Sentences with phrase «of nucleotide substitution»

Variation in the pattern of nucleotide substitution across sites.

Variation in the pattern of nucleotide substitution across sites Huelsenbeck, J. P. and R. Nielsen.

This may partly explain why the rate of nucleotide substitution is generally higher in mtDNA than in nuclear DNA.

Phylogenetic inference was carried out for each supermatrix using Exascale Maximum Likelihood (ExaML) v1.0.2 (sco.h-its.org/exelixis/software.html) under the «GAMMA» model of nucleotide substitutions and the starting trees generated above.

Moreover, given that point mutations are acquired through DNA copy - errors (and / or failure of DNA damage repair mechanisms) during replication, preferentially within the paternal germline, a detailed knowledge of these basic biological processes is key to understanding the patterns of nucleotide substitutions.

Not exact matches

We have determined additional full - length sequences from two clusters of imported EBOV infections into Mali, and we show that the nucleotide substitution rate (1.3 × 10 — 3 substitutions per site per year) is consistent with rates observed in Central African outbreaks.

(A) Unrooted phylogenetic tree of EBOV samples; each major clade corresponds to a distinct outbreak (scale bar = nucleotide substitutions per site).

Mutation means a change in DNA through, for example, substitution or insertion [of nucleotides].

But the exact causes of the vast majority of autism - related disorders remain a mystery: classic genetic studies, which tie the ailment to single nucleotide polymorphisms (SNPs — deletions, additions or substitutions of one unit in the genetic code), have returned a number of different markers with very few well - replicated candidates.

During genome evolution the spectrum of possible mutations is extremely broad, ranging from single nucleotide substitutions all the way up to Mb - sized rearrangements and translocations.

Nucleotide substitutions introduced into the regulatory elements of p21waf1 / cip1 promoter region in mutant constructs are shown in boldface and underlined.

To determine if positive selection has played a role in Boule evolution, we compared the ratio of the rate of nucleotide changes that result in a non-synonymous amino acid substitution (Ka) to the rate of nucleotide changes that cause a synonymous amino acid substitution (Ks).

This section invites manuscripts describing (a) Linkage, association, substitution or positional mapping and epigenetic studies in any species; (b) Validation studies of candidate genes using genetically - engineered mutant model organisms; (c) Studies focused on epistatis and gene - environment interactions; (d) Analysis of the functional implications of genomic sequence variation and aim to attach physiological or pharmacogenomic relevance to alterations in genes or proteins; (e) Studies of DNA copy number variants, non-coding RNA, genome deletions, insertions, duplications and other single nucleotide polymorphisms and their relevance to physiology or pharmacology in humans or model organisms, in vitro or in vivo; and (f) Theoretical approaches to analysis of sequence variation.

These comprehensive assays are capable of detecting single nucleotide substitutions, insertions, deletions and gene rearrangements.

With these aspects in mind, I would certainly want to see this used in mutations with single nucleotide substitutions (variants) that characterize most ADAD mutations, and like to see the further development of the embryos as it relates to normal development after the normal sequence is introduced.

This led to the eventual identification of a single nucleotide substitution in the second codon of a previously unknown gene that is now known to be the cause of PRCD in at least 18 different breeds [23].