Sentences with phrase «of oligomer»

I personally won't get excited about that until its practitioners can do it for large oligomeric proteins — which includes being able to predict what kind of oligomer any given macromolecule will form — and can also predict how a macromolecule's conformation changes when substrate or another macromolecule binds to it.

Inulin is composed of a mixture of oligomers and polymers of different degree of polymerisation.

Not exact matches

The nature of the bonds that stick the BPA molecules together doesn't allow the oligomers to revert to BPA.

TAML treatment at this pH caused BPA to assemble into larger units called oligomers, which clump together and precipitate out of the water.

According to Collins, the oligomers could be filtered and disposed of in a BPA water treatment facility.

To ensure the safety of the decontaminated water, including the oligomers, the researchers tested it with Tiered Protocol for Endocrine Disruption (TiPED) assays.

To investigate the nonlinear response of such plasmonic oligomers, the authors used a novel optical microscopy technique, which is equipped with polarization - structured beams.

The oligomers were fabricated at the University of Tübingen.

Joint research between Tampere University of Technology (TUT)(Finland) and University of Tübingen (Germany) has shown that carefully structured light and matching arrangements of metal nanostructures (so - called «plasmonic oligomers») can be combined to alter the properties of the generated light at the nanometer scale.

a) Plasmonic gold oligomer consisting of nanorods that are azimuthally arranged.

At the same time, researchers have found that much smaller protein clusters called oligomers — made of only a few copies of these proteins — can be highly toxic to motor neuron - like cells grown in the lab and thus are more likely to be the chief causes of brain - cell death in these diseases.

While these compounds did not reduce the amount of protein aggregates, they were found to reduce the protein's toxicity and to increase the stability of amyloid fibrils — a finding that lends further evidence to the theory that smaller assemblies of amyloid - beta known as oligomers, and not the fibrils themselves, are the toxic agents responsible for Alzheimer's symptoms.

In Ferris's lab, Hébrard conducted research on the formation of RNA oligomers — potential precursors of life — on clay minerals believed to be present on the primitive Earth.

The intervening sequence RNA excised from the ribosomal RNA precursor of Tetrahymena forms linear and circular oligomers when exposed to a heating - cooling treatment in vitro.

An oligomer of the Sec61 trimeric complex is thought to form the protein - conducting channel for protein transport across the endoplasmic reticulum.

The actin then takes any CPEB oligomers that are around and activates them, which makes more actin and causes the formation of a self - replicating prion of the CPEB.

Moreover, a funnel - shaped pore in the Sec61 oligomer aligned with the exit of a tunnel traversing the large ribosomal subunit, strongly suggesting that both structures function together in the translocation of proteins across the endoplasmic reticulum membrane.

In the brains of patients with Alzheimer's, amyloid peptides aggregate to form oligomers and plaques that are thought to be responsible for the disease symptoms.

But these days most neuroscientists agree that a tiny particle form of the same protein, called an oligomer, is the primary toxin in the illness.

When this happens, molecular nutrients can no longer move to where they are needed and the oligomers produce toxic effects leading to the eventual death of the brain cells.

Traditional methods for mapping HIV genetic material use long strings of these nucleotides, called oligomers, to find and bind to complementary strands of DNA or RNA in sample tissues.

«Non-invasive imaging by MRI of amyloid beta oligomers is a giant step forward towards diagnosis of this debilitating disease in its earliest form,» said Dravid, the Abraham Harris Professor of Materials Science and Engineering at the McCormick School of Engineering and Applied Science.

This new MRI probe technology is detecting something different from conventional technology: toxic amyloid beta oligomers instead of plaques, which occur at a stage of Alzheimer's when therapeutic intervention would be very late.

Data supports the notion that NU4 thus affords an excellent targeting antibody for the development of an amyloid beta oligomer - specific MRI probe that is distinct from currently available plaque probes.

Amyloid beta oligomers now are widely believed to be the culprit in the onset of Alzheimer's disease and subsequent memory loss.

