It was led by Dr. Tim Whelan, professor
of oncology with McMaster University's Michael G. DeGroote School of Medicine and a radiation oncologist at Hamilton Health Sciences Juravinski Cancer Centre.
Not exact matches
Jim Cramer sits down
with the executive chairman
of oncology giant Novocure to get the latest on its cutting - edge tumor therapy.
BIG DATA AND CANCER: STANDARDIZATION
With Mary Beckerle
of the University
of Utah; Clifford A. Hudis
of the American Society
of Clinical
Oncology; Greg Simon
of The White House; and Clifton Leaf
of Fortune — Report by Erika Fry — Video: The Crucial Data That Will Help You Fight Cancer — Video
of the entire session
Announced a worldwide collaboration
with Sangamo Therapeutics, Inc. (Sangamo) using Sangamo's zinc finger nuclease technology platform for the development
of next - generation ex vivo cell therapies in
oncology.
These risks and uncertainties include: Gilead's ability to achieve its anticipated full year 2018 financial results; Gilead's ability to sustain growth in revenues for its antiviral and other programs; the risk that private and public payers may be reluctant to provide, or continue to provide, coverage or reimbursement for new products, including Vosevi, Yescarta, Epclusa, Harvoni, Genvoya, Odefsey, Descovy, Biktarvy and Vemlidy ®; austerity measures in European countries that may increase the amount
of discount required on Gilead's products; an increase in discounts, chargebacks and rebates due to ongoing contracts and future negotiations
with commercial and government payers; a larger than anticipated shift in payer mix to more highly discounted payer segments and geographic regions and decreases in treatment duration; availability
of funding for state AIDS Drug Assistance Programs (ADAPs); continued fluctuations in ADAP purchases driven by federal and state grant cycles which may not mirror patient demand and may cause fluctuations in Gilead's earnings; market share and price erosion caused by the introduction
of generic versions
of Viread and Truvada, an uncertain global macroeconomic environment; and potential amendments to the Affordable Care Act or other government action that could have the effect
of lowering prices or reducing the number
of insured patients; the possibility
of unfavorable results from clinical trials involving investigational compounds; Gilead's ability to initiate clinical trials in its currently anticipated timeframes; the levels
of inventory held by wholesalers and retailers which may cause fluctuations in Gilead's earnings; Kite's ability to develop and commercialize cell therapies utilizing the zinc finger nuclease technology platform and realize the benefits
of the Sangamo partnership; Gilead's ability to submit new drug applications for new product candidates in the timelines currently anticipated; Gilead's ability to receive regulatory approvals in a timely manner or at all, for new and current products, including Biktarvy; Gilead's ability to successfully commercialize its products, including Biktarvy; the risk that physicians and patients may not see advantages
of these products over other therapies and may therefore be reluctant to prescribe the products; Gilead's ability to successfully develop its hematology /
oncology and inflammation / respiratory programs; safety and efficacy data from clinical studies may not warrant further development
of Gilead's product candidates, including GS - 9620 and Yescarta in combination
with Pfizer's utomilumab; Gilead's ability to pay dividends or complete its share repurchase program due to changes in its stock price, corporate or other market conditions; fluctuations in the foreign exchange rate
of the U.S. dollar that may cause an unfavorable foreign currency exchange impact on Gilead's future revenues and pre-tax earnings; and other risks identified from time to time in Gilead's reports filed
with the U.S. Securities and Exchange Commission (the SEC).
Sierra
Oncology, Inc., a clinical stage drug development company focused on advancing next - generation DNA damage response therapeutics for the treatment
of patients
with cancer, went public near $ 29 in July 2015, then began a downtrend that continued through a June 2017 all - time low
of $ 1.10.
Julia has also mapped competitive landscapes
with a focus on immuno -
oncology and melanoma as a member of the Oncology Team within the TechAtlas division of RA
oncology and melanoma as a member
of the
Oncology Team within the TechAtlas division of RA
Oncology Team within the TechAtlas division
of RA Capital.
The Harvard Business School Kraft Precision Medicine Accelerator is working
with the MMRF and other cancer partners to harness the potential
of master protocols in precision
oncology.
