Sentences with phrase «of octamer»

These constructs are activated by Oct4 monomers (6xW) or homodimers in one of two distinct configurations (PORE and MORE, due to different arrangements of the octamer sequences within these motifs, see Discussion for details [10], [26]-RRB-.

Thus, depending on arrangements of the octamer motif, and presence of DNA motifs for additional transcription factors, Oct4 can form heterodimers with multiple partners or homodimers in one of several unique conformations [17].

Center cells lost the expression of octamer - binding transcription factor 4 (OCT4) and epithelial cadherin (E-cadherin) faster than perimeter cells, which are critical to the development of heart tissue.

Alterations of the octamer motif increased enhancer activity.

Not exact matches

Most of the affected residues are in four clusters, in sequences homologous to the octamer 5 «CAGGTGGC 3» (C, cytosine; A, adenine; G. guanine; T, thymine).

The fusion protein produced on inducing a lysogen of one phage bound to a monomeric octamer probe.

Cloning of a lymphoid - specific cDNA encoding a protein binding the regulatory octamer DNA motif

An octamer DNA sequence plays a critical role in directing transcription of immunoglobulin genes in B lymphocytes.

A new technique of direct binding of radioactive DNA was used to screen a complementary DNA expression library from the BJAB cell line in lambda gt11 phage to derive molecular cDNA clones representing a putative B lymphocyte - specific octamer binding protein.

Intriguingly, in contrast to the canonical nucleosome (where 147 bp of DNA are wrapped around the histone octamer), only the central 121 bp were visible, suggesting flexible CENP - A nucleosomal ends.

Oct4 contains two distinct DNA binding domains (the POUH and POUS domains, each of which can bind to half of the DNA octamer motif independently of the other) which are separated by a flexible linker [39]; this in turn allows for substantial leeway in arrangement of these domains in relation to each other [17].

Oct4 has two distinct DNA binding domains which independently bind half - sites of the canonical octamer motif.