Sentences with phrase «of noncoding»

With the sequencing and annotation of genomes and transcriptomes of several eukaryotes, the importance of noncoding RNA (ncRNA)- RNA molecules that are not translated to protein products - has become more evident.

Using genome - scale RNA interference (RNAi) screening and other high - throughput methodologies to uncover the functions of noncoding RNAs in the mammalian system, the McManus Lab has generated and characterized many small (micro) RNA conditional knockout mice.

Almost all of the noncoding RNAs (ncRNAs) known are shared between the two species.

For example, some forms of noncoding RNA (meaning it's not involved in translation to proteins) have epigenetic activity.

RNA - seq analysis detected aberrant splicing in DONSON due to one of these noncoding variants, showing a causative role for DONSON disruption in MMS.

It suggests that all of those noncoding genetic associations are not random, but indicative of the intricate regulatory genetic networks underlying complex human traits.

The researchers zeroed in on a single - nucleotide polymorphism (SNP) that appeared to be the causal mutation, typically consisting of an adenine nucleotide but appearing as a guanine nucleotide in roughly a third of the population, located in a region of noncoding DNA that falls within the PHACTR1 gene.

Sessions will cover recent findings in RNA polymerase II regulation, including the contributions of noncoding RNAs, chromatin structure and post-translational modifications, and other factors that regulate gene expression.

As our understanding of the noncoding portion of the genome improves, it will become even more apparent that whole - genome sequencing (and not exome sequencing) will be required to characterize the full extent of phenotypically - relevant genetic variation in humans.

It should be noted, however, that the typing method used here is based on the analysis of a noncoding spacer region within the rRNA gene cluster of B. burgdorferi [16, 19, 28, 35].

One of the noncoding de novo mutations was 254 kilobases downstream of FGFR2, in a noncoding region that looks (according to chromatin marks) like a neural crest enhancer.

TSSs for protein - coding genes were more conserved than those of noncoding RNAs.

J H S Tong and colleagues report a study that brings into sharp focus the likely relevance of noncoding variants for the genetic risk associated with Attention deficit hyperactivity disorder (ADHD).

The researchers classified pri - miRNAs into three broad categories based on gene structure: Class I, which are transcribed independently of other genes and likely represent independent transcription units, Class II, which are transcribed as an extension of a protein - coding gene, and Class III, which are transcribed as an extension of a noncoding RNA.

One example of a Class III pri - miRNA is located upstream of the noncoding RNA SPACA6P and encodes miR - 99b, let - 7e, and miR - 125a.

Recently, researchers have focused on the ability of noncoding RNA, the portion of our genome that does not contribute to the production of proteins, to regulate a variety of biological processes.

The team then bred the mice and checked their offspring for DNA mutations.The mice born to males that breathed unfiltered air had up to 2.8 times more mutations in particular stretches of noncoding DNA than did mice with fathers that breathed filtered air, or clean air at a rural site.

MicroRNAs (miRNA) are a class of noncoding RNAs with lengths of approximately 22 nucleotides that bind to target messenger RNAs to inhibit protein translation.

Understanding the role of these noncoding mutations is a «challenging task,» says Ivan Iossifov, associate professor at Cold Spring Harbor Laboratory in New York, who was not involved in the study.

To provide a molecular basis for understanding N - CAM function, the complete amino acid sequences of the three major polypeptides of N - CAM and most of the noncoding sequences of their messenger RNA's were determined from the analysis of complementary DNA clones and were verified by amino acid sequences of selected CNBr fragments and proteolytic fragments.

One way to control expression, he explains, is through microRNA, small pieces of noncoding genetic material that control whether a gene's protein is generated from the DNA blueprints inside cell nuclei.

However, in the context of large amounts of noncoding genomic data, the phylogenomic signal in the exon data adds support to the species tree.

To their surprise and dismay, the genome turned out to contain long stretches of noncoding and repetitive DNA, which made it difficult to piece together the short reads produced by the sequencing machine.

