Sentences with phrase «of novel sequencing»

Recently, genome assemblies using Oxford Nanopore MinION data have attracted much attention due to the portability and low cost of this novel sequencing instrument.

Identification of a novel sequence in PDZ - RhoGEF that mediates interaction with the actin cytoskeleton.

Identification of a novel sequence element in the common promoter region of human collagen type IV genes, involved in the regulation of divergent transcription

[69] Dorothy Richardson was the first English writer to use it, in the early volumes of her novel sequence Pilgrimage (1915 — 67).

Not exact matches

These include a fantastic sequence in which Scout and Jem and Dill play the main parts of a revivalist meeting that culminates in Dill's grandly appearing as nothing less than the Holy Ghost, but not before the children have a pointed argument about denominational differences — Methodist vs. Baptist — and related liturgical practices (how's that for dating the novel?).

What is your favourite book?A Dance to the Music of Time by Anthony Powell, a sequence of 12 novels that look at political, military and cultural life over a 50 - year period in the 20th century through the eyes of the narrator, Nick Jenkins.

Through detailed genome comparisons, sequence - alignment algorithms and other bioinformatics tools run on Los Alamos computers, the Los Alamos team identified features that differentiate among F. tularensis and other novel clinical and environmental Francisella isolates, providing a knowledge base for comparison of new sequences from clinical or environmental surveys.

The investigators found a total of 457 mostly novel phage sequences in the urinary microbiome.

Researchers at Stanford University purified the proteasome from the malaria parasite and examined its activity against hundreds of different peptide sequences using a novel method developed at the University of California, San Francisco.

Two study aims were to use novel whole - genome sequence data to (1) study possible correlations between language groups and genetic clustering, and (2) investigate the ancestral compositions of these individuals, including maternal and paternal lineages.

A majority of the bacterial sequences corresponded to uncultivated species and novel microorganisms.

He says that HLI's actual data are sound, and he is impressed with the group's novel method of determining age by sequencing the ends of chromosomes, which shorten over time.

Using a novel combination of technologies, including trio exome sequencing of patient / parental DNA and genetic studies in the tiny larvae of zebrafish, the EuroEPINOMICS RES consortium found that mutations in the gene CHD2 are responsible for a subset of epilepsy patients with symptoms similar to Dravet syndrome — a severe form of childhood epilepsy that is in many patients resistant to currently available anti-epileptic drugs.

Roswell Park Cancer Institute (RPCI) researchers used deep T - cell receptor (TCR) sequencing to evaluate the clonal composition of TILs and identify novel prognostic biomarkers in ovarian cancer.

«Our research explores a novel approach to treating mite allergy in which specially - encapsulated miniscule particles are administered with sequences of bacterial DNA that direct the immune system to suppress allergic immune responses,» says Peter Thorne, public health professor at the UI and a contributing author on the paper.

The sequencing of the human genome is gearing up all those efforts, and with each novel model organism for which the sequence has been determined, the power of comparative analysis increases.

We analyzed 7.2 terabases of metagenomic data from 243 Tara Oceans samples from 68 locations in epipelagic and mesopelagic waters across the globe to generate an ocean microbial reference gene catalog with > 40 million nonredundant, mostly novel sequences from viruses, prokaryotes, and picoeukaryotes.

Rubin introduced her to a then - novel discipline called metagenomics, which involves sequencing the collective genome of all the microbes in a given location.

His laboratory develops and deploys new biochemical and computational methods in functional genomics, to elucidate the genetic basis of human disease and human physiology, and to create and deploy novel techniques in next - generation sequencing and algorithms for tumor evolution, genome evolution, DNA and RNA modifications, and genome / epigenome engineering.

The institute's president, Craig Venter, had left the National Institutes of Health a few years back because it wouldn't fund his novel approach to genome sequencing; it was too radical and unlikely to succeed, the reviewers thought.

By only analysing DNA sequences that bind to cohesin, roughly one per cent of the genome, it would allow us to analyse an individual's mutations and make it much easier to conduct studies to identify novel harmful mutations,» Martin Enge concludes.

Three years earlier, investigators had found genetic sequences of the novel retrovirus in prostate tumors from men with that disease.

Described in a study published in the journal Nature Communications, this novel approach uses high - speed atomic force microscopy (AFM) combined with a CRISPR - based chemical barcoding technique to map DNA nearly as accurately as DNA sequencing while processing large sections of the genome at a much faster rate.

In a study published February 14, 2017 in the journal Genome Biology, an international team including researchers at the U.S. Department of Energy Joint Genome Institute (DOE JGI), a DOE Office of Science User Facility, report sequencing the genomes of 10 novel Aspergillus species, more than doubling the number of Aspergillus species sequenced to date.

In a novel type of experiment, regularly arranged atoms in a crystal are set into vibration by a laser pulse and a sequence of snapshots is generated via changes of x-ray absorption.

M1 RNA, the catalytic RNA subunit of Escherichia coli ribonuclease P, can cleave novel transfer RNA (tRNA) precursors that lack specific domains of the normal tRNA sequence.

