Sentences with phrase «of nuclear factor»

Cucurmin fights inflammation, protecting the cells of the body from oxidative stress caused by free radicals, and inflammation, mainly due to the inhibition of nuclear factor KB.

Ginger extract and zingerone ameliorated trinitrobenzene sulphonic acid - induced colitis in mice via modulation of nuclear factor - κB activity and interleukin - 1β signaling pathway.

Another more common example is cigarette smoke, which causes chronic inflammation in the lungs, producing oxidation (and free - radicals) and leads to DNA damage and chronic obstructive pulmonary disease as well as lung cancer.6 A hallmark of both of these processes in the activation of nuclear factor - Kappa B (NF - KB), which is a protein complex that the body produces in response to inflammation, free radicals, cytokines, all hallmarks of stress.

Additionally, berberine strongly inhibited activation of nuclear factor - kappaB (NF - κB), a major contributor to inflammation.

In separate experiments, an adenoviral construct inhibiting IKKβ, an upstream component of the nuclear factor kappa - b (NFkB) pathway, was a priori injected into the NAc.

Abbreviations: Aβ, amyloid β - peptide; AD, Alzheimer's disease; ALS, amyotrophic lateral sclerosis; Ambra1, activating molecule in Beclin -1-regulated autophagy; AMPK, AMP - activated protein kinase; APP, amyloid precursor protein; AR, androgen receptor; Atg, autophagy - related; AV, autophagic vacuole; Bcl, B - cell lymphoma; BH3, Bcl - 2 homology 3; CaMKKβ, Ca2 + - dependent protein kinase kinase β; CHMP2B, charged multivesicular body protein 2B; CMA, chaperone - mediated autophagy; 2 ′ 5 ′ ddA, 2 ′, 5 ′ - dideoxyadenosine; deptor, DEP - domain containing mTOR - interacting protein; DRPLA, dentatorubral pallidoluysian atrophy; 4E - BP1, translation initiation factor 4E - binding protein - 1; Epac, exchange protein directly activated by cAMP; ER, endoplasmic reticulum; ERK1 / 2, extracellular - signal - regulated kinase 1/2; ESCRT, endosomal sorting complex required for transport; FAD, familial AD; FDA, U.S. Food and Drug Administration; FIP200, focal adhesion kinase family - interacting protein of 200 kDa; FoxO3, forkhead box O3; FTD, frontotemporal dementia; FTD3, FTD linked to chromosome 3; GAP, GTPase - activating protein; GR, guanidine retinoid; GSK3, glycogen synthase kinase 3; HD, Huntington's disease; hiPSC, human induced pluripotent stem cell; hVps, mammalian vacuolar protein sorting homologue; IKK, inhibitor of nuclear factor κB kinase; IMPase, inositol monophosphatase; IP3R, Ins (1,4,5) P3 receptor; I1R, imidazoline - 1 receptor; JNK1, c - Jun N - terminal kinase 1; LC3, light chain 3; LD, Lafora disease; L - NAME, NG - nitro - L - arginine methyl ester; LRRK2, leucine - rich repeat kinase 2; MIPS, myo - inositol -1-phosphate synthase; mLST8, mammalian lethal with SEC13 protein 8; MND, motor neuron disease; mTOR, mammalian target of rapamycin; mTORC, mTOR complex; MVB, multivesicular body; NAC, N - acetylcysteine; NBR1, neighbour of BRCA1 gene 1; NOS, nitric oxide synthase; p70S6K, ribosomal protein S6 kinase - 1; PD, Parkinson's disease; PDK1, phosphoinositide - dependent kinase 1; PE, phosphatidylethanolamine; PI3K, phosphoinositide 3 - kinase; PI3KC1a, class Ia PI3K; PI3KC3, class III PI3K; PI3KK, PI3K - related protein kinase; PINK1, PTEN - induced kinase 1; PKA, protein kinase A; PLC, phospholipase C; polyQ, polyglutamine; PS, presenilin; PTEN, phosphatase and tensin homologue deleted from chromosome 10; Rag, Ras - related GTP - binding protein; raptor, regulatory - associated protein of mTOR; Rheb, Ras homologue enriched in brain; rictor, rapamycin - insensitive companion of mTOR; SBMA, spinobulbar muscular atrophy; SCA, spinocerebellar ataxia; SLC, solute carrier; SMER, small - molecule enhancer of rapamycin; SMIR, small - molecule inhibitor of rapamycin; SNARE, N - ethylmaleimide - sensitive factor - attachment protein receptor; SOD1, copper / zinc superoxide dismutase 1; TFEB, transcription factor EB; TOR, target of rapamycin; TSC, tuberous sclerosis complex; ULK1, UNC -51-like kinase 1; UVRAG, UV irradiation resistance - associated gene; VAMP, vesicle - associated membrane protein; v - ATPase, vacuolar H + - ATPase; Vps, vacuolar protein sorting

