Sentences with phrase «of nucleolar»
BAZ2A is an essential component of the nucleolar remodeling complex (NoRC), which mediates recruitment of histone modifyine enzymes and DNA methylase involved in the silencing of ribosomal RNA transcription by RNA polymerase I. BAZ2B is believed to be involved in regulating nucleosome mobilization along linear DNA.
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The investigators uncovered a number of host factors that were deactivated by early viral proteins and identified a subgroup of nucleolar proteins that aid virus replication.
The paper is important, says developmental biologist Jirí Kanka at the Institute for Animal Physiology and Genetics in Libêchov, Czech Republic, because it shows the contribution of a single protein to the complex process of nucleolar disassembly.