By manipulating the genetic sequences, characterizing the resulting metabolites and using radioactive labeling experiments it was possible to elucidate the structure of the novel molecules and to unravel the detailed biosynthetic pathways.

Comparing these genetic sequences with known data implied that they might be responsible for the synthesis of novel natural products.

A systematic search of the nonrecombining region of the human Y chromosome (NRY) identified 12 novel genes or families, 10 with full - length complementary DNA sequences.

Furthermore, besides offering valuable insight into the function of this novel RNA type, the researchers also believe that the findings will open new avenues for novel treatments in which cell - specific enhancer sequences can be targeted to alter gene expression.

Researchers from Sanford Health and Chronix Biomedical today announced that results from a pilot study demonstrating the utility of a new cancer panel to detect previously undetected viral and cancer mutations are to be reported in a poster presentation titled «Detection of novel HPV mutations and chromosomal number imbalance (CNI) in oropharyngeal and laryngeal cancer using next - generation sequencing (NGS)» at the American Society of Clinical Oncology Annual Meeting (ASCO 2014) being held from May 30 through June 3, 2014 in Chicago.

«Tim and I were able to work very closely in all the steps of the project from the experimental design in the wet lab to the final analysis of the results; the major challenge was how to handle the very large number of barley samples and for this we designed a novel approach to sequencing that exploited deep results in combinatorics,» Lonardi said.

The study showed that the direction and extent of eRNA transcription and H3K4me1 / 2 regions show strong correlation and that the inhibition of eRNA transcription with polymerase inhibitors inhibited histone methylation and thus also the emergence of novel enhancer sequences.

The research team, co-led by Dr Rollins and Professor Bill Sherwin of UNSW, in collaboration with the Department of Agriculture and Food in Western Australia, studied the DNA of 279 starlings near Munglinup in the south east of Western Australia and identified birds with a novel mitochondrial genome sequence (Haplotype H).

Examining genome sequence information for more than 250,000 people, the researchers first uncovered 16 new diabetes genetic risk factors, and one new CHD genetic risk factor; hence providing novel insights about the mechanisms of the two diseases.

This work yielded the draft sequence of a waterfowl - duck for the first time, and the data indicated that the duck, like the chicken and zebra finch, possessed a contractive immune gene repertoire comparing to those in mammals, and it also comprises novel genes that are not present in the other three birds (chicken, zebra finch and turkey).

The researchers learned that the astonishing diversity of cadherin in pink bollworm from India is caused by alternative splicing, a novel mechanism of resistance that allows a single DNA sequence to code for many variants of a protein.

Conventional methods for identification of both RP mutations and novel RP genes involve the screening of DNA coding sequences.

As genomic sequencing methods continue to identify large numbers of novel cancer mutations, how can we identify the mutations in a given tumor that are most critical to the maintenance of its oncogenic phenotype?

Roswell Park Comprehensive Cancer Center researchers used deep T - cell receptor (TCR) sequencing to evaluate the clonal composition of TILs and identify novel prognostic biomarkers in ovarian cancer.

Using novel techniques to extract and study ancient DNA researchers at the Max Planck Institute for Evolutionary Anthropology in Leipzig, Germany, have determined an almost complete mitochondrial genome sequence of a 400,000 - year - old representative of the genus Homo from Sima de los Huesos, a unique cave site in Northern Spain, and found that it is related to the mitochondrial genome of Denisovans, extinct relatives of Neandertals in Asia.

In addition, the significant number (> 1000) novel models that came from RNA - Seq that were absent from the zebrafish cDNAs suggests that the deep sequencing offered by RNA - Seq can be used to expand the gene annotation of even well - studied model organisms.

Over the next 18 months, deCODE and Pfizer will work together to analyse the genomes of patients to search for sequence variants that would be useful for understanding drug targets and discovering novel drug targets, that may ultimately lead to tools for patient stratification and companion diagnostics.

An out - of - frame overlapping reading frame in the ataxin - 1 coding sequence encodes a novel ataxin - 1 interacting protein.

Comparison of archaeal and bacterial genomes: computer analysis of protein sequences predicts novel functions and suggests a chimeric origin for the archaea.

The large volume of sequence data from novel organisms generated by metagenomic projects has triggered the development of specialized databases and tools focused on particular groups of organisms or data types.

The ability of Nanopore sequencing to define the complete exonic structure of CACNA1C allows us to identify known and novel gene isoforms, including novel exons and multi-exonic skipping events and their expression across multiple brain regions.

Dr. Mody is leading a clinical trial investigating the role of next generation sequencing (NGS) in precision oncology for developing novel biomarkers and therapeutic targets against refractory childhood cancers.

Collaborating with the labs of Salk Professors Joseph Ecker and Alan Saghatelian, the Izpisua Belmonte team performed extensive characterization of the new cells and found rsPSCs showed distinct molecular and metabolic characteristics as well as novel epigenetic signatures — that is, patterns of chemical modifications to DNA that control which genes are turned on or off without changing the DNA sequence.

This project indicated that not only a vast number of novel potentially functional variants in a total of 231 pharmacogenes was identified but also demonstrated the value of whole - genome sequencing for pharmacogenomic testing by capturing over 18,000 variants per individual in these pharmacogenes.