Sentences with phrase «of oligodendrocyte»

A key hold - up to applying this to humans has been the inability to isolate sufficient human cells of the oligodendrocyte lineage that could be used to myelinate the CNS.

Electrical stimulation of the medullary pyramid promotes proliferation and differentiation of oligodendrocyte progenitor cells in the corticospinal tract of the adult rat.

Regulation of store - operated and voltage - operated Ca2 + channels in the proliferation and death of oligodendrocyte precursor cells by golli proteins.

AST - OPC1 is comprised of oligodendrocyte progenitor cells manufactured from our pluripotent embryonic stem cell platform.

Modulation of Canonical Transient Receptor Potential Channel 1 in the Proliferation of Oligodendrocyte Precursor Cells by the Golli Products of the Myelin Basic Protein Gene.

B - 1a cells in meningeal space secrete natural antibodies, which promote the proliferation of oligodendrocyte precorsors.

Drosha degrades the messenger RNA for NFIB in the adult hippocampal stem cells and prevents the expression of this transcription factor which is necessary for the differentiation of oligodendrocytes and thus blocks their development and therefore biases differentiation towards neurons.

The team discovered that the B immune cells, called B - 1a cells, ensure that enough of these oligodendrocytes are available in the developing brain to support adequate myelination.

Autoimmune destruction of oligodendrocytes and their fatty contents gives rise to multiple sclerosis.

MS is a debilitating neurological disease caused by the destruction of oligodendrocytes, cells that build the myelin sheaths that surround the signal transmitting axons of neurons.

My laboratory studies the molecular mechanisms underlying the enhanced vulnerability of oligodendrocytes in neurodegenerative diseases such as Alzheimer's, including the age - related impairment of oligodendrocyte regeneration from glial progenitors.

ab16667 staining Ki67 (red) in transgenic mouse spinal cord tissue sections (depleted of oligodendrocytes) by Immunohistochemistry (PFA perfusion fixed frozen sections).

Not exact matches

It is an outgrowth of glial cells: Schwann cells supply the myelin for peripheral neurons while oligodendrocytes supply it to those of the central nervous system.

«There are currently no therapies which successfully reverse the damage seen in the more than 12,000 individuals who suffer a spinal cord injury each year in the United States alone,» says Dr. Richard G. Fessler, professor of neurological surgery at Rush University Medical Center and principal investigator for the Phase 1 clinical trial involving AST - OPC1 (oligodendrocyte progenitor cells).

Scores of laboratories at universities and in private industry are uncovering how to use these cells, which transform into neurons, astrocytes (the cells that regulate transmission of electrical impulses in the brain) and oligodendrocytes (which insulate nerve fibers with a fatty coating).

Normally, the cells Nobel used for the test would divide and give rise to a specialized type of cell in the central nervous system called an oligodendrocyte.

This type of stem cell, called an oligodendrocyte progenitor cell, is found in the brain and spinal cord.

If oligodendrocytes are making myelin in an environment with a lot of inflammation, as seen in MS patients, then the ER must work extra hard to make proteins to rebuild myelin and respond to surrounding inflammation.

A second potential drug, Sephin1, which is still in animal testing, keeps oligodendrocytes alive without the side effects of Guanabenz, Popko says.

The reason, say researchers: the hormone stimulates production of more oligodendrocyte stem cells, leading to more oligodendrocytes and therefore more myelin.

A third class of glia, known as Schwann cells and oligodendrocytes, form insulating sleeves around neurons to keep their electric signals from diffusing.

Image shows the complex shape of individual oligodendrocytes (OLs) and myelin in adult mice injected with tamoxifen.

Oligodendrocytes, the cells that are known to produce the myelin sheaths which enable saltatory conduction of action potentials along the myelinated axons, are modulators of signal transmission along neuronal connections (axons) and also promote neuronal survival by providing metabolic support.

The study introduced here focused on a population of support cells in the spinal cord that helps to protect surviving nerve cells (neurons) after injury: oligodendrocytes and their precursor cells.

Oligodendrocyte death, occurring after a spinal cord injury, activates a process called de-myelination that results first in damage to surviving neuronal connections and finally in death of the affected neurons.

«We experimentally depleted B cells from the brains of young mice and saw oligodendrocyte numbers drop significantly,» Tanabe adds.

Researchers at Osaka University found that B immune cells reside in the brains of developing mice, and play a key role in the myelination of neurons by oligodendrocytes.

Using live imaging in zebrafish to track oligodendrocytes in real time, researchers reporting in the June 24 issue of the Cell Press journal Developmental Cell discovered that individual oligodendrocytes coat neurons with myelin for only five hours after they are born.

