The first in her family to earn a doctoral degree, Dr. Higa completed her thesis at the University of Utah in Oncological Sciences where she studied the roles
of nuclear pore proteins in nuclear export and nuclear envelope breakdown.
Saccharomyces cerevisiae Ndc1p is a shared component
of nuclear pore complexes and spindle pole bodies.
Probing structural and functional relationships
of the nuclear pore complex: ProQuest.
The nucleoporins Nup58 and Nup45 are part of the central transport channel
of the nuclear pore complex, which is thought to have a flexible diameter.
It also clumped up in the same location as abnormal clumps
of nuclear pore proteins NUP88 and NUP62.
Not exact matches
In pursuit
of answers, Munroe runs computer simulations,
pores over stacks
of declassified military research memos, solves differential equations, and consults with
nuclear reactor operators.
He was the first to measure the transition
of a messenger RNA through the
nuclear pore complex, determining that it was orders
of magnitude faster than expected and that the rate - limiting steps in this process are at the
nuclear and cytoplasmic surfaces.
Pores, composed
of many different proteins, the nucleoporins, cross the
nuclear envelope and monitor the heavy traffic
of the molecules, which takes place between the nucleus and the cytoplasm
of the cell.
The
nuclear pores thus create an environment conducive to the efficient production
of gene copies.
Françoise Stutz, professor in the Faculty
of Science at the University
of Geneva (UNIGE), Switzerland, and her team have just discovered how
nuclear pores also regulate the production speed
of these DNA copies.
Researchers from the University
of Seville at the Andalusian Centre for Molecular Biology and Regenerative Medicine (Centro Andaluz de Biología Molecular y Medicina Regenerativa — Cabimer) have discovered that in eukaryotic cells the proximity
of the genes to the
nuclear pores, which are found in the
nuclear membrane, contributes to maintaining the integrity
of the genome.
The proximity and anchoring
of the genes to the
nuclear pores during transcription has been known
of for more than a decade.
According to the researchers, there is an average
of 2000
nuclear pores per cell and each individual
nuclear pore consists
of multiple copies
of more than 30 different proteins that each serve different functions.
Because
of such clues from others» research, Grima took on the task
of investigating whether problems with
nuclear transport and the
nuclear pores also happened in neurons with Huntington's disease.
Grima also observed this same clumping
of Huntingtin protein with RanGAP1 and
nuclear pore proteins to the wrong place in the cell in brain tissue and cultured brain cells derived from deceased patients with Huntington's disease.
«In this work, we have seen that if DNA is located in the interior
of the nucleus and removed from the
nuclear pore, the formation
of DNA - RNA hybrids are more likely.
From one collection
of mutations
of protein coding genes, they identified the
nuclear components Mlp1 and Mlp2
of the macrocomplex that form the
nuclear pores, preserved in all the eukaryotes, including the human ones.
By
poring over images from commercial satellites and freely available seismic data, a scientist in London has pieced together a detailed picture
of China's secret
nuclear weapons testing site.
Pores in the
nuclear envelope consist
of tetramers with a variable lateral offset that may allow the opening to be adjusted according to the size
of molecules passing through.
In healthy cells, RanGAP helps transport molecules through
nuclear pores that connect a cell's cytoplasm — the liquid that fills most
of a cell — and the nucleus — the central compartment containing genetic material.
Molecular mechanisms and functions
of SUMOylation;
nuclear pore complexes and control
of nucleocytoplasmic transport.
High - resolution three - dimensional mapping
of mRNA export through the
nuclear pore.
Super-resolution 3D tomography
of interactions and competition in the
nuclear pore complex.
Internalization
of C60 fullerenes into cancer cells with accumulation in the nucleus via the
nuclear pore complex.
Amo1 is not required for the microtubule loading
of several factors affecting microtubule dynamics, and does not seem to be required for
nuclear pore function.
«It will be one
of the hardest forms
of damage to repair via rejuvenation biotechnology; the only one that springs to mind as likely being even more difficult is the matter
of damaged
nuclear pore proteins in long - lived cells»
It will be one
of the hardest forms
of damage to repair via rejuvenation biotechnology; the only one that springs to mind as likely being even more difficult is the matter
of damaged
nuclear pore proteins in long - lived cells, single molecules that might be as old as you are, doing the same job for an entire human life span.
The Ellenberg group studies cell division and
nuclear organisation, focusing on chromosome organisation, the formation and segregation
of mitotic chromosomes, as well as
nuclear pore complex structure and assembly.
We also determined the positions
of various
nuclear pore complex (NPC) components and directly resolved the ring - like structure
of the NPC, combining stochastic super-resolution microscopy with single particle averaging.
Thankfully, the research carried out identified a part
of a protein that if absent, would stop the HSV from entering through the
nuclear pore.
The problem is not that such people do not exist in the various private sector or governmental
nuclear energy institutions — indeed they do exist, but they do not permeate every
pore of the institution.
of radioactive wastes, and non-radioactive wastes from
nuclear facilities S13 Hydro energy S14 Solar energy S15 Geothermal energy S16 Tidal and wave power S17 Wind energy S20 Fossil - fueled power plants S21 Specific
nuclear reactors and associated plants /
of pores, well formed grains and boundaries and good mechanical properties were obtained.