Sentences with phrase «of new genes through»

By tracking these two major markers, Treangen and Rocha calculated that the prokaryotes they studied acquired between 88 and 98 percent of new genes through horizontal transfer.

Not exact matches

Marshall points out that the relatively fast appearance of new animal species in this period is not driven by new genes, but rather by evolving from existing genes through «rewiring» of the gene regulatory networks (GRNs).

Data access and analysis tools are being made available for the 3K RGP dataset through the International Rice Informatics Consortium (IRIC), which promotes collaboration in bioinformatics analysis of rice data and provides computational tools to facilitate rice improvement via discovery of new gene - trait associations and accelerated breeding.

Professor Bruce Fitt, professor of plant pathology at the University of Hertfordshire, added: «This new understanding of plant defense through ETD suggests different operations of specific resistance genes which will help us to be more successful in breeding new strains of crops for resistance.

Standard forms of CRISPR gene drives, as the tools are called, can make tweaked DNA race through a population so easily that a small number of stray animals or plants could spread it to new territory, predicts a...

Standard forms of CRISPR gene drives, as the tools are called, can make tweaked DNA race through a population so easily that a small number of stray animals or plants could spread it to new territory, predicts a computer simulation released November 16 at bioRxiv.org.

The other initiates a new program of oscillations by activating genes that normally do not oscillate, principally through a factor called PPAR - gamma.

But at a meeting in June, the secretive group took stock of a new threat: gene drives, a genetic - engineering technology that can swiftly spread modifications through entire populations and could help vanquish malaria - spreading mosquitoes.

A decade of post-genomic biology has also focused new attention on the regions outside protein - coding genes, many of which are likely to have key functions, through regulating the expression of protein - coding genes and by making a slew of non-coding RNA molecules.

But by investigating the DNA sequence around the resistance genes, the team figured out how the resistance genes transfer occurred through a new mechanism named «carry back,» where the pathogen basically has a primitive form of «sex» with the Actinobacterium and takes up its resistance genes after it dies.

For his part, Collins, who has led NIH since 2009 and been kept on by the Trump administration, pointed to an array of promising NIH activities, including the development of new technologies to provide insights into human brain circuitry and function through the Brain Research through Advancing Innovative Neuroethologies (BRAIN initiative) and the use of the gene - editing tool CRISPR - Cas9 to correct mutations and clear the way to develop and test a «curative therapy» for the first molecular disease: sickle cell disease.

The three Ras genes found in humans — H - Ras, K - Ras and N - Ras — were among the first to be linked to cancer development, and a new study led by VCU Massey Cancer Center researcher Paul Dent, Ph.D., has shown the recently approved breast cancer drug neratinib can block the function of Ras as well as several other oncogenes through an unexpected process.

«It makes it much easier for researchers working with barley to be focused on attainable objectives, ranging from new variety development through breeding to mechanistic studies of genes.»

The most obvious way for a new gene to evolve is through the gradual accumulation of small, beneficial mutations.

He worries that a live vaccine that uses Vibrio strains whose virulence genes have been removed may still be capable of getting new virulence genes through its integron.

«The bugs are somehow driving gene expression in the host through alteration of the epigenome,» explains John Denu, a UW - Madison professor of biomolecular chemistry and a senior researcher at the Wisconsin Institute for Discovery, and a co-author of the new study.

Through colorful anecdotes and commonsense explanations, author Richard C. Francis, who holds a Ph.D. in biology, delivers an engaging tour of the new science of epigenetics, the study of environmental influences on gene expression.

«New technology could reduce spread of antibiotic resistance genes through compost.»

The new scheme to chart the «history and geography of human genes» through DNA analysis of far - flung «primitive» peoples rests on the mistaken assumption that such exotics do not have a history, says Marks.

But the study, conducted through the new USTAR Center for Genetic Discovery at the U of U, shows that Phevor's unique approach allows it to identify disease - causing genes more precisely than other computational tools.

That scene came to mind as I sorted through the tawdry verbal wreckage on social media and in print of the «debate» over CRISPR, the revolutionary new gene - editing technology.

In a series of studies this year, molecular geneticists at the University of Pittsburgh School of Medicine used a harmless virus to ferry new genes through the bloodstream, across blood vessel walls, and into almost every muscle cell in the bodies of hamsters bred to have human genetic diseases.

In human trials, researchers remove some of patients» T cells through a process similar to dialysis and then engineer them in a laboratory to add the gene for the CAR so that the new receptor is expressed in the T cells.

And, in the future, the potential to insert barcodes in genes and the development of in - line ID kits, that recognize specific strains of cell lines, could make it easier to verify new organisms and their protein products, and track products through supply chains.

Through a process called recombination, which had not previously been seen in influenza viruses, parts of the human and swine virus genes had joined together to create a totally new antigen, one that human immune systems were unprepared for (Science, 11 May, p. 1041).

