Sentences with phrase «of normal genes»

This is an example of normal genes put together in an aberrant situation.

When the researchers then inserted a copy of the normal gene back into clk - 1 mutants, these worms lived a normal life - span.

Targeted gene therapies, however, had to wait for (1) the identification of the genes to target, (2) the cloning and / or sequencing of the relevant genes and in some cases, the specific disease - causing variant, (3) a full understanding of the normal gene function and regulation, and (4) the development of efficient ways to deliver genes to the relevant tissues at therapeutic levels.

Specifically, use of post-mortem material is crucial for studying the patterns of normal gene expression underlying tissue specificity within individuals, as sampling such tissues from living individuals would be impossible.

Positive Heterozygous (1 copy of the mutated gene and 1 copy of a normal gene) Dogs that are positive heterozygous should be carefully evaluated for signs of disease (Holter monitor and possibly an echocardiogram).

NORMAL / CLEAR - the dog has two copies of the normal gene and it is not going to develop L -2-hydroxyglutaric aciduria caused by the mutation in the L2HGDH gene.

The Curly Hair test: The Curly Hair test allows one to determine the genotype of a tested dog as being normal / clear of the KRT71 mutation (i.e. having two copies of the normal gene); a carrier of one copy of the mutation; or a homozygote for the KRT71 mutation (i.e. having two copies of the mutant variant).

CARRIERS - heterozygotes with one copy of the mutation and one copy of the normal gene do not develop NAD but they can transmit the PLA2G6 mutation to progeny.

NORMAL - the dog has two copies of the normal gene and it is not going to develop Day Blindness / Retinal Degeneration caused by the DB / RD mutation.

CARRIER - the dog has one copy of the normal gene and one copy of the DB / RD mutation.

Not exact matches

While the entity generated by deleting or disabling early embryonic genes would produce only an unorganized collection of stem cells, it would do so after a period of what appears to be relatively normal development.

Sickle cell trait is the inheritance of one gene for sickle hemoglobin and one for normal hemoglobin.

Guys who are rated as the most masculine — a billboard for a man's good genes — tend to have more testosterone, and men with higher testosterone levels are 43 percent more likely to get divorced than men with normal levels, 31 percent more likely to split because of marital problems and 38 percent more likely to cheat.

Early life stress, such as an extreme lack of parental affection, has lasting effects on a gene important to normal brain processes and is also tied to mental disorders.

The speed and degree of this transition depends largely on your normal body size, how much weight you gained during pregnancy, how active you are, and your genes.

If you're a carrier of a defective gene for a recessive disorder, that means you have one normal copy of the gene from one of your parents and one defective copy from the other.

But, if a father passes on the «twin gene» to his daughter, then she may have a higher chance than normal of having fraternal twins.

Luckily for me, a few hours of sleep, a supportive family, and lucky genes were all it took to feel normal again.

Gene Russianoff, an attorney for the Straphangers Campaign, a transportation advocacy group, said that such horse - trading was a normal part of how policy gets made in New York.

In experiments with mice, the researchers found that Paneth cells engineered to lack a functional ATG16L1 gene were five times more likely to die in the face of rising TNF - alpha signals than normal cells.

It has been assumed that activation of HOX genes turns normal blood cells into leukemia cells by initiating stem cell - like self - renewal.

Both mouse and human males typically die early from the mutation in Mecp2, because their Y chromosome does not supply a normal copy of the gene.

The scientists are also experimenting with gene therapy, using a harmless virus to deliver a normal copy of the normal CIB2 gene to baby mice that have the mutated version.

We reasoned that if the hypothesis was correct, we might be able to find the src gene (the oncogene of the Rous sarcoma virus) in the DNA of normal cells.

But they do seem to have some interest in the opposite gender: Sometimes these parthenogens are mate with males of different species, creating a species with 50 percent more genes than normal.

To account for the remarkable similarity between retrovirus oncogenes and their normal cellular kin, most virologists have settled on the idea that retrovirus oncogenes are copies of cellular genes.

When normal and gene - altered mice got the high - fat diet along with varying levels of doxycycline, to induce GLP1 release, the normal mice grew fat and mice expressing GLP1 showed less weight gain.

And their genes are easier to manipulate than those of their mammalian counterparts — by altering Sod1, Wu created flies that died after only about two weeks, a quarter of their normal life span.

Philadelphia — Ten years ago this month the promise of using normal genes to cure hereditary defects crashed and burned, as Jesse Gelsinger, an 18 - year - old from Tucson, Ariz., succumbed to multiorgan failure during a gene therapy trial at the University of Pennsylvania.

When normal and gene - altered mice ate the high - fat diet — along with varying levels of doxycycline to induce GLP1 release — mice expressing GLP1 (left) gained less weight gain while normal mice (right) grew fat.

Blood measurements found startling differences in the biochemistry of the sheep carrying the HD gene, compared to the normal sheep.

Carlo Croce, a cancer researcher at Ohio State University in Columbus, and his colleagues created a diagram of interacting miRNAs for normal body cells by connecting them according to which genes they target and the function of those genes, in a way similar to analyses of human social networks.

Dr Paul Waters, an ARC fellow in the School of Biotechnology and Biomolecular Sciences at UNSW Australia, says that the X and Y chromosomes started their existence as normal autosomes (non-sex chromosomes) harbouring the same genes.

The identified mutation in the CNGB1 gene prevents the generation of normal protein in the dog's eyes.

The study's 31 samples of dog tumors was compared to 40 normal canine tissues samples as a way of estimating the variance in gene expression.

The findings jibe with previous reports that PCR tests sometimes overlook a gene with large deletions, detecting only the other, normal copy of the gene.

Studies have shown that more than 50 % of all human cancers carry defects in the p53 gene, and almost all other cancers with a normal p53 function carry other defects which indirectly impair the cancer - fighting function of p53.

Such plants have two mutant copies of a gene called hothead, which differ from the normal gene by a single base pair.

Using RNA sequencing, the researchers found multiple genes whose abnormal expression could lead to the high rate of death for cloned embryos, including failure to implant in the uterus and failure to develop a normal placenta.

Four days later, the livers of the non-supressed mice had readjusted to a normal daily rhythm, as revealed by the daily rise and fall of liver - gene expression.

Finally, the team identified a network of genes in these regions that exhibit changes in expression when the normal boost from serotonin is lacking, and these changes depended on how long the drug was given.

Women tend to be protected from diseases related to genes on the X because female cells randomly inactivate one of the X chromosomes, and that leaves some cells with a normal copy up and running.

Even when each parent carried two mutant versions of the gene, 10 percent of the next generation had normal flowers.

This «demethylation» turns on genes that direct stem cells to mature, and to start a count - down toward self - destruction as part of normal turnover.

When the researchers bred female flies containing the yellow gene drive to normal males, 95 to 100 percent of both male and female progeny were yellow.

After fishing stem cells from each individual's own blood, the researchers inserted a normal version of the ABCD1 gene into some of the cells and transplanted them back into the kids.

Fay notes that people who harbor one mutated copy of the gene seem to have normal blood clotting, so blocking PAI - 1 might not trigger dangerous bleeding.

Tissue taken from mice with the C. elegans gene had significantly higher levels of omega - 3 acids compared with that of normal animals, the team found.

A gene that follows normal 50 - 50 rules of inheritance (yellow lines) would not overtake the population.

Murphy found that the normal pattern of gene activation seen in aging wild - type C. elegans was reversed in the body cells and oocytes of IGF - 1 mutants.