Not exact matches
Obese patients were accordingly advised to replace fats and sweets
with a more prudent dietary pattern characterized by a high intake
of fruit, vegetables, whole grains, poultry, and fish (70, 71).
To qualify,
patients must be an acceptable surgical risk and be defined as either severely
obese with a BMI
of 40 or greater or have a BMI
of 35 or greater
with at least one related condition: diabetes, obstructive sleep apnea, obesity - related cardiomyopathy or heart muscle disease or severe joint disease.
The Northwestern study reported
patients with eczema had 54 percent higher odds
of being morbidly
obese, 48 percent higher odds
of hypertension, up to 93 percent higher odds
of having pre-diabetes and up to 42 percent higher odds
of having diabetes.
The review found that 19.3 percent
of the
patients diagnosed
with a depressive disorder reported lower back pain, as did 16.75 percent
of patients diagnosed as
obese (a body mass index, or BMI, > 30kg / m ²), 16.53 percent
of the
patients diagnosed
with nicotine dependence, and 14.66 percent
with reported alcohol abuse.
The team found that
obese people
with kidney cancer had a 53 % lower risk
of dying from renal - cell carcinoma than
patients who were normal weight2.
Both groups
of animals were equivalent to 55 - to 60 - year - old morbidly
obese patients with uncontrolled diabetes, the most difficult population to treat.
Egg recipients, however, were
of varying body weights, and divided into four groups: lean
with BMI below 20 kg / m2 (1458
patients, 15.2 %), normal
with BMI 20 - 24.9 kg / m2 (5706
patients, 59.5 %), overweight
with BMI 25 - 29.9 kg / m2 (1770
patients, 18.5 %), and
obese with BMI > = 30 kg / m2 (653
patients, 6.8 %).
«Our study emphasizes the importance
of individualized therapy strategies and lifestyle interventions in order to prevent structural knee joint degeneration as early as possible in
obese and overweight
patients at risk for osteoarthritis or
with symptomatic osteoarthritis,» Dr. Gersing said.
The results suggest that the risk
of revision surgery and most other complications
of shoulder arthroplasty increases along
with BMI in
obese patients.
Using available databases reflecting the utilization
of health services in California, Florida and Nebraska — all three
of which give access to deidentified information on individual
patients — the research team identified 2,261
obese patients with asthma who underwent bariatric surgery from 2007 to 2009 and for whom information covering the two years before and after their surgery was available.
A study led by Massachusetts General Hospital (MGH) investigators suggests that bariatric surgery can significantly reduce the risk
of asthma attacks — also called exacerbations — in
obese patients with asthma.
«We found that, in
obese patients with asthma, the risk
of emergency department visits and hospitalizations for asthma exacerbations decreased by half in the two years after bariatric surgery,» says Kohei Hasegawa, MD, MPH, MGH Department
of Emergency Medicine, the lead author
of the study.
«The question is what underlying mechanism causes this advantage in
obese men, and can we take advantage
of it to improve outcomes in
patients with melanoma?»
Obese patients with metastatic melanoma who are treated
with targeted or immune therapies live significantly longer than those
with a normal body mass index (BMI), investigators report in a study published in Lancet Oncology
of 1,918
patients in six independent clinical cohorts.
The treated rodents were not only fatter but also suffered elevated levels
of fasting insulin, and alterations in genes related to liver regeneration and detoxification — effects consistent
with metabolic disorders in
obese patients.
Although we often associate fatty liver disease
with obese patients, these results suggest that possible signs
of liver disease secondary to NAFLD in lean
patients should be taken very seriously,» said Dr. Angulo.
Concentrations
of hs - TnI were compared between 74 morbidly
obese patients who had a type
of bariatric surgery called Roux - en - Y gastric bypass, 62 morbidly
obese patients who exercised and restricted their calorie intake, and a control group
of 30 people
with normal weight.
The average
patient age was 65.5 years old, and 61 percent
of patients were
obese with a Body Mass Index (BMI)
of 33 kg / m ².
In addition to Dr. Aminian, study authors
of the abstract entitled, «A Nationwide Safety Analysis
of Bariatric Surgery in Nonmorbidly
Obese Patients with Type 2 Diabetes,» include John Kirwan, PhD; Bartolome Burguera, MD, PhD; Stacy Brethauer, MD; and Philip Schauer, MD, all from Cleveland Clinic.
«We have an application
with the NIH [National Institutes
of Health] to test this in
obese patients that exhibit bingelike behavior.»
The Inventory
of Nocturnal Eating, a self - report questionnaire addressing nocturnal eating and sleep disturbance, was administered to out -
patients (N = 126) and in -
patients (N = 24)
with eating disorders,
obese subjects (N = 126) in a trial
of an anorexic agent, depressed subjects (N = 207) in an antidepressant trial, and an unselected group (N = 217)
of college students.
«While there is no single ideal bariatric procedure that can be applied to all severely
obese patients, we have generally recommended the duodenal switch for those
with a BMI greater than 50,» said study author Vivek Prachand, MD, assistant professor
of surgery at the University
of Chicago.
As demonstrated by a recent metaanalysis
of prospective cohort studies even
obese men and women
with normal cardiometabolic clustering had a 4-fold higher relative risk
of developing T2DM, although this risk was only half
of that
of metabolically unhealthy
obese patients regardless
of sex differences in the progression toward T2DM (40).