«We are pleased to share this vision
with the unique blend
of crossover funds, pharmaceutical companies, and venture capital investors participating in our Series B, and look forward to advancing our position as the leading biotech
with a dual focus on synthetic lethality and immuno -
oncology.»
Triphase in - licenses clinically enabled
oncology assets
with high - value potential and develops them in a shared risk model to proof -
of - concept, then out - licenses or sells the product to create value.
With major clinical successes in areas such as CAR - T, gene therapy, immune -
oncology, cell therapy and gene editing, many see 2017 as the year that biotech really came
of age.
Drug developer Loxo
Oncology said on Tuesday it is partnering
with genetic testing company Illumina Inc on a diagnostic tool that will work
with Loxo's larotrectinib and another one
of its experimental cancer drugs, across tumor types.
April 10 Drug developer Loxo
Oncology said on Tuesday it is partnering
with genetic testing company Illumina Inc on a diagnostic tool that will work
with Loxo's larotrectinib and another one
of its experimental cancer drugs, across tumor types.
The divestment
of the cancer business may be a deterrent for Takeda, since
oncology was one
of the areas it had highlighted as driving the case for a Shire deal, along
with gastrointestinal medicine and neuroscience.
Combine this
with dozens
of oncology and ant - inflammatory collaborations for potentially first - in - class therapies, and you have a recipe for double - digit annual sales growth for years to come.
On Monday morning, as he did every two weeks, he would walk into the basement
of the
oncology center at Duke and sit
with a hundred people who stared into the nothingness, waiting hours for their turns.
Women dealing
with serious health issues, such as cancer, will have the added benefit
of having someone from an
oncology, breast center unit as part
of the birthing team
of doctors.
Outside
of this group, I am building the Little Lives Lending Library, a project to serve children and families that are admitted to our two local children's hospitals,
with particular attention to the Infant / Toddler Continuing Care and
Oncology units.
«Particularly her knowledge
of the needs
of those children she works
with in pediatric
Oncology and the families
of those children.
As a matter
of urgency, we need to train more healthcare professional (doctors, nurses, and pharmacist) in paediatric
oncology, expand treatment access to at least three others centres (Tamale, Cape Coast and Volta regions); and equip these facilities
with good Labourites to be able to detect both solid and blood cancers.
«Our study suggests that epigenetic changes to cells treated
with cigarette smoke sensitize airway cells to genetic mutations known to cause lung cancers,» says Stephen Baylin, M.D., the Virginia and D.K. Ludwig Professor for Cancer Research and professor
of oncology at the Johns Hopkins Kimmel Cancer Center.
Professor Josep Tabernero, a member
of the scientific committee for the EORTC - NCI - AACR Symposium and head
of the medical
oncology department at Vall d'Hebron University Hospital and director of the Vall d'Hebron Institute of Oncology, Barcelona, Spain, commented: «These are encouraging results, which show that galeterone has significant clinical activity in men with castration - resistant prostate cancer that fails to respond to othe
oncology department at Vall d'Hebron University Hospital and director
of the Vall d'Hebron Institute
of Oncology, Barcelona, Spain, commented: «These are encouraging results, which show that galeterone has significant clinical activity in men with castration - resistant prostate cancer that fails to respond to othe
Oncology, Barcelona, Spain, commented: «These are encouraging results, which show that galeterone has significant clinical activity in men
with castration - resistant prostate cancer that fails to respond to other drugs.
That's how Charles Sawyers, a 2009 Lasker Award winner and chair
of human
oncology and pathogenesis at Memorial Sloan - Kettering Cancer Center in New York City, made the connection
with Bristol Myers Squibb (BMS) that led to second - generation treatments for chronic myeloid leukemia (CML).
His interest in research grew while he did his medical degree at Stanford, so he enrolled in Stanford's research - residency program, which allowed him to do 2 years
of traditional residency training
with a 3rd - year research fellowship in hematology -
oncology.
«We present an interdisciplinary approach to studying immunotherapy and immune surveillance
of tumors,» said Benjamin Greenbaum, PhD, the senior author, who is affiliated
with the departments
of Medicine, Hematology and Medical
Oncology, Pathology, and Oncological Sciences at The Tisch Cancer Institute at the Icahn School
of Medicine at Mount Sinai.
