«Spatial perception
of odorants in cockroaches.»
The study describes the first neural architecture capable of encoding the spatial location
of odorants.
The nasal airflow measurement and the presentation
of odorants were done using a modified pediatric nasal cannula and a custom built olfactometer.
For the first time is has been demonstrated that measurements
of odorants in the air may be an alternative to dynamic olfactometry that can be applied for measuring odour from pig houses and the effects of odour abatement technologies.
By means of the new technique the highly variable sensory response from the human nose may be predicted based on the more precise chemical measurement
of odorants.
It would be even better if we were able to carry out the analyses on location at the pig farm; this way you can avoid having to bring bags of air back to the laboratory at the risk of «running out of air,» i.e. losing
some of the odorants.
Usually, it takes a nose to smell, but now — for the first time — scientists have developed a convincing model able to measure odours from pig farms by means of precise measurements of the content
of odorants in the atmosphere.
The model is based on measurements
of odorants by means of the analytical technique PTR - MS.
«If the ointment is applied over the heart, the concentration
of odorants that penetrate through the skin might be sufficient to have an effect on the heart; there are some hints of that,» says Hatt.
For example, based on the perception of the hundreds
of odorant molecules found in coffee, the piriform cortex would be able to recognize a single odor, that of coffee.
Beta - adrenergic receptor kinase - 2 and beta - arrestin - 2 as mediators
of odorant - induced desensitization
In 2007 Turin (who is now chief technical officer
of the odorant - designing company Flexitral in Chantilly, Virginia) and his hypothesis received support from a paper by four physicists at University College London.
Via the position of the receptors on the antennae — which can grow to a length of four to five centimetres, which is the size of the cockroach's body — the insects obtain information about the spatial position
of an odorant.
Transcriptomic and Proteomic Profiling Revealed High Proportions
of Odorant Binding and Antimicrobial Defense Proteins in Olfactory Tissues of the House Mouse — Barbora Kuntová — Frontiers in Genetics
To first order, deuteration should therefore have little or no effect on the smell character
of an odorant recognized by shape, whereas deuterated isotopomers should smell different if a vibrational mechanism is involved.
Not exact matches
Turin says the strongest tests
of his theory so far come from studies in which researchers replace an
odorant atom with an isotope
of that atom, which has a slightly different weight and changes the molecule's frequency
of vibration.
Turin's more controversial theory, put forth in 1996 and now the subject
of two popular books, holds instead that
odorant receptors sense the way a molecule's atoms jiggle.
In the case
of β - ionone, the smell associated with violets, McRae and colleagues managed to pinpoint the exact mutation (a change in the DNA sequence) in the
odorant receptor gene OR5A1 that underlies the sensitivity to smell the compound and to perceive it as a floral note — people who are less good at smelling β - ionone also describe the smell differently, as sour or pungent, and are less likely to find it pleasant.
The smells
of these four
odorants are familiar, for those who can smell them (though their names may not be): malt (isobutyraldehyde), apple (β - damascenone), blue cheese (2 - heptanone), and β - ionone, which smells floral to some people and is particularly abundant in violets.
This latest smell prediction effort began with a recent study by olfactory researcher Leslie Vosshall and colleagues at The Rockefeller University in New York City, in which 49 volunteers rated the smell
of 476 vials
of pure
odorants.
The
odorant receptor molecules sit on the surface
of sensory nerve cells in our nose.
It reduced the pulse frequency
of the cultivated mini hearts; the higher the
odorant concentration, the more significant the reduction.
The team performed a series
of tests, including comparative Aroma Extract Dilution Analysis (AEDA) as well as sensory evaluation by a panel
of 10 participants who had received extensive training in identifying different wine
odorants.
Paying attention to the fact that each olfactory sensory neuron (OSN) expresses an OR, Shun «ichi Kuroda, Professor and Nobuo Yoshimoto, Specially Appointed Associate Professor at the Department
of Biomolecular Science and Reaction, The Institute
of Scientific and Industrial Research, Osaka University in cooperation with Masato Suzuki, Chief Researcher, Advanced Research Division, Panasonic Corporation made a system in which OSNs from mice were applied to a microchamber array on a microscope slide and fluorescence was yielded when ORs responded to
odorants.
