Sentences with phrase «of old mice»

Those antibodies also seemed to help the brains of older mice that had aged naturally, the team found.

A protein in blood can repair age - related damage in the brains and muscles of old mice, returning them to a more youthful state.

Thanks to cutting - edge microscopy techniques, they observed for the first time a specific defect in the eggs of older mice.

The team also joined together 12 pairs of old mice and 10 pairs of young mice, as controls.

Likewise, young blood can restore the memory and energy of older mice.

The neurons of old mice pumping young blood appeared to grow new places where they could connect with other neurons.

The most exciting aspect of this experiment was the recovery of older mice that had already developed symptoms.

The study showed that the organs of the older mice became healthier, thanks to the presence of the younger blood.

Never a fan of the old mouse system, this unfortunately isn't an improvement.

For this reason, our study suggests accumulation of SAMs in tissues of old mice may have been erroneously interpreted as accumulation of senescent cells.

In 2013, researchers reported that they were able to cure hypertrophy in mice by surgically merging the circulatory systems of an older mouse with a younger mouse.

In 2012, Research published by Dr Sinclair of Harvard stunned researchers by showing that short term supplementation with Nicotinamide Mono - Nucleotide (NMN) reversed many aspects of aging, making the cells of old mice resemble those of much younger mice, and greatly improving their health.

Multiple groups of scientists have shown that adding the blood of older mice to younger animals» bodies makes them sluggish, weaker, and more forgetful.

The idea that an infusion of young blood could regenerate ageing bodies was explored several years ago when the circulatory systems of old mice were physically connected to those of young animals, as if they were conjoined twins.

Tilly and his team examined the ovaries of old mice in which the Bax gene had been «knocked out» in early embryos before they developed.

This rejuvenated the stem cells in the bone marrow of the older mice that replenish their blood, and led to a wave of studies comparing the blood of old and young mice to try and identify the youth - giving substance.

As these studies were being done, Malaspina asked Jay Gingrich, a psychiatrist and neuroscientist at Columbia who works with mice, whether he could look for the same effect in the offspring of older mice.

In addition to improving endothelial function, the MitoQ treatment increased levels of nitric oxide, reduced oxidative stress and improved the health of the mitochondria in the arteries of old mice.

The health of the older mice improved, while the younger ones deteriorated.

To measure the differences in immune system function between the two groups of older mice, the researchers examined the lungs to assess damage, counted the number of bacteria in the lungs, and calculated the number of the white blood cells (neutrophils).

When the researchers added GnRH to the hypothalamuses of old mice, they saw that it promoted adult neurogenesis.

Using a surgical technique, the researchers introduced an experimental demyelinating injury in the spinal cord of an old mouse, creating small areas of myelin loss, and then exposed those areas to cells found the blood of a young mouse.

Several studies in recent years have shown that treatment of old mice with PARP inhibitors or precursors to NAD + such as NMN can greatly improve health.

One study showed an average 5 % increase in the lifespan of old mice — even though supplementation did not begin until the mice were nearing the end of their natural lifespan (24 months).11

In 2005, Rando and his colleagues published a study in Nature showing that stem cells in several tissues of older mice, including muscle, seemed to act younger after continued exposure to younger mice's blood.

Three weeks later, the brain cells of the older mice had 20 per cent more dendrites, the spines that relay messages between neurons, than mice given a placebo.

Five years ago, researchers at the Perelman School of Medicine, University of Pennsylvania, showed that the UPR is an adaptive response to stress induced by sleep deprivation and is impaired in the brains of old mice.

One substance in the blood of old mice, a protein called Beta ‑ 2 ‑ microglobulin, or B2M, seemed to prematurely age the young ones, Villeda and colleagues reported last year in Nature Medicine (SN: 8/8/15, p. 10).

When the researchers injected the protein into the heart muscle of old mice, it became «younger» — thinner and better able to pump blood.

Members of the Villeda and Wyss - Coray labs first showed that B2M levels steadily rise with age in mice, and are also higher in young mice in which the circulatory system is joined to that of an older mouse.

In 2014, highly publicized work in the laboratories of Villeda and Tony Wyss - Coray, PhD, professor of neurology at Stanford, showed that connecting the circulatory system of a young mouse to that of an old mouse could reverse the declines in learning ability that typically emerge as mice age.

The researchers harvested satellite cells from both healthy and injured muscle tissue of young mice and from healthy tissue of old mice; extracted these cells» DNA with the histone coatings intact; and used tagged antibodies targeting the different kinds of marks to find which spots on those histones were flagged with either «stop» or «go» signals.

But now that we know what kinds of changes occur as these cells age, we can ask which of these changes reverse themselves when an old cell goes back to becoming a young cell» — as appeared to be the case when tissues of older mice were exposed to blood from younger mice.

Then an experiment in 2005 found that young blood returned the liver and skeletal stem cells of old mice to a more youthful state, and work in 2012 discovered that young blood can reverse heart decline in old mice.

In the 1950s, in a Frankenstein - style process called parabiosis, scientists sewed the circulatory system of a young mouse to that of an old mouse.