The researchers hypothesize that guanabenz stimulates a protective cascade — because fewer oligodendrocytes die, less immune cells are recruited to the brain, which results in a decreased inflammatory response and preservation of myelin levels.

Brain tumors arise in the glia, or supportive cells, of the brain and now are classified by their histology — characteristics visible via microscopy — and their cell of origin, either astrocytes or oligodendrocytes.

To test the suitability of guanabenz as a potential treatment for MS, Popko and his team exposed cultured oligodendrocyte cells to interferon gamma — a molecule that increases inflammation — resulting in greatly increased myelin loss and cell death.

Investigators (Fumitaka Sato, PhD, et al) tested resveratrol in autoimmune and viral models of MS.. In the autoimmune model, experimental autoimmune encephalomyelitis (EAE) was induced in 6 - week - old mice using myelin oligodendrocyte glycoprotein (MOG) 35 - 55 peptide.

Dr. Lyons and his team used zebrafish to study the formation of myelin sheaths by oligodendrocytes because this laboratory animal is transparent at early stages of its development, which allows investigators to directly observe cells within the organism.

In vertebrates, the axons of many neurons are sheathed in myelin, which is formed by either of two types of glial cells: Schwann cells ensheathing peripheral neurons and oligodendrocytes insulating those of the central nervous system.

Most of these trials involve stem cell - derived neural progenitor cells, which can turn into several different types of brain or spinal cord cells, or oligodendrocyte progenitor cells, which create the myelin sheaths that insulate and protect nerve cells.

A1 bathwater also impaired the development of yet another class of non-neuron brain cells called oligodendrocytes — essentially fat - filled flapjacks that wrap themselves around nerve fibers, providing electrical insulation that speeds long - distance signal propagation.

The exosomes produced during environmental enrichment carry microRNAs — small pieces of genetic material — which appear to instruct immature cells in the brain to develop into myelin - making cells called oligodendrocytes.

Researchers at the Stanford University School of Medicine have succeeded in transforming skin cells directly into oligodendrocyte precursor cells, the cells that wrap nerve cells in the insulating myelin sheaths that help nerve signals propagate.

In the 6 September issue of The Lancet, the researchers suggest these genetic problems mean that oligodendrocytes, the cells that build the myelin sheaths, are dysfunctional in both diseases.

«These transplantation experiments confirmed that the reprogrammed cells indeed belong to cells of the intended brain regions and the progenitors produced the three major classes of neural cells: neurons, astrocytes and oligodendrocytes,» Zhang says.

Ten people will receive injections into the injury site of hESC - derived oligodendrocyte progenitor cells, which stimulate the growth of new and severed nerves and recoat damaged nerves with myelin.

Most of these trials involve stem cell — derived neural progenitor cells, which can turn into several different types of brain or spinal cord cells, or oligodendrocyte progenitor cells, which create the myelin sheaths that insulate and protect nerve cells.

That type of cell, an oligodendrocyte, insulates connections in the spinal cord, allowing them to conduct electricity.

Roy, K.; Murtie, J. C.; El - Khodor, B. F.; Edgar, N.; Sardi, S. P.; Hooks, B. M.; Benoit - Marand, M.; Chen, C.; Moore, H.; O'Donnell, P.; Brunner, D.; Corfas, G. Loss of erbB signaling in oligodendrocytes alters myelin and dopaminergic function, a potential mechanism for neuropsychiatric disorders.

Oligodendrocytes, a type of brain cell that plays a crucial role in diseases such as multiple sclerosis, are more diverse than have previously been thought, according to a new study led by Sten Linnarsson, Karolinska Institutet / SciLifeLab and Gonçalo Castelo - Branco, Karolinska Institutet.

If you are attending ISSCR 2017, you can attend the Asterias workshop, titled «Clinical Development of hESC - derived Oligodendrocyte Progenitors for the Treatment of Spinal Cord injury» on June 13, 2017 at 10:45 am.

There are multiple forms of MS and those afflicted with it can experience a range of symptoms but the underlying problem is damage to the insulation around the nerves, known as myelin, and the cells that produce it, known as oligodendrocytes.

Regulation of L - type Ca + + currents and process morphology in white matter oligodendrocyte precursor cells by golli - myelin proteins.

The researchers deliver a specific gene, which hitches a ride on a harmless virus, into the livers of mice, and once in the liver that gene codes for a protein called myelin oligodendrocyte glycoprotein.

At the International Society for Stem Cell Research 2017 Annual Meeting (June 14 - 17, 2017; Boston, USA), Asterias Biotherapeutics, Inc (CA, USA) will present new 9 - month efficacy and safety data from their ongoing SCiStar Phase I / IIa trial of human embryonic stem cell - derived oligodendrocyte progenitor cells.