Abbreviations: ASC, apoptosis - associated speck - like protein containing a caspase - recruitment domain; ATM, adipose - tissue - resident macrophage; BAT, brown adipose tissue; CCR2, CC chemokine receptor 2; CHOP, C / EBP (CCAAT / enhancer - binding protein)- homologous protein; DHA, docosahexaenoic acid; EPA, eicosapentaenoic acid; ER, endoplasmic reticulum; GPCR, G - protein - coupled receptor; HIF, hypoxia - inducible factor; IFNγ, interferon γ; IKK, inhibitor of nuclear factor κB kinase; IL, interleukin; IRS - 1, insulin receptor substrate - 1; JNK, c - Jun N - terminal kinase; LDL, low - density lipoprotein; Ldlr, LDL receptor; LXR, liver X receptor; MCP - 1, monocyte chemoattractant protein 1; miRNA, microRNA; mTOR, mammalian target of rapamycin; NAFLD, non-alcoholic fatty liver disease; NF - κB, nuclear factor κB; NLRP3, NLR (nucleotide - binding - domain - and leucine - rich - repeat - containing) family, pyrin - domain - containing 3; oxLDL, oxidized LDL; PKR, double - stranded RNA - dependent protein kinase; PPAR, peroxisome - proliferator - activated receptor; STAT6, signal transducer and activator of transcription 6; SVF, stromal vascular fraction; TLR, Toll - like receptor; TNFα, tumour necrosis factor α; UPR, unfolded protein response; WAT, white adipose tissue

Osteoblasts modulate osteoclast activity through secretion of the TNF family member RANKL (receptor activator of nuclear factor κB ligand).

Targeted disruption of nuclear factor erythroid - derived 2 - like 1 in osteoblasts reduces bone size and bone formation in mice.

Several NOD proteins have been implicated in the induction of nuclear factor - κB activity and in the activation of caspases.

Pinellia ternata lectin exerts a pro-inflammatory effect on macrophages by inducing the release of pro-inflammatory cytokines, the activation of the nuclear factor -?

A conserved domain of ∼ 300 amino acids that is found in the amino - terminal region of nuclear factor - κB (NF - κB)- family members.

By functionally linking the signal transduction of melanopsin to the control circuit of the nuclear factor of activated T cells, we have designed a synthetic signaling cascade enabling light - inducible transgene expression in different cell lines grown in culture or bioreactors or implanted into mice.

In animal studies, activation of nuclear factor - kappa B (NF - kB); activation of inducible nitric oxide synthase (iNOS), and cyclooxygenase - 2 (COX - 2); and formation of malondialdehyde (MDA) have all be shown to get reduced following consumption of either sweet potato or its color - containing extracts.

Not exact matches

The group quickly determines the mission team's potential strength (knowledge of the terrain), potential weakness (susceptibility to disease), assumptions being factored into the decisions (they do not face nuclear, biological, or chemical weapons), things they must not do (damage property, which would lead to loss of popular support), the principle information requirements, high - value targets, and so on through a checklist of easily overlooked considerations.

The protection factor that various buildings, and locations within them, offer from the radioactive fallout of a nuclear blast.

