Lurking within the mucus of the nose are the tips
of olfactory receptor cells.
Not exact matches
Physicist Marshall Stoneham and his colleagues at University College London report they have constructed a specific mechanism based on the properties
of so - called G - protein coupled
receptors, which project from
olfactory cells inside the nose.
The
olfactory system comprises six million to 10 million
receptor cells (
of which there are nearly 400 different types) and links to multiple brain structures and neural pathways, including those involved in memory, emotion and movement.
In the case
of SISSA's Neurobiology Laboratory, the focus was on the genes
of olfactory receptors which, surprisingly, are also present in the
cells that synthesise dopamine and that die in Parkinson's disease.
Together, the findings demonstrate that Ggamma13 is essential for mammals to smell odors and extend the current understanding
of how
olfactory receptor cells communicate information about odors to the brain.
Dogs can do that because their noses contain 900 different types
of olfactory receptors, chemical detectors in
cells that respond to many different kinds
of odor molecules in particular ways.
Kenyon
cells make up only about 4 %
of the entire fly brain and are extremely sensitive to inputs triggered by odors, in which only two connections between neurons, called synapses, separate them from the
receptor cells at the «front end»
of the
olfactory system.
In the cultivated
cells, the team detected a number
of typical
olfactory receptors.
Each
olfactory nerve
cell expresses just one
of these
olfactory genes to produce a
receptor that recognizes a related set
of odors.
The benefits
of using
olfactory receptor neuron samples to study psychiatric disorders and patient responsiveness include their similarity to brain neurons, the relatively easy biopsy procedure, and the potential for scientists to sample and compare
cells from the same patients throughout several different stages
of disease.
Additionally, most
of the cancer
cell lines expressing
olfactory receptors express the effectors necessary for OR - mediated signal transduction.
The mouse
olfactory sensory neuron (OSN) repertoire is composed
of 10 million
cells and each expresses one
olfactory receptor (OR) gene from a pool
of over 1000.