C. p63, a p53 homologue, is a selective nuclear marker
of myoepithelial cells of the human breast.
Receptors on the surface
of the myoepithelial cells are designed to interact with a hormone, oxytocin, released during lactation.
Not exact matches
The tissue, called the stroma, includes fat
cells, or adipocytes, that provide padding; fibroblasts, which make the framework for tissue; pericytes in blood vessels, which are contractile
cells that help regulate blood pressure; as well as
myoepithelial cells comprising the outer layer
of the ductal system through which milk flows.
The basic components
of the mammary gland are the alveoli (hollow cavities, a few millimetres large) lined with milk - secreting cuboidal
cells and surrounded by
myoepithelial cells.
This interaction causes the
myoepithelial cells — on the outer layer
of the ductal structure — to contract, squeezing the luminal
cells within.
The
myoepithelial cells can contract, similar to muscle
cells, and thereby push the milk from the alveoli through the lactiferous ducts toward the nipple, where it collects in widenings (sinuses)
of the ducts.
Rare spontaneous myoepitheliomas arising from
myoepithelial cells of various exocrine glands have been observed in The Jackson Laboratory substrains.