There could be several factors that had investors on edge — including news that North Korea had completed a fifth nuclear missile test and the European Central Bank had declined to announce additional measures to help stimulate Europe's sluggish economy — but many strategists pointed to a speech Friday morning by Federal Reserve Bank of Boston President Eric Rosengren, in which he said that «a reasonable case can be made» for tightening interest rates in the U.S..

With massive and increasing structural deficits; exploding debt in all sectors; hostile demographics; social and political fracturing and disintegration; grotesque wealth inequality; extraordinary global trade competition; a complete collapse of respect for vital government organizations such as the Justice Department and FBI, which the people now realize have gone rogue; an extremely complex and corrosive global geopolitical environment; the real prospect of war, potentially nuclear and worldwide; not to mention numerous additional factors, we can only point to few other times in history more dangerous to the people's financial welfare, and therefore more overall bullish for gold, one of the only financial sanctuaries proven to work in times of dislocation.

The OAR proposal uses a variation of therapeutic cloning called altered nuclear transfer (ANT) in which the nucleus of a donor cell (a skin cell, for example), containing the 30,000 genes of the genetic code, is altered in such a way that it produces an epigenetic factor, a protein called nanog.

In my view, there are at least six key factors which have caused and continue to affect a global transformation of consciousness: the revolution in communications, globalization of the economy, a growing awareness of the degradation of the environment, demographic shifts, the threat of nuclear destruction and the advent of the new science.

@Chad: I. Mutations in DNA sequences generally occur through one of two processes: A. Environmental factors: DNA damage from environmental agents such as ultraviolet light (sunshine), nuclear radiation or certain chemicals B. Mistakes that occur when a cell copies its DNA in preparation for cell division.

All these factors heighten the importance of the present nuclear debate.

Another school of thought assumes that the threat of nuclear war has radically altered this traditional relationship, which was perennial only in appearance but was in fact dependent upon certain ephemeral factors no longer present today.

The faith - group programs, representing Protestant, Catholics, and Jews, have consistently provided documentaries, dramas, and discussions which dealt with issues almost never touched by commercial broadcasting: the economic factors behind nuclear armaments; the issues behind draft evasion (during the Vietnam War); the real causes of worldwide starvation; and the problems of people who are ignored almost completely by the media, such as the aging who can not live on their pensions, unwed mothers, farm workers who have no homes, undocumented aliens whom we wish to employ but not pay, and refugees we are sending back to certain death in their own countries.

Combating inflammation According to the JNCI, Capsaicin blocks the activation of nuclear transcription factors in the cells» nuclei that, when activated by exogenous or endogenous free radicals or toxins, cause inflammation throughout the stomach and body.

Most of those were relatively early in the Cold War (ie less nuclear threat) and were either peripheral allies or there were other factors at play (Yugoslavia took advantage of Russian instability at the end of the Cold War)

Most of the commonly occurring cancers, notably breast, prostate, and lung cancer, spread (metastasize) to bone; I was set to the task of studying the role of a transcription factor (gene - expression regulator), NF B (nuclear factor kappa B), in cancer metastasis.

«The explanation is, in brief, that in metals, irradiation produces on picosecond time scales a liquid - like zone, which during the cooling - down phase recombines much of the initially produced damage, leading to a factor of 1/3 reduction in damage,» says Professor Kai Nordlund who was in lead of the team on search for more accurate predictions of usability of materials in nuclear environments, that now present their results freshly in Nature Communications.

This risk factor pushes the «levelized» or all - in price of nuclear power from new units to 8.4 cents per kilowatt - hour, the MIT study concludes, versus 6.2 cents for coal - fired plants and 6.5 cents for natural gas generation (if gas is priced at $ 7 per million British thermal units, or roughly 1,000 cubic feet of flowing gas).

So is it possible to uniquely identify an underground nuclear explosion (UNE) among the many factors disturbing the ionosphere's fluctuating swirls of particles?

This compares with EDF's average load factor for its French nuclear fleet of 73 percent in 2013, which is also down from its highest level of 77.6 percent in 2005, the company's 2013 results show.

By building a physical framework for this motion, we can identify key factors in the nuclear structure and function as well as expand the field of stochastic polymer dynamics.

While the average U.S. nuclear plant in 1980 had a capacity factor of less than 60 percent, today's average is over 90 percent.