Subha Madhavan, an
oncology professor and director
of the Innovation Center for Biomedical Informatics (ICBI) at Georgetown University Medical Center in Washington, D.C., was next to praise her experience
with a PSM graduate, named Shruti Rao, who earned her degree in molecular biotechnology at George Washington University, also in the nation's capital.
«Although FDA approval is critically important for introducing a new screening test or algorithm, providers ultimately rely on guidance or guidelines to help them make the best decisions for their patients and want to understand advantages, disadvantages and unknowns associated
with a new screening approach,» said Huh, who is a senior scientist for the UAB Comprehensive Cancer Center, Director
of the UAB Division
of Gynecologic
Oncology, and is also a board member for both the American Society for Colposcopy and Cervical Pathology and the Society
of Gynecologic
Oncology.
However, the majority
of patients develop treatment - resistant tumors, and only 10 to 15 percent
of these patients survive long term, says Ie - Ming Shih, M.D., Ph.D., the Richard W. TeLinde Distinguished Professor in the department
of Gynecology and Obstetrics, who led the study
with Tian - Li Wang, Ph.D., an associate professor
of pathology and
oncology at the Johns Hopkins University School
of Medicine.
By taking a high - cost drug
with a low - fat meal — instead
of on an empty stomach, as prescribed — prostate cancer patients could decrease their daily dose, prevent digestive issues and cut costs by 75 percent, according to a new study in the March 28, 2018, issue
of the Journal
of Clinical
Oncology (JCO).
«Finding the optimal conditions to avoid interfering
with immune cells working to eradicate cancer while preventing graft rejection and GVHD is the holy grail
of bone marrow transplant,» says Leo Luznik, M.D., associate professor
of oncology at the Johns Hopkins Kimmel Cancer Center.
An old idea
of retreating lung tumors
with radiation is new again, especially
with the technological advances seen in radiation
oncology over the last decade.
«Patients diagnosed
with early - stage prostate cancer — and that's the vast majority
of patients
with this disease — face many treatment options that are thought to be similarly efficacious,» said Ronald C. Chen, MD, MPH, UNC Lineberger member and associate professor in the UNC School
of Medicine Department
of Radiation
Oncology.
For men
with intermediate risk prostate cancer, side effects at two years following radiation therapy (RT) were comparable for extremely - hypofractionated treatment, which was delivered in seven fractions across two and a half weeks, and conventional treatment
of 39 fractions across eight weeks, according to research presented at the 58th Annual Meeting
of the American Society for Radiation
Oncology (ASTRO).
The study
of 1,003 men was conducted at the NIH in Bethesda, Md., from 2007 - 2014,
with Peter A. Pinto, MD, the head
of the prostate cancer section
of the urologic
oncology branch, serving as the senior investigator.
«Estimating from various studies that looked at increasing BMI and endometrial cancer risk, a woman
with a Body Mass Index (BMI)
of 40 would have approximately eight times greater risk
of endometrial cancer than someone
with a BMI
of 25,» said first author Kristy Ward, MD, the senior gynecologic
oncology fellow in the Department
of Reproductive Medicine at UC San Diego School
of Medicine.
Due to the increasing interest in digital health care systems, she moved to Roche's
oncology department, where her activities included formulating and implementing validated assays, coupled
with digital solutions and key contributions to the Discovery Biomarker portfolio and to the development
of software tools for data mining purposes.
The Michigan
Oncology Sequencing Program (MI - ONCOSEQ) facilitates integrative sequencing analysis
of tumors from patients
with advanced cancers.
Professor Paolo Boffetta (MD), the Annals
of Oncology associate editor for epidemiology and Director
of the Institute
of Translational Epidemiology at the Icahn School
of Medicine at Mount Sinai in New York (USA), commented: «These results are extremely important in showing that reducing cancer mortality can be achieved: priority should be given to research in cancers
with unfavourable trends, such as pancreatic cancer, and in reducing cancer mortality disparities, both between countries (Central / Eastern versus Western Europe), and within countries, for example, between socioeconomic groups.
