Sentences with phrase «of oestrogen receptors»

Breast Cancer Care comment on claims that long - term use of Tamoxifen may increase proportion of oestrogen receptor (ER) negative cancers which develop in the opposite breast

«The study shows that long - term use of Tamoxifen does not increase incidence of breast cancer in the opposite breast, but it may increase the proportion of oestrogen receptor negative cancers.

By using a range of tissue stains, they were able to assess levels of oestrogen receptor (ER), progesterone receptor (PR) and HER2 — human epidermal growth factor — in order to divide the samples into four subtypes.

«A better understanding of the biological basis of oestrogen receptor negative breast cancer may lead to more effective preventive interventions and treatments.»

Not exact matches

Because of a quirk of evolution, these plant chemicals are close enough to the natural hormone's shape to bind to the oestrogen receptors on cells in the human body.

Around 70 % of all cases of breast cancer are oestrogen - receptor positive, meaning that the cancer cells have a particular protein (known as a receptor) that responds to the female sex hormone oestrogen, enabling the tumour to grow.

Of these variants, reported today in the journals Nature and Nature Genetics, 65 are common variants that predispose to breast cancer and a further seven predispose specifically to oestrogen - receptor negative breast cancer - the subset of cases that do not respond to hormonal therapies, such as the drug tamoxifeOf these variants, reported today in the journals Nature and Nature Genetics, 65 are common variants that predispose to breast cancer and a further seven predispose specifically to oestrogen - receptor negative breast cancer - the subset of cases that do not respond to hormonal therapies, such as the drug tamoxifeof cases that do not respond to hormonal therapies, such as the drug tamoxifen.

«We used different groups of mice, in which either the oestrogen receptor or RANKL was inactivated in hematopoietic cells or in mesenchymal cells, to be able to identify the target cells of the hormone.

The data included information on the age of diagnosis, region of residence, deprivation, ethnicity, tumour size, grade, oestrogen receptor status (ER), Herceptin receptor status (HER2), and whether or not the cancer had spread to the lymph nodes.

A lack of oestrogen or the corresponding cell receptors where it can bind results in the overproduction of RANKL, which triggers a variety of pathological bone changes.

It doesn't just bind to the main oestrogen receptor, but also to poorly understood variants of it, and has an anti-androgen effect.

One third of the target genes for which they had patient data - 32 out of 97 - were also linked to survival in women with oestrogen receptor - positive breast cancer, suggesting they play an important role in the disease.

Previous large - scale genetics studies have implicated 14 of the 110 genes as playing a role in breast cancer risk, such as the oestrogen receptor gene ESR1, showing that Capture Hi - C is an effective tool for picking up risk genes.

In addition to a range of antibodies, Abcam offers over 4,000 pharmacological tools covering receptor agonists and antagonists, like Tamoxifen Citrate and oestrogen receptor, which is also used in the control of gene expression.

Thesis title: «Predicting the risk of recurrence in oestrogen - receptor positive breast cancer: how precise need we be?»

A role for the androgen metabolite, 5alpha - androstane - 3beta, 17 beta - diol, in modulating oestrogen receptor beta - mediated regulation of hormonal stress reactivity..

Broccoli has a very useful bioflavonoid called kaempferol, which prevents the binding of oestrogen to its receptors, and stops the development of breast cancer.

(4) The demonstration of a melatonin receptor in human ovary suggests a direct influence of this hormone on the ovarian function, and possibly oestrogen production.