In a paper in the high - impact journal Cell Research, published April 4, 2017, researchers at the Hebrew University of Jerusalem report the discovery of an entirely new mechanism through which globin genes are expressed.

In fact, our present understanding of morphogenesis indicates that new phyla were not made by new genes but largely emerged through the rewiring of the gene regulatory networks (GRNs) of already existing genes (1).

«These results opened up a whole new avenue of investigation for us, and through that investigation we found a new function for this gene.»

A new study, by researches at Uppsala University, shows now that the memory of a heart attack can be stored in our genes through epigenetic changes.

«The bugs are somehow driving gene expression in the host through alteration of the epigenome,» explains John Denu, a UW — Madison professor of biomolecular chemistry and a senior researcher at the Wisconsin Institute for Discovery, and a co-author of the new study.

A new way to make specific genes spread faster through insect populations has been developed, paving the way for novel methods of combating insect - borne diseases such as malaria.

Other research at U-M is developing new options for treating brain cancer through immunotherapy — harnessing the immune system to attack cancer cells once an injection of a particular gene therapy is delivered into the brain tumor.

This narrow view has been becoming overshadowed by genetic findings that support the more recent hypothesis of complex roots, which emphasizes lateral genetic exchanges or horizontal gene transfers (HGT) rather than vertical mutational progression in the development of nucleated organisms, through a clearly defined «tree of life» (Mark Buchanan, New Scientist, January 26, 2010).

Most recently, she has led the planning and execution of a program for a new gene therapy product candidate, from ideation through proof - of - concept study, and mapping out the development plan.

When they increased the concentration of PU.1, however, the cells quickly passed through a transitory mixed lineage state and produced new regulatory proteins that activated macrophage genes and repressed neutrophil genes.

In the second study, a team led by Shahin Rafii at Weill Cornell Medicine in New York City used adult mouse cells as their starting material, and then guided them through several steps — including exposure to some of the same gene - activating proteins — to create mature blood stem cells in a petri dish.

For discovery of new cancer genes and mutational processes, aggregation of tens of thousands of cancer genomes is needed — we are establishing a virtual marketplace for exchange of genomes and informatics and develop increased functionality through the COSMIC portal.

Similar to how the neck on a soda bottle restricts the amount of liquid that gets through, the frontier dogs would bring only some of their community's genes with them into a new area.

Beverly Emerson studies how different genes are turned on and off through the course of a cancer — from the time cells become precancerous until the time they develop into a mature cancer and spread to new organs.

Through systematic annotation of the resulting movies, we developed a phenotypic profiling system, which shows high correlation with cellular processes and biochemical pathways, thus enabling us to predict new functions for previously uncharacterized genes.

GMOs, or «genetically modified organisms,» are living things whose genetic material has «incorporated new genes from one species into a completely unrelated species through genetic engineering, optimizing agricultural performance or facilitating the production of valuable pharmaceutical substances from two species,» according to

The program is unique in its concentration of nationally and internationally recognized leaders in the areas of new drug development, cell and gene therapy and design and conduct of both local and national clinical trials through the Children's Oncology Group (COG).

Test each mutant mouse line (4,000 mouse lines in the first 5 years, and ultimately up to 20,000) through a broad based primary phenotyping pipeline in all the major adult organ systems and most areas of major human diseases.Through this activity and employing data annotation tools, systematically aim to discover and ascribe biological function to each gene, driving new ideas and underpinning future research into biological systems.

A significant percentage of children and young adults with treatment - resistant B - cell leukemia achieved remission through a new CAR T - cell gene therapy that destroys cancer cells with the CD22 molecule on its surface.

Introducing new DNA often is achieved by viral transduction of target cells with a therapeutic transgene, through either a direct or cell - based gene therapy modality.

Indeed, they found that the synthesized proteins that diffused through the array of interconnected compartments were able to regulate genes and produce new proteins in compartments farther along the network.

To address this challenge, the International Mouse Phenotyping Consortium is creating a genome - and phenome - wide catalog of gene function by characterizing new knockout - mouse strains across diverse biological systems through a broad set of standardized phenotyping tests.

Howard Hughes Medical Institute researchers have combed through a catalog of all known tyrosine kinase enzymes to identify new gene mutations that occur in a significant fraction of colon cancers...

In fact, through improving our understanding, it gives us new ways of understanding how the HD gene causes Huntington's disease, and adds «abnormal splicing» to our list of possible targets for solving the problem.

Data access and analysis tools are being made available for the 3K RGP dataset through the International Rice Informatics Consortium (IRIC), which promotes collaboration in bioinformatics analysis of rice data and provides computational tools to facilitate rice improvement via discovery of new gene - trait associations and accelerated breeding.