We observed a modest decrease in cell cycling and some induction
of the neuronal marker beta - III tubulin, as quantified here.
Not exact matches
The neurons where then stained with a
marker of neuronal processes in red.
For neuroscientists finishing a Ph.D. program or a postdoctoral position, the mysteries
of neuronal circuits and genetic
markers for disease pale compared to one puzzling question: Where are the jobs?
Whilst the immune response to TBM sets up some
of the damage, this new research suggests that
markers of ongoing
neuronal injury are more predictive
of disease severity than
markers of immune response.
The neurons express a pan
neuronal marker Map2 in green and a percentage
of the cells express a
marker for inhibitory neurons, GABA, in red.
The green staining indicates the cortical
marker CTIP2, the red stain is the
neuronal marker TUJ1, and the blue stains the nuclei
of the cells.
Based on anatomy and molecular
markers, we propose that it arose by duplication
of a neighboring stem cell, which may have enabled finer
neuronal control over leg - related behaviors, such as walking and grooming.»
«We now have the first
marker for the capacity
of brain immune cells to remove toxic materials,» says Haass, «and its increase long before full Alzheimer's dementia shows that there is early
neuronal injury that does not yet affect memory, but already triggers a microglia response.»
«Even more importantly, we were interested in determining whether inflammatory
markers in plasma were independently linked to CSF
markers of AD - related pathology and
neuronal damage in a group
of healthy, community dwelling older adults.»
Bettcher also emphasized that although participants had detectable levels
of AD - related
markers and
markers of neuronal damage in their CSF, the presence
of these
markers alone does not indicate a diagnosis
of AD, nor does it mean that they will develop AD in the future.
«Results from our study suggest that although CSF
markers of inflammation are strong predictors, both plasma and CSF
markers of inflammation independently relay information about AD - related pathology and
neuronal damage in head - to - head comparisons,» Bettcher said.
The scientists had expected inflammation
markers in the CSF to be more robust predictors
of AD - related pathology and
neuronal damage than those in the blood due to the «blood brain barrier.»
Conducted among more than 170 subjects at various stages
of Alzheimer's disease, the study by the team led by Salah El Mestikawy (Douglas Mental Health University Institute, Canada) and Stéphanie Daumas (Université Pierre et Marie Curie, France) has shown instead that the disease is accompanied by a minor decline in
neuronal and synaptic
markers.
We combined a behavioral test for magnetic compass orientation in mole rats and immunocytochemical visualization
of the transcription factor c - Fos as a
marker of neuronal activity.
«Much to our surprise, in studying the fate
of eight
neuronal and synaptic
markers in our subjects» prefrontal cortices, we only observed very minor
neuronal and synaptic losses.
Using these direct electrical recordings, the team was able to test the level
of high frequency
neuronal activity (a
marker of neurons firing) in this region, a very precise measure which captures activity tied to cognition processes lasting mere hundreds
of milliseconds.
As part
of the webinar series, Abcam would like to offer you a 50 % discount on the following product ranges:
neuronal marker antibodies, Alexa Fluor ® conjugated secondary antibodies, agonists and antagonists, ion channel blockers and enzyme inhibitors and modulators.
For the detection
of specific antigens, the following primary antibodies were used: mouse monoclonal anti-Tuj1 (Covance, Princeton, NJ, USA) as a
neuronal marker, rabbit anti-L1 (kindly provided from Dr. Asou)[52] and rat monoclonal anti-L1 (Millipore, Billerica, MA, USA) as granule cell
markers, rabbit anti-calbindin D28K (Millipore) as a Purkinje cell
marker, and rabbit anti-glial fibrillary acidic protein (GFAP, DAKO, Denmark) as an astrocyte
marker.
Hippocampus glutamate and N - acetyl aspartate
markers of excitotoxic
neuronal compromise in posttraumatic stress disorder Rosso IM, Crowley DJ, Silveri MM, Rauch SL, Jensen JE.
By combining
neuronal tracing with behavioral experiments leading to sensory - driven gene expression
of the
neuronal activity
marker ZENK during magnetic compass orientation, we demonstrate a functional
neuronal connection between the retinal neurons and Cluster N via the visual thalamus.
The vast majority
of forebrain neurons in songbirds can express ZENK as a
marker for
neuronal activity [13], [14], [24]--[26] Feenders, Liedvogel, Zapka, Mouritsen, Jarvis, personal communication].
To do this, we combined
neuronal tracing with analyses
of ZENK expression as a
marker for
neuronal activity induced during behavioral experiments.
The proper placement
of retrograde tracer into Cluster N was proven by co-localization
of tracer and the
neuronal activity
marker ZENK, since Cluster N is the only part
of the forebrain displaying movement - independent ZENK activity in night - migratory birds sitting still or performing magnetic compass orientation under dim light conditions at night [13].
After 4 weeks
of differentiation, the majority
of the cells (> 60 %) expressed the postmitotic
neuronal marker β - III tubulin with a subset (about 50 %
of total neurons) additionally expressing TH, a
marker for midbrain dopaminergic neurons (Fig. 3A — D).
However, recent evidence indicates that apoE4 expression compromises the blood - brain barrier (as does apoE deficiency).40 Studies
of brain histology, neurodegenerative
markers, cholinergic activity, and
neuronal function in knockout mice have been equivocal.39 Failure
of detailed neurocognitive and retinal studies to demonstrate defects in our patient suggests either that the functions
of apoE in the brain and eye are not critical or that they can be fulfilled by a surrogate protein.