Sentences with phrase «of niche cell»
Looking further into the intestinal crypts of both the transgenic and wild - type mice, the research team made what they consider a surprising finding: Not only was HMGA1 causing the stem cells themselves to self - renew or proliferate more rapidly in the transgenic animals, but it was also increasing the number of Paneth cells, a type of niche cell known to support intestinal stem cells.
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In that spot, the scientists found a niche of angioblasts, those same cells that a hundred years earlier were thought to be the source of lymph vessels, but were later neglected.
But as the research in Yaniv's lab progressed, it became clear that scientists on both sides of the argument had been right: Lymphatic cells do indeed grow from veins, but they originate from a niche within the vein that harbors angioblasts.
Researchers from the Department of Biomedicine at the University of Basel have now found that the fate of adult hippocampal stem cells is not only controlled by their local niche, but also by a cell - intrinsic mechanism.
Not only the root's stem - cell niche is located there, the root tip also accommodates sensors for an auxin - dependent growth of the plant based on gravitation.
Future research should not only compare how embryonic stem cells, iPS cells and adult stem cells differentiate, but focus on what effects the niche in which these cells will reside, when transplanted, will have on their characteristics, including tendencies to mutate into cancer cells, notes cell and stem cell biologist Olga Genbacev at the University of California, San Francisco, (U.C.S.F.) School of Medicine.
The therapeutic use of stem cells is a promising area of medicine for the decades ahead and researchers are examining why stem cells function in certain types of niches, microenvironments, and pockets of activity.
«The instructions that the female niche is supplying to the male cell do not coordinate with each other,» says Clark, a member of the consortium.
«We believe that our experiments provide the first example of a factor that both expands the intestinal stem cell compartment and builds a niche.»
They also plan to evolve the chemistry behind the materials so that it may be possible for gels to better mimic more complex cellular environments beyond the control of stiffness alone, as well as investigate how dynamic changes in matrix properties — a hallmark of the stem cell niche — can be mimicked in the laboratory.
From the French word nicher, which means to build a nest, a niche is a nest - like compartment comprised of cells that secrete growth factors and other proteins that help stem cells survive.
«Single gene encourages growth of intestinal stem cells, supporting «niche» cells, and cancer: Finding in mice could lead to new therapies for damaged organs, cancer.»
Researchers saw that injecting the miR - 34a mimic in mice could prevent the metastasis of breast and skin cancer cells specifically to bone, mainly by disarming the metastatic niche in bone.
In the adult central nervous system, the vasculature of the neurogenic niche regulates neural stem cell behavior by providing circulating and secreted factors.
However, when the tips of these blood cells begin to sprout, the thrombospondin - 1 proteins give way to TGF - beta 1 and periostin proteins in the neovasculature, turning it into a metastatic niche that not only permits but accelerates the growth of breast cancer cells.
The niche prevents stem cells from being depleted, while protecting the body from over-production of stem cells.
Researchers with the U.S. Department of Energy (DOE)'s Lawrence Berkeley National Laboratory (Berkeley Lab) have identified the microenvironment surrounding microvasculature — the small blood vessels that transport blood within tissues — as a niche where dormant cancer cells reside.
To determine whether endothelial cells — the cells that line the interior surface of blood vessels — directly influence breast cancer cell growth, they then created unique organotypic models of lung and bone marrow microvascular niches, in which endothelial cells formed blood vessel - like structures in culture as they would in the original organ.
«The recent discovery of tumor - promoting milieus, referred to as metastatic niches, that are established at distant sites prior to or upon the arrival of disseminated tumor cells could explain cancer cells that relapse early, but in late relapsing populations, what tumor cells do from the time of dissemination to the time they become clinically detectable has been a big question.»
Understanding stem cell niches is therefore important in the field of stem cell therapeutics.
This research provides new insights into the structure of the stem cell niche in health and after injury.
Given that breast cancer cells traveling through the bloodstream on their way to secondary sites where breast tumors metastasize most often — lung, bone marrow, brain and liver — must first pass through the basement membrane microvasculature, Ghajar and Bissell suspected that the basement membrane could be a major component of the dormant niche in distant organs.
Understanding the role of the niche requires identifying the key cell types that regulate the numerous processes that take place within the niche.
«We don't yet know if this type of coordination and control works in stem cell niches of other tissue types,» says DiNardo.
Where the concentration of WOX5 is high enough, the stem cell niche is able to maintain the pluripotent stem cells.
