They ended up with
all of the nucleobases that make up RNA and DNA.
All the genetic information of modern life is stored in DNA as sequences
of nucleobases.
However, formation
of nucleobases from inorganic compounds available on prebiotic Earth had been considered to be difficult.
Pursuing the origins specifically of RNA, the close chemical relative of DNA, a research team led by Nicholas Hud, a professor in the School of Chemistry and Biochemistry at the Georgia Institute of Technology and director of the CCE, worked with a pair of potential chemical ancestors
of the nucleobases of RNA.
They found the formation of a far larger variety of life's building blocks, including two kinds
of nucleobases and nine kinds of proteinogenic amino acids.
With precise analysis of the products recovered after impacts, the team found the formation
of nucleobases and amino acids from inorganic compounds.
«However, we know so little about how life began that we should not use the stability
of nucleobases to constrain our models of Earth's temperature.»
Those peaks corresponded to seven different amino acids and 11 types
of nucleobases.
Not exact matches
Beyond that, it's been thirty + years since amino acids were discovered in fallen asteroids, and just recently they've found two
of the four
nucleobases that form the rungs
of the DNA double helix.
«Several unusual
nucleobases have been found in the genomes
of stem cells, which are produced by targeted chemical modification
of the known building blocks
of DNA.
Alan Schwartz, a biochemist at the University
of Nijmegen in the Netherlands, took the idea further when he showed in 1982 that frozen cyanide, in the presence
of ammonia, can form a
nucleobase called adenine.
Over a quarter - century, the frozen ammonia - cyanide blend had coalesced into the molecules
of life:
nucleobases, the building blocks
of RNA and DNA, and amino acids, the building blocks
of proteins.
Many
of Rick Pierson's comments are correct, in particular his identification
of what scientists call the water problem: the fact that the reaction
of a phosphate with ribose and
nucleobases to form a nucleotide is energetically uphill in water.
Chemical analysis showed that the meteorite contains xanthine and uracil, substances called
nucleobases that are necessary for RNA and DNA to form their base pairs as part
of their replication process.
Martins found the answer by extracting two molecules from the meteorite: uracil, a
nucleobase found in RNA, and xanthine, an intermediate in the synthesis
of DNA and RNA.
Earlier researchers had detected subunits
of DNA and RNA, called
nucleobases, in the meteorite.
The work «nicely correlates the Late Heavy Bombardment and the energy that it delivered to Earth with the formation
of RNA and DNA
nucleobases from formamide», says Steven Benner at the Foundation For Applied Molecular Evolution in Gainesville, Florida.
Figuring out how adenine and uracil (
nucleobases found in RNA today) combined with the sugar ribose (corresponding to the «R» in RNA) could answer one
of the great questions
of chemical evolution.
Nicholas Hud holds up Uracil, on the right, a
nucleobase of RNA.
DNA sequencing and genome mapping can thus be compared to dividing a very long text into lots
of small pieces that are read separately — letter by letter, or more exactly:
nucleobase per
nucleobase.
The basis for this observation is that the genomes
of all organisms are written in an «alphabet» that consists
of only four
nucleobase molecules: adenine (A), thymine (T), guanine (G) and cytosine (C).
base (in genetics) A shortened version
of the term
nucleobase.
While much
of the past work with DNA analogs such as PNA has focused on
nucleobases already anchored to their backbone units, Ghadiri had the idea
of working with simpler building blocks.