The ability to detect amyloid beta oligomers, Klein said, is important for two reasons: amyloid beta oligomers are the toxins that damage neurons, and the oligomers are the first sign of trouble in the disease process, appearing before any other pathology.

Finally, that the onset of Alzheimer's disease coincides with immunosenescence, indicates that the immune system is constantly disposing of toxic oligomers while leaving plaque untouched, until due to its decline with age, the immune system is unable to remove those oligomers and the disease appears.

Summary: Many of the steps are known in using glyoxal with hydrogen peroxide to form dicarboxylic acids and chains of hydrocarbons, known as oligomers.

We discovered that levuglandins can greatly accelerate the oligomerization of amyloid beta and that the oligomers so formed are neurotoxic.

The CAMKK2 - AMPK kinase pathway mediates the synaptotoxic effects of Amyloid - beta oligomers through Tau phosphorylation on S262.

We are interested in the role of secretory chaperones in the biochemistry and cell biology of the neuron and have shown that two small secretory chaperones can block the formation of both Abeta oligomers and fibrils in vitro and neurootoxic aggregates in cell culture models.

Consistent with this, AFF 1 immunotherapy reduced the accumulation of AS neuropathology in neuronal bodies and neuropil at the cardinal sites for this LBD model (neocortex and hippocampus), and reduced the levels of AS dimers as well as oligomers in brain homogenates, while having no significant effect on monomeric AS.

Mairet - Coello G, Courchet J, Pieraut S, Courchet V, Maximov A and Polleux F. (2013) The CAMKK2 - AMPK Kinase Pathway Mediates the Synaptotoxic Effects of Abeta Oligomers through Tau Phosphorylation.

Furthermore, AMPK phosphorylates Tau on the KxGS - motif (S262) and expression of hTauS262A partially but significantly blocks the synaptotoxic effects of Aβ42 oligomers.

Amyloid - β 42 (Aβ42) has a strong ability to oligomerize to form diffusible oligomers as well as larger polymers called fibrils that form insoluble amyloid plaques, a major hallmark of AD.

Representative high - magnification confocal micrographs depicting lack of complete co-localization between pab27576 (APP / CTF - specific sites, red) and Nu1 (Aβ oligomer - specific sites, green).

Small poisonous Aβ assemblies, called oligomers, bind strongly to vulnerable neurons in the brain, but in the presence of collagen VI, this binding was blocked.

Mairet - Coello G., Courchet J., Pierault S., Courchet, V., Maximov A., Polleux F. (2013) The CAMKK2 - AMPK kinase pathway mediates the synaptotoxic effects of Aβ oligomers in vivo through Tau phosphorylation.

Importantly, we found that the inhibition of the catalytic activity of CAMKK2 or AMPK protects hippocampal neurons against the synaptotoxic effects induced by acute exposure to Aβ42 oligomers in vitro and against the loss of dendritic spines observed in the hAPPSWE,IND - expressing transgenic mouse model (J20) in vivo.

Under still unknown circumstances, Tau protein forms soluble oligomers and insoluble aggregates that are closely linked to the cause and progression of various brain pathologies, including Alzheimer's disease.

By predicting and designing these higher - order oligomers, Baker and his team have gained an understanding of the fundamental principles underlying oligomer - oligomer interactions.

Beyond the internal interactions of the protein itself, these designed oligomers can be used to explore basic questions about how the structure of signaling molecules affects the behavior of receptors and cellular response.

«The formation pathways of β - oligomers and subsequent nonfibrillar aggregates of recombinant human prion proteins.»

Why Alzheimer's is a disease of memory: the attack on synapses by A beta oligomers (ADDLs).

Last but not least, EP1LOGUE features a proprietary vasodilating and nitric oxide - boosting formulation of gallate - enhanced oligomers derived from grape seeds and marketed as 10x more powerful than the classic citrulline.

Low levels of BPA and PS oligomer have been proven to cause hormone disruption in animals.

This devastating form of dementia is characterized by the accumulation of beta - protein clusters in the brain known as oligomers.