HSCs are a type of adult stem cell that live in little niches in the bone marrow.
Stem cell populations reside in areas called niches deep within different types of organs.
Stephen DiNardo, PhD, a professor of Cell and Developmental Biology and Kari F. Lenhart, PhD, a postdoctoral scientist in the DiNardo lab, study the development of fruit fly sperm as a model to investigate the stem cell - niCell and Developmental Biology and Kari F. Lenhart, PhD, a postdoctoral scientist in the DiNardo lab, study the development of fruit fly sperm as a model to investigate the stem cell - nicell - niche.
Techniques enabling the isolation of specific cell populations have advanced our ability to identify and characterize niche cell types which may be used to replace or engineer cells / tissue.
But how the production of daughter cells from the different stem cell types is coordinated within a single niche is virtually unknown.
The use of cell surface markers to isolate specific cell populations is one common method for separating cells; however, isolating live cells based on their RNA expression is a powerful new way enabling the study of small cell niches in nongenetically modified animal models and human tissue.
In this case, the niche residing at the tip of the testis is the site of stem cell divisions, which are critical to produce daughter cells that later become sperm.
«We have found a way by which cytokinesis is temporarily halted and later started back up, and this phenomenon coordinates all cell players in the maturation of sperm cells in this niche,» says DiNardo.
What's more, the timing of that separation is controlled by neighboring stem cells in the niche.
In addition, many niches contain different stem cell types, each necessary to produce the distinct types of cells needed for tissue renewal.
«LEVER 3 - D is amazing, it opens new vistas for understanding the stem cell niche,» said Dr. Sally Temple, a cell biologist at the Neural Stem Cell Institute in Rensselaer, N.Y. who has been using Cohen's software, through the course of its development, as part of her stem cell research since 2cell niche,» said Dr. Sally Temple, a cell biologist at the Neural Stem Cell Institute in Rensselaer, N.Y. who has been using Cohen's software, through the course of its development, as part of her stem cell research since 2cell biologist at the Neural Stem Cell Institute in Rensselaer, N.Y. who has been using Cohen's software, through the course of its development, as part of her stem cell research since 2Cell Institute in Rensselaer, N.Y. who has been using Cohen's software, through the course of its development, as part of her stem cell research since 2cell research since 2005.
This striking finding shows that regulation of cytokinesis is how this niche coordinately produces daughter cells from different stem cell types.
Abd - B is essential for the positioning and function of the stem cell niche.
Engineering a megakaryocyte niche (a special environment in which stem cells live and renew) that supports the growth of hematopoietic stem cells in culture, is the next step for the researchers.
He is known for showing how niches of neural stem cells constantly regenerate parts of the rodent brain.
The lab previously found that Bam is required to repress the expression of E-cadherin, a cell - to - cell adhesion molecule that tethers adult stem cells to their tissue niches and promotes GSC self - renewal.
The research team led by Prof. Fiona Doetsch at the Biozentrum of the University of Basel has now shown that the choroid plexus is a key component of the stem cell niche, whose properties change throughout life and affect stem cell behavior.
«Because the hematopoetic stem cell niche is so important for the creation of bone marrow and blood cells and because Del - 1 is a soluble protein and is easily manipulated, one can see that it could be a target in many potential applications,» said George Hajishengallis, the Thomas W. Evans Centennial Professor in the Department of Microbiology in Penn's School of Dental Medicine and a senior author on the work.
Barbara Beltz of Wellesley College in Massachusetts knew from Petri dish experiments that crayfish blood cells — haemocytes — are attracted to the niche.
Each cell will split into two daughter cells, precursors to full neurons, both of which migrate out of the niche.
Contained in spongy bones, the bone marrow microenvironment and its «niches» support production of platelets and other blood cells.
Presumably, a scaffold provides some sort of microenvironment — a niche that allows a cell to adopt the normal 3D morphology that it would have in the body.
In the breast, the ducts designed to carry milk during and after pregnancy are composed of two highly specialized cell types and a niche of stem cells that gives rise to both types.
This Registered report describes the proposed replication plan of key experiments from «Interactions between cancer stem cells and their niche govern metastatic colonization» by Malanchi and colleagues, published in Nature in 2012 (Malanchi et al., 2012).
Therefore, miR - 7 / KLF4 pathway may facilitate a reciprocal interaction of CSCs and these brain cells that generates a suitable niche for CSCs, although this hypothesis needs to be experimentally tested.