Sentences with phrase «of neuropathic»

He says that she suffered a «significant injury to her spinal cord at the C3 - 4 level, with consequential development of neuropathic pain in her neck and upper limbs.»

Gabapentin is used in both dogs and cats to treat chronic pain, particularly of neuropathic origin.

SM causes a wide variety of neuropathic symptoms due to damage and degeneration of the spinal cord.

However, for dogs with signs of neuropathic pain, i.e. allodynia and scratching behaviour (suspected dysesthesia); a drug which is active in the spinal cord dorsal horn is more likely to be effective.

Because the mechanisms of development of neuropathic pain are multifactorial, appropriate polypharmacy is likely to be more effective than treatment with single agents.

«This patent is a critical first step to securing broad exclusivity for AV411 and analogs in the key markets of neuropathic pain and addiction,» commented Andrew Sauter, Avigen's Chief Executive Officer, President and Chief Financial Officer.

The patent covers the treatment of neuropathic pain with therapeutic doses of AV411 (ibudilast), including syndromes like diabetic neuropathy, post-herpetic neuralgia, and fibromyalgia, and neuropathic pain associated with stroke or accompanying cancer chemotherapy.

Avigen Inc (NASDAQ: AVGN) has been granted a United States Patent for the treatment of neuropathic pain with its AV411 (ibudilast) compound.

Additional types of neuropathic pain have not been explored to date.

HDAC inhibitors ameliorate hypersensitivity in models of neuropathic pain.

The authors concluded that the right S2 cortex is a promising new target for the treatment of neuropathic orofacial pain with high - frequency rTMS.

Mechanical hypersensitivity, sympathetic sprouting and glial activation are attenuated by local injection of corticosteroid near the lumbar ganglion in a rat model of neuropathic pain.

However, people with neuropathic pain have very little choice when it comes to other treatment options because the cause of neuropathic pain is so poorly understood.

Indeed, in rats, she showed that giving morphine after nerve injury doubled the duration of neuropathic pain in the animals.

Henry MA, Fairchild DD, Patil MJ, Hanania, T, Hain HS, Davis SF, Malekiani SA, Hu A., Sucholeiki R, Nix D, Sucholeiki Effect of a novel, orally active matrix metalloproteinease - 2 and - 9 inhibitor in spinal and trigeminal rat models of neuropathic pain, Journal of Oral & Facial Pain and Headache 2014

Methods included the use of the Neuropathic Pain Questionnaire (NPQ), the Knee Injury and Osteoarthritis Outcome Score (KOOS, a multidimensional pain and functional assessment), an exercise performance task and quantitative sensory testing (QST).

Titled «Peripheral Hypersensitivity to Subthreshold Stimuli Persists after Resolution of Acute Experimental Disc - Herniation Neuropathy and Is Mediated by Heightened TRPV1 Receptor Expression and Activity,» the study promises to shed light on the basis of neuropathic pain that persists after apparently successful surgery.

This compound has been recently designated for phase III clinical trials to test its efficacy for treating epilepsy and providing relief of neuropathic pain.

The whole list takes just 15 minutes to complete and also distinguishes between three types of neuropathic pain.

«Genius,» said Dr. Moreau, «is but one of the many branches of the neuropathic tree.»

Not exact matches

The DOD - funded research will target the use of Sprint specifically for amputees suffering from moderate to severe neuropathic pain — chronic pain typically caused by nerve damage.

In an article posted on MD Anderson's blog, professor in the Department of Experimental Therapeutics, Dr. Bharat Aggarwal, Ph.D., points out that, «Symptoms common in cancer patients, such as depression, fatigue, neuropathic pain, metastases and tumor growth, are due to inflammation.

The story is an allegory for the death of Pirola's own father, John, who suffered for years through searing neuropathic pain as a result of a brain stem tumor, and over several years, underwent more than 10 brain / skull - based surgeries.

That was because everyone was being super careful about my neuropathic bladder, and because I was BF and drinking lots of fluids they wanted to check I was able to handle it.

The bill legalizes medical cannabis as a therapeutic treatment of 10 serious illnesses, including cancer, HIV / AIDS, Lou Gehrig's disease, Parkinson's disease, Huntington's disease, epilepsy, neuropathic diseases and multiple sclerosis.