Like OSNs, animal cells expressing ORs responded to the
odorant of interest, emitting fluorescence.
Both methods have advantages and disadvantages, but the optimum method would be to be able to quantify the connection between the smell that the human nose experiences and the actual, measured amount
of specific
odorants in the air.
The fear
of obnoxious
odorants may also be a hindrance if pig farmers want to expand their herds.
The scientists also aimed to identify significant
odorants in order to assess odour emission from the pig facilities as well as the effect
of technologies that reduce odour problems.
This achievement will enable quick and easy exhaustive analysis
of ORs responding to specific
odorants, which previously required a great deal
of time and effort.
14 Penn State engineers are trying to design an artificial sniffer based on the fluid mechanics and
odorant transport
of the canine nose.
«New method for exhaustively isolating olfactory receptors responding to specific
odorants: Step toward the elucidation
of a mechanism for recognizing
odorants in mammals.»
A research group led by Osaka University and Panasonic Corporation developed a method for making a prompt, exhaustive isolation
of olfactory receptors (ORs) responding to the
odorant of interest.
A side effect
of losing PRMT - 5 in C. elegans is a heightened sense
of smell: In the worms, dopamine signaling acts as a brake or check on the sensory system's response to
odorants.
Christine Mißbach, first author
of the study, analyzed the active genes in the insect antennae where the olfactory receptors are located and describes her discovery this way: «Astonishingly, the firebrat, which is more closely related to flying insects, employs several co-receptors, while the
odorant receptors themselves are absent.»
Despite these miniscule variations, the flies showed a consistent preference for one arm
of the maze over the other, the team reports online today in the Proceedings
of the National Academy
of Sciences, suggesting that the flies could tell the difference between the
odorants.
Most scents are composed
of many
odorants; a whiff
of chocolate, for example, is made up
of hundreds
of different odor molecules.
When Vosshall's team crunched these numbers, extrapolating how many different combinations
of the 128
odorants an average person could differentiate, they arrived at an average
of 1 trillion smells.
In addition, each foodstuff has its own odor code comprised
of a core group
of between just 3 and 40
of the 230 key
odorants — in specific concentrations.
Then, as now, the prevailing notion was that the sensation
of different smells is triggered when molecules called
odorants fit into receptors in our nostrils like three - dimensional puzzle pieces snapping into place.
The findings also lay the scientific groundwork for the next generation
of aroma products, which use the potential
of optimized biosynthetic pathways in plants for industrial - scale production
of high - quality food
odorants.
«A combination
of between just few key
odorants creates an authentic perception
of odors.
The notoriously strong winds at Aliso Canyon carried the natural gas and its added
odorant to the nearby Porter Ranch neighborhood, leading to thousands
of families evacuating their homes.
What is really happening, Turin posited, is that the approximately 350 types
of human smell receptors perform an act
of quantum tunneling when a new
odorant enters the nostril and reaches the olfactory nerve.
Each odor - detecting neuron (referred to as olfactory sensory neuron from here on), chooses a single
odorant receptor gene from a fairly large number
of options that are split into class I (fish - like) and class II (terrestrial - specific)
odorant receptors.
As an
odorant approaches, electrons released from one side
of a receptor quantum - mechanically tunnel through the
odorant to the opposite side
of the receptor.
This latest
odorant mapping will also enable more precise natural simulation
of odors.
The study «A long - range cis - regulatory element for class I
odorant receptor genes» published in Nature Communications was a collaborative effort between Tokyo Tech, the University
of Tokyo, Nihon BioData Corporation and RIKEN Brain Science Institute.
They were surprised to find that the almost unlimited variety
of food smells is based on 230 key
odorants.
After the
odorant attaches to one
of the nerve's receptors, electrons from that receptor tunnel through the
odorant, jiggling it back and forth.
This study demonstrates, for the first time, that the mammary pheromone helps pups learn other
odorants, says neuropsychologist Peter Brunjes
of University
of Virginia in Charlottesville.