An oncogenic super-enhancer formed through somatic mutation of a noncoding intergenic element

«Two classes of GGAA - microsatellites in a Ewing sarcoma context: Characterization of GGAA - microsatellites provides insight in the role of noncoding DNA in cancer susceptibility and therapeutic development.»

Researchers measured the levels of microRNAs — tiny snippets of noncoding RNA — in the saliva of concussion patients.

Characterization of the noncoding regulatory landscape within human - specific duplicated regions.

«By identifying this major regulator of noncoding editing in C. elegans we can now focus on dissecting the regulatory mechanism and determining the conservation of this regulatory protein in human cells.»

The shadow cast has been so deep that a whole universe (or so it seems) of RNA — predominantly of the noncoding variety — has remained hidden from view, until recently.

The shared patterns of gene expression in the limbs and phallus are generated in part by a common set of noncoding DNA, also called «elements» or «enhancers,» which act to control gene expression in both of these structures, argues a study published October 1 in Developmental Cell.

Sebat's team was especially interested in the parts of noncoding DNA that regulate gene expression.

The conclusion is that many of these noncoding regions of DNA should be more broadly categorized as «appendage enhancers» rather than «limb enhancers,» and snakes may have retained these noncoding DNA elements due to their role in phallus development.

Not exact matches

This type of RNA was different, though, in that it didn't make up or code for the instructions of a protein like a traditional gene but instead was «noncoding.»

Sebat says the large noncoding portion of our DNA — often previously referred to as «junk DNA» — has so far been ignored in autism research.

The researchers detected this SMN long noncoding RNA, or lnc - RNA (pronounced «link RNA») for short, in human embryonic kidney cells, brain cell samples and neurons derived from the stem cells of healthy people and those with spinal muscular atrophy type I and II.

Peixoto finds the paternal bias surprising as well, although she already suspected that the inherited component of autism would be more apparent in noncoding regions.

«This was what first led us to start an effort to identify novel genomic regulatory elements to explore the noncoding portion of the genome.

Assessing the influence of individual DNA base changes is particularly difficult in noncoding regions, so they instead identified bigger alterations, so - called structural variants, in which large sequences of DNA are inverted, duplicated, or deleted.

Small noncoding microRNAs (miRNAs) have been found in such abundance that they have been christened the «dark matter» of the cell, a view reinforced by an analysis of the small RNAs found in Arabidopsis (pp. 1567 and 1525).

Once dismissed as «junk DNA,» researchers have found that some of these so - called noncoding regions are shared among mammals, suggesting they play an important function.

Some of the transcripts hail from noncoding DNA, the researchers report, but those that do match up with the 399 ENCODE genes overlap with each other extensively.

Deep - sequence coverage allowed identification of 263 iSNVs (73 nonsynonymous, 108 synonymous, 70 noncoding, and 12 frameshift) in the Sierra Leone patients (6).

In a series of elaborate experiments researchers from Harvard Medical School and Brigham and Women's Hospital discovered that mouse poop is chock full of tiny, noncoding RNAs called microRNAs from their gastrointestinal (GI) tracts and that these biomolecules appear to shape and regulate the microbiome.

Elevated amounts of a viral noncoding RNA that suppresses host immunity likely led to an outbreak of dengue virus.

The epidemic strain produced elevated amounts of subgenomic flavivirus RNA (sfRNA), a viral noncoding RNA, relative to amounts of genomic viral RNA.

Many are probably simply the consequence of 6 million years of genetic drift, with little effect on body or behavior, whereas other small changes — perhaps in regulatory, noncoding sequences — may have dramatic consequences.

«People used to call the noncoding regions junk DNA, but I see it as a jungle that has not been explored,» said Christopher Gregg, Ph.D., assistant professor in Neurobiology and Anatomy at U of U Health.

«The elephant results revealed noncoding sequences in the human genome that we predict may control gene activity and reduce the formation of mutations and cancer.»

«We are exploring the noncoding regions to try to discover new parts of the genome that might control different diseases.»

The research team is turning their attention to the noncoding region of the mammalian genome.