In the medical realm some studies suggest brain stimulation might help people with neuropathic pain as well as depression, schizophrenia and a range of other psychiatric illnesses.

Neuropathic pain — chronic pain caused by nerve damage — is a significant problem, affecting around 8 per cent of Europeans.

New research in mice indicates that a drug commonly used to suppress the immune system in recipients of organ transplants may also reduce tissue damage and neuropathic pain after spinal cord injury.

In this latest study, the team examined whether rapamycin also reduces neuropathic pain, a state of chronic pain resulting from injury to the nervous system.

On the other hand, NPD1 = PD1 can relieve neuropathic pain at very low doses and, more importantly, mice receiving the treatment did not show signs of physical dependence or enhanced tolerance toward the lipid compound.

Over-active T - type channels are linked to epilepsy, cardiac problems, neuropathic pain, as well as the spreading of several kinds of cancer.

Most of the research has been on neuropathic pain because that kind of pain can be very difficult to treat.

«This bench to bedside research is very exciting and will have a major impact on the management of neurological diseases, particularly neuropathic pain,» said Akbar Panju, medical director of the Michael G. DeGroote Institute for Pain Research and Care, a clinician and professor of medicine.

The summarized data also showed that 8 % of UK adults experience chronic neuropathic pain, and 5.5 % live with fibromyalgia.

Using laboratory mouse models of inflammatory and neuropathic pain, they showed that the antibody can target the Nav1.7 channel and reduce the pain sensation in these mice.

Two studies investigating the use of cannabis for spasticity and three case report on use for neuropathic pain, post-traumatic stress disorder or Tourette syndrome all lacked controls or blinding, conferring a high risk of biased findings.

A way to treat neuropathic pain would block the stress signal causing it, instead of diminishing the nerve response.

It would take a horse pill of the current medication to quell neuropathic pain, Hammock says, but the compound has promise.

It turns out that neuropathic pain is triggered when the body experiences endoplasmic reticulum (ER) stress, a condition in which the production and transport of protein exceeds the cells» capacities, say researchers from the University of California, Davis.

Because diabetics are at high risk of having neuropathic pain, the team studied diabetic rats that had neuropathic symptoms: hypersensitivity to touch and lack of heat sensation.

«Clinically, these results indicate that neuropathic symptoms are very common in knee OA and that neuropathic processes — such as changes in conditioned modulation — predict who will respond to a common treatment for knee OA,» said Ajay D. Wasan, MD, MSc, the principal investigator, vice chair for Pain Medicine at UPMC, and a visiting professor at the University of Pittsburgh in Pennsylvania.

QST has been used to identify a range of sensory abnormalities in patients with neuropathic pain (Maier et al, Pain 2010; 150 (3): 439 - 50).

Diseases such as epilepsy, neuropathic pain, anxiety, depression, drug addiction and Alzheimer's are all associated with changes in the excitability of brain neurons.

Using CPM, an index of endogenous pain - inhibitory capacity that was calculated from QST measurements, investigators correctly predicted changes in pain intensity and in neuropathic symptoms (p <.05).

«These strategies would focus on promoting myelination in the peripheral nervous system for neuropathic disease or inhibiting Schwann cell over-proliferation that occurs during formation of peripheral nerve sheath tumors like neurofibromas.»

Combining morphine, a narcotic pain reliever, and nortriptyline, an antidepressant, has been found to successfully relieve chronic neuropathic pain — or a localized sensation of pain due to abnormal function of the nervous system — in 87 per cent of patients, and significantly better than with either drug alone.

In yet another application of human medicine in veterinary care, the team has treated Northstar with gabapentin (sold under the brand name Neurontin), a medication used for neuropathic pain in humans, to treat the severe itching and nerve - related pain that is typical in burn patients as they recover.

Upregulation of the voltage-gated sodium channel beta2 subunit in neuropathic pain models: characterization of expression in injured and non-injured primary sensory neurons.

This article is a review of commonly used medications for chronic pelvic neuropathic pain disorders as well as an introduction to recent innovative developments in pain medicine.

New research from King's College London has revealed a previously undiscovered mechanism of cellular communication, between neurons and immune cells, in neuropathic pain.