In collaboration with the University of Texas Southwestern Medical Center (UTSW) in Dallas, the researchers found that the tumor - suppressive activity of geranylgeraniol was accompanied by down - regulation of HMG CoA reductase, a key enzyme in the mevalonate pathway that provides essential intermediates for the posttranslational modification of growth - related proteins such as Ras, nuclear lamins and insulin - like growth factor receptors.

For example, nuclear factor - kappa B (NF - kB) is a complex of proteins that acts as a master switch for turning inflammation genes on and for controlling cell death.

A likely factor is the problem that DNDO has run into with its Advanced Spectroscopic Portal (ASP) program, which was started in 2004 to screen cargo at land and sea borders for signatures of nuclear material.

Working with cultures of respiratory tract cells, Elias's team found that the gene that codes for il - 6 is inactive unless a protein known as nf - kb (nuclear factor - kappa beta) attaches to the gene.

She obtained her Ph.D. from Ulster University in Northern Ireland, United Kingdom, studying the activity of nuclear - receptor transcription factor pathways in cancer.

«It was crucial to find out that synthesis of the anti-inflammatory cytokine IL - 10 by the B lymphocytes through the interaction with the protein «nuclear factor of activated T cells» (NFATc1), a transcription factor, was reduced,» Matthias Goebeler puts the study's central result in a nutshell.

The predictors include «Online Mendelian Inheritance in Man» (OMIM, a list of genetically caused diseases), receptors, kinases, growth factors, transcription factors, tissue specific, plasma membrane localization, nuclear localization and conversation index.

Researchers led by Ludwig - Maximilians - Universitaet (LMU) in Munich physicists Peter Thirolf, Lars von der Wense and Benedict Seiferle have now experimentally identified a long - sought excitation state, a nuclear isomer in an isotope of the element thorium (Th), which could enhance this level of accuracy by a factor of about ten.

They later showed that RORA, a nuclear hormone receptor that functions as a transcription factor, can potentially regulate the transcription of more than 2,500 genes, including over 400 genes already associated with autism.

As a monomer, GR represses the activities of pro-inflammatory transcription factors, such as activator protein 1 or nuclear factor kappa B (NF - kB) by a tethering mechanism called transrepression.

We demonstrated the technique on 20 different biological processes spanning four orders of magnitude in space and time, including the binding kinetics of single Sox2 transcription factor molecules, 3D superresolution photoactivated localization microscopy of nuclear lamins, dynamic organelle rearrangements and 3D tracking of microtubule plus ends during mitosis, neutrophil motility in a collagen mesh, and subcellular protein localization and dynamics during embryogenesis in Caenorhabditis elegans and Drosophila melanogaster.

The branch uniting the fungi and animals is well - supported based on a number of molecular phylogenetic datasets, including the nuclear small subunit ribosomal RNA gene (Wainwright et al., 1993; Bruns et al. 1993), unique and shared sequence insertions in proteins such as elongation factor 1α (Baldauf and Palmer, 1993), entire mitochondrial genomes (Lang et al., 2002), and concatenated protein - coding genes (Steenkamp et al., 2006).

Loss of tumor suppressor p53 decreases PTEN expression and enhances signaling pathways leading to activation of activator protein 1 and nuclear factor kappaB induced by UV radiation.

Lin, R., Heylbroeck, C., Pitha, P. M. & Hiscott, J. Virus - dependent phosphorylation of the IRF - 3 transcription factor regulates nuclear translocation, transactivation potential, and proteasome - mediated degradation.

Sustained activation of nuclear erythroid 2 - related factor 2 / antioxidant response element signaling promotes reductive stress in the human mutant protein aggregation cardiomyopathy in mice.

In addition, it is now clear that mutations due to environmental factors can occur during the course of a lifetime in both nuclear and mitochondrial DNA, so even if clones were initially identical genetically, they would be unlikely to stay so during the course of their lifetimes.

Marchantia is a novel emerging plant model species and will be used together with Arabidopsis in this project to investigate and compare the interactions of ROXY proteins with transcription factors and their nuclear activities during land plant evolution.