For
patients with stage II or stage III colon cancer, the difference in long - term survival for leaner
patients compared to those
with a body mass index (BMI)
of 35 or greater — which physicians refer to as «very
obese» — was comparable to the difference between those who had surgery followed by chemotherapy and those who had only surgery.
Among men who received treatment for the potentially deadly cancer,
obese patients lived an average
of 47 percent longer than those
with a healthy body weight, researchers found.
«The question is, what underlying mechanism causes this advantage in
obese men, and can we take advantage
of it to improve outcomes in
patients with melanoma?»
As a doctor
of physical therapy, gut health provides insight into why my
patients (especially overweight or
obese patients) develop osteoarthritis in non-weight-bearing joints like the wrist, by pointing to a problem
with systemic inflammation.
The company recently announced that in one trial
of 505
obese people
with type 2 diabetes, 45 %
of patients taking Contrave32 lost at least 5 %
of their body weight compared to
patients in a placebo group; only 19 %
of the placebo group lost at least 5 %
of their body weight.
A study in the Annals
of Internal Medicine found that
obese patients with type - 2 diabetes who went keto for just two weeks improved insulin sensitivity by 75 %.
Data from a study on the characteristics
of CKD
patients, 55 percent
of whom are male, found that typically, 18 percent
of CKD
patients are
of normal weight (BMI < 25), 29 percent are overweight (BMI 25 - 30) and 53 percent are
obese (BMI > 30), 84 percent have hypertension and 42 percent have diabetes.8 Obesity is a risk factor for CKD and hypertension, and is associated
with increased sodium excretion.
In 2005, in the Annals
of Internal Medicine, the article «Effect
of a Low - Carbohydrate Diet on Appetite, Blood Glucose Levels, and Insulin Resistance in
Obese Patients with Type 2 Diabetes» showed that 2 weeks
of a very low carbohydrate diet
with no caloric restrictions reduced appetite and body weight.
Studies
of bariatric surgery and weight loss have conclusively shown that type 2 diabetes is reversible and therefore the beta function can be recovered even in massively
obese patients with decades
of disease.
Thus, replacement
with timed - released T3 preparations to normalize the reduced intracellular T3 levels is appropriate in such
patients despite so - called «normal» levels while, on the contrary, T4 - only preparations do not address the physiologic abnormalities
of such
patients and should be considered inappropriate replacement for
obese patients or those
with insulin resistance, leptin resistance, or diabetes, as they do not address the physiologic abnormalities in this group.
published the results
of their investigation
of the impact
of supplemental T3 on cardiovascular risk in
obese patients to partially reverse the reduced T4 to T3 conversion seen
with obesity (53).
Total fasting was compared
with a 300 kcal / day very low calorie diet providing 56 g protein and 12 g carbs in 14 healthy
obese patients, selected as matched pairs, over a period
of 28 days.
In one study when researchers in Czechoslovakia treated 60
obese patients with MCT oil they concluded that MCTs offered a number
of benefits, stating, «Administration
of... medium - chain fatty acids can... improve the long - term success
of diet therapy
of obese patients.»
Case in point: I work
with a functional med doc who, upon being asked by an
obese patient with metabolic syndrome whether she should drink a can
of diet pop or regular pop (because she absolutely had to have just one a day), the doc strongly recommeded the regular pop.
Zelman, aware
of the animal data, spent the next few years tracking down twenty other
obese, non-alcoholic
patients with evidence
of liver disease.
In rodents, ketogenic diets reduce reactive oxygen species in the brain34 and reduce central inflammation and reactive oxygen species in a model
of multiple sclerosis.35 Two clinical papers have found that ketogenic diet feeding
of 12 weeks to 6 months reduced signs
of liver inflammation in
obese patients with nonalcoholic fatty liver disease (in addition to improving various other physiological and biochemical variables).36, 37 Unfortunately, basic research into non-alcoholic fatty liver disease has been hampered by species differences between mice and humans in their hepatic reaction to ketogenic diets.38
When a rigorous gluten free diet was followed, it was seen that while those
patients with low BMI attained the normal range, 50 %
of those who were
obese also attained normal BMI.
All we have to go on is preclinical data in mice (and many
of these mice are
obese and raised in crowded cages6), and we must remember this, especially
with patients and their families who are at wit's end because they are unable to effectively follow the diet.
«Oral ingestion
of a hydrolyzed gelatin meal in subjects
with normal weight and in
obese patients: Postprandial effect on circulating gut peptides, glucose and insulin.»
Effect
of a low - carbohydrate diet on appetite, blood glucose levels, and insulin resistance in
obese patients with type 2 diabetes
These results concur
with studies on human
patients, which report a decrease in insulin sensitivity
of between 44 and 72 % in
obese subjects compared
with normal - weight control subjects (34 — 37).
The rate
of progression to absolute insulin deficiency has not been studied in dogs, but epidemiological factors closely match those
of human
patients with the LADA form
of type 1 diabetes, who are usually not
obese and tend to be middle aged and older.
There is also no doubt that a few
patients, specifically very
obese or giant breed dogs and animals
with severe restrictions to the functioning
of their other limbs, may have greater difficulty in adapting after amputation.
The current study examined the psychometric properties
of the Yale Food Addiction Scale (YFAS) in
obese patients with binge eating disorder (BED) and explored its association
with measures
of eating disorder and associated psychopathology.