«This study forms the basis for future research in patients
with breast cancer and offers hope for targeted therapy for patients
with aggressive triple - negative inflammatory breast cancer,» said lead researcher Mateusz Opyrchal, M.D., Ph.D., Assistant Professor
of Oncology at RPCI.
The shortened regimen, described online Sept. 29 in the Journal
of Clinical
Oncology, begins
with intravenous busulfan and fludarabine, two chemotherapeutic drugs that wipe out a patient's immune system and prepare his or her body to receive donated marrow.
Roche has four biologic cancer immunotherapy molecules in clinical trials that could work in powerful combinations
with each other or
with current drugs, says William Pao, global head
of oncology discovery in Basel.
«Our preclinical data suggest that combining low doses
of these inhibitors will enhance the clinical effects
of both drugs as a potential treatment for patients
with AML,» says the senior author, Feyruz V. Rassool, PhD, associate professor
of radiation
oncology at the University
of Maryland School
of Medicine (UM SOM) and a researcher at the University
of Maryland Marlene and Stewart Greenebaum Comprehensive Cancer Center (UMGCCC).
People diagnosed
with cancer gained 3.34 million years
of life thanks to cancer clinical trials run by SWOG and supported
with public funds, according to new study results to be presented at the 53rd Annual Meeting
of the American Society
of Clinical
Oncology (ASCO), the world's largest clinical cancer research meeting.
Other UT Southwestern faculty members who contributed to this research are: Dr. Boning Gao, Assistant Professor
with the Hamon Center for Therapeutic
Oncology Research and Pharmacology; Dr. Kimmo Hatanpaa, Associate Professor
of Pathology; Dr. Kemp Kernstine, Professor
of Cardiovascular and Thoracic Surgery and holder
of the Robert Tucker Hayes Foundation Distinguished Chair in Cardiothoracic Surgery; Dr. Yang Xie, Associate Professor
of Clinical Sciences and Bioinformatics; Dr. Hong Zhu, Assistant Professor
of Clinical Sciences and
with the Simmons Cancer Center; Dr. Farjana Fattah, Assistant Professor
with the Simmons Cancer Center and Pathology; Dr. Masaya Takahashi, Associate Professor
with the Advanced Imaging Research and Radiology; Dr. Bipasha Mukherjee, Assistant Professor
of Radiation
Oncology; Dr. Sandeep Burma, Associate Professor
of Radiation
Oncology; and Dr. Jonathan Dowell, Professor
of Internal Medicine;
Using genome data from more than 50,000 cancer cases and 60,000 controls through the GAME - ON (Genetic Associations and Mechanisms in
Oncology) network, the team compared telomere lengths
with the risk
of developing breast, lung, colorectal, ovarian and prostate cancers, including subtypes.
The study was led by Dr. Alexandre Zlotta, Director
of Uro -
Oncology at Mount Sinai Hospital, and researcher
with the Lunenfeld - Tanenbaum Research Institute, part
of Sinai Health System in Toronto, Canada, and Dr. Paul Boutros, Principal Investigator, Informatics and Bio-computing, Ontario Institute for Cancer Research (OICR).
Young people
with body mass indexes (BMIs) over 30 are more likely to experience aggressive malignancies, says author Nathan A. Berger, MD, Hanna - Payne Professor
of Experimental Medicine; director
of the Center for Science, Health and Society; member
of the Case Comprehensive Cancer Center; and professor
of medicine, biochemistry,
oncology and genetics at Case Western Reserve University School
of Medicine.
«It was kind
of fun being at a medical school and known as the weird guy who worked
with dogs,» says Modiano, who is now a professor
of comparative
oncology at the University
of Minnesota College
of Veterinary Medicine and the Masonic Cancer Center, where his research focuses on immunology, cancer cell biology, cancer genetics, and applications
of gene therapy.
The study — the largest to date assessing the mental and emotional health
of patients
with cancer using a fully standardized, diagnostic face - to - face interview — is published in the October 6 issue
of the Journal
of Clinical
Oncology.
«We began
with stem cells taken from cord - blood, which have fewer acquired mutations and little, if any, epigenetic memory, which cells accumulate as time goes on,» says Zambidis, associate professor
of oncology and pediatrics at the Johns Hopkins Institute for Cell Engineering and the Kimmel Cancer Center.