Future work also will explore several paradoxical associations that relate the sensory and health - promoting aspects
of oleocanthal and ibuprofen.
The study authors applied different concentrations
of oleocanthal over three days to mouse brain cell cultures.
Not exact matches
«We're trying to further understand
oleocanthal's mechanism and maybe eventually try to find compounds that can work in the same way for drug development,» says Amal K. Kaddoumi, an assistant professor
of pharmaceutics at the University
of Louisiana at Monroe and one
of the paper's authors.
In both trials, levels
of two proteins that play major roles in transporting beta - amyloid out
of the brain as well as enzymes that degrade beta - amyloid increased significantly after administering
oleocanthal.
Oleocanthal is one
of several compounds that scientists have been working with to clear beta - amyloid from the brain.
But in 2005 scientists discovered that
oleocanthal — the naturally occurring compound that elicits a peppery, burning sensation in the back
of the throat — seemed to produce effects strikingly similar to those
of ibuprofen, which tamps down inflammation.
Compared with control groups, the mice that were given
oleocanthal showed significantly enhanced clearance and degradation
of the beta - amyloid peptides.
The current study, published in the Journal
of Neuroscience, extends those findings by identifying TRPA1 as the receptor that is activated by both
oleocanthal and ibuprofen.
Oleocanthal, the source
of olive oil's distinctive aftertaste, has been shown to have similar effects as ibuprofen.
Joining oleuropein as one
of the best researched compounds in olive oil is
oleocanthal.
Anti-inflammatory benefits
of virgin olive oil and the phenolic compound
oleocanthal.»
If oleuropein is the signature compound
of the olive leaf,
oleocanthal is the star
of olive oil; it has extremely promising anti-inflammatory properties
of its own.