Snyder is a recipient of the 1978 Albert Lasker Basic Medical Research Award for identifying the relation
of opiate receptors to naturally - ocurring enkephalins.
He pioneered the labeling of receptors by reversible ligand binding in the identification
of opiate receptors and extended this technique to all the major neurotransmitter receptors in the brain.
Uhl and crew then produced mice that had half the normal number
of opiate receptors and as a result, experienced greater discomfort when exposed to a standard mildly painful stimulus.
«I am honored that the Lasker Foundation has chosen this year to recognize the field
of opiate receptor and opiate - like peptide research,» he said.
Not exact matches
Opiates,
of course, are natural or synthetic substances that bind to
opiate receptors in the brain, and are chemically similar to alkaloid compounds derived from Papaver somniferum, or the opium poppy.
At Cornell, Bowen wrote a research proposal to examine the mechanism
of action between
opiates and their
receptors, a mechanism that was largely unknown at the time.
Uhl and his colleagues, Ichiro Sora and Zaijie Wang,
of Johns Hopkins University and the National Institute on Drug Abuse (NIDA) zeroed in on the gene encoding the mu
opiate receptor — sections
of which they first identified a decade ago.
Following chronic
opiate exposure, however,
opiate reward memory formation becomes independent
of D1R, and rather depends on a second dopamine
receptor, called D2r, and a protein called CaMKII.
These findings, together with data reported several years ago on the treats» ability to turn on
opiate receptors in the brain (SN: 10/12/96, p. 235), threaten to transform the image
of chocolate from dietary vice to herbal medicine.
Ledent et al. «Unresponsiveness to Cannabinoids and Reduced Addicitive Effects
of Opiates in CB1
Receptor Knockout Mice», Science, 283 (5400): 401 - 404, 1999.
Opiate receptor research has paid off both in fundamental understanding
of brain function and in the development
of novel therapeutic agents.
Independent
of the brain effects already discussed, gliadin peptides may travel through the blood stream and can stimulate
opiate receptors in the brain, resulting in their being termed gliadorphins, accounting for temporary withdrawal symptoms!
Dr. Candace Pert has confirmed as much through her discovery
of the bodily
opiate receptor and research on neuropeptides demonstrating that that emotions are literally encoded throughout organs and tissues.
Independent
of the brain effects already discussed, gliadin peptides may travel through the blood stream can stimulate
opiate receptors in the brain resulting in their being termed gliadorphins.
This medication blocks a particular type
of opioid
receptor and has been used for many years as treatment for a narcotic overdose and to reduce the incidence
of relapse in alcoholism and
opiate addiction.
...
Opiate receptor site, and then, there's some compounds that are produced to help modulate the Immune System help that, the T - regulatory cells, to kind
of balance out that...
His theory goes that the wheat we eat today was hybridized 50 years ago, and now contains gliadin, one
of two proteins that make up gluten and which binds to
opiate receptors in our brains and stimulates our appetite.
Opiates / opioids bind to
receptors all over the body, they are especially concentrated in areas
of the brain that control breathing, pain and emotions.
It turns out that the partial blockage
of the opioid
receptors tricks the brain into producing more
of its own
opiates, thus reducing pain and improving sleep (